Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets흰 족제비에서 SARS-COV-2 감염 동안 성별 및 연령 편향 바이러스 부담 및 인터페론 반응Article Published on 2021-07-152022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] accompanied acute respiratory syndrome coronavirus Affect age Analysis antiviral responses coronavirus coronavirus 2 COVID-19 death difference expression female ferret Gene expression analysis Hospitalization immunology in viral indicated infected with SARS-CoV-2 Infection interferon response investigated male Male sex males nasal turbinate nasal turbinates Older post infection respiratory respiratory syndrome coronavirus 2 SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increases in temperature regulation Transmission upper respiratory tract Viral viral burden Viral host response Viral immune evasion viral infection viral pathogenesis viral replication Viral transmission Virology Virus-host interactions [DOI] 10.1038/s41598-021-93855-9 PMC 바로가기 [Article Type] Article
Neutrophilia, lymphopenia and myeloid dysfunction: A living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathologyReview Article Published on 2021-07-152022-10-29 Journal: Oxford Open Immunology [Category] COVID-19, [키워드] adaptive Adaptive immune response alteration association B cells basophils cell counts change changes clinical clinical decision coronavirus coronavirus disease COVID-19 COVID-19 pathology described Destabilisation disease enhances eosinophil expression Frequency HLA-DR ICU admission Immune cell implication increased risk Inflammation knowledge Lymphocytes lymphopenia monocyte Monocytes neutrophil neutrophilia Neutrophils occur outcomes parameter Patient care phenotype predict Prognosis Quantitative recovery respiratory SARS-CoV-2 SARS-COV-2 infection severe disease severity survival T cell lymphopenia tissue damage trajectory Viral immune evasion viral infections virus [DOI] 10.1093/oxfimm/iqab016 PMC 바로가기 [Article Type] Review Article
Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 생물의학적 개입으로 인한 급격한 진화 탈출의 위험Research Article Published on 2021-04-282022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 affinity Analysis antibody antibody-based prophylactics comparable COVID-19 Critical Decay kinetics deleterious mutation develop domain epitope Epitopes escape mutant escape mutants expected focus Frequency Genetic variation Immune escape immune evasion Immunity immunization in vitro infect cell Intervention molecular molecular target Mutation NAb NAbs natural antigens natural immunity Neutral Neutralizing antibodies neutralizing antibody new strain overlap passive immunization Positive selection potential mechanism predict question raise raised raising RBD RBD-targeting nAbs SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 spike protein sequence Spike protein Strategy structure-function surveillance data the RBD therapeutic timeline Transmissibility vaccinal Vaccine Vaccines Viral Viral immune evasion virus virus escape neutralizing antibodies widespread wild type [DOI] 10.1371/journal.pone.0250780 PMC 바로가기 [Article Type] Research Article
Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccinationReview Published on 2021-04-012023-06-15 Journal: Nature reviews. Immunology [Category] MERS, SARS, [키워드] Evolution Vaccines Viral immune evasion Viral transmission [DOI] 10.1038/s41577-021-00544-9 PMC 바로가기 [Article Type] Review
Vulnerabilities in coronavirus glycan shields despite extensive glycosylationArticle Published on 2020-05-272022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Clusters complex coronavirus CoVs epitope Epitopes Fatality rate fusion protein glycan glycobiology glycoprotein Glycoproteins glycosylated glycosylation high-density HIV-1 HKU1 humoral immune response immune evasion immunogenic immunological influenza hemagglutinin MERS Middle East N-linked glycosylation Neutralizing pandemic Protein Proteins S protein shielding spike syndrome trimeric spike Viral immune evasion Viral protein viral spike virus glycoprotein vulnerability zoonotic pathogen [DOI] 10.1038/s41467-020-16567-0 PMC 바로가기 [Article Type] Article
COVID-19: Unanswered questions on immune response and pathogenesisArticle Published on 2020-05-082023-06-15 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, [키워드] ACE2, angiotensin-converting enzyme 2 Anti–SARS-CoV-2 immunity COVID-19 pathogenesis COVID-19, Coronavirus disease 2019 IC, Intensive care IFN-1, Type I interferon nAb, Neutralizing Antibody NK, natural killer RBD, receptor-binding domain rCoV, Respiratory coronavirus SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Viral immune evasion [DOI] 10.1016/j.jaci.2020.05.001 PMC 바로가기
Antigenic characterization of novel H1 influenza A viruses in swineArticle Published on 2020-03-112023-06-08 Journal: Scientific Reports [Category] 신종인플루엔자, [키워드] Influenza virus Viral immune evasion [DOI] 10.1038/s41598-020-61315-5 PMC 바로가기 [Article Type] Article
Circulating and Hepatic BDCA1+, BDCA2+, and BDCA3+ Dendritic Cells Are Differentially Subverted in Patients With Chronic HBV InfectionOriginal Research Published on 2019-02-042023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] antiviral immune responses cDC1/BDCA3 cDC2/BDCA1 chronic hepatitis B patients Hepatitis B virus pDCs/BDCA2 type I and type III interferons Viral immune evasion [DOI] 10.3389/fimmu.2019.00112 PMC 바로가기 [Article Type] Original Research
Immunological evasion of immediate-early varicella zoster virus proteinsArticle Published on 2016-07-012023-05-31 Journal: Immunogenetics [Category] 두창, 수두, 홍역, [키워드] HLA association MHC affinity prediction Varicella zoster virus Viral immune evasion [DOI] 10.1007/s00251-016-0911-4
Immunological evasion of immediate-early varicella zoster virus proteinsArticle Published on 2016-07-012023-05-31 Journal: Immunogenetics [Category] 두창, 수두, 홍역, [키워드] HLA association MHC affinity prediction Varicella zoster virus Viral immune evasion [DOI] 10.1007/s00251-016-0911-4