Long-Term SARS-CoV-2 Specific Immunity Is Affected by the Severity of Initial COVID-19 and Patient AgeArticle Published on 2021-10-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome affecting age caused Cohort convalescent coronavirus coronavirus disease COVID-19 COVID-19 severity demonstrated effective Factor humoral immune response Humoral immunity immune response Immunity immunosuppressed patient initial management membrane protein memory response pandemic Patient patients persistence Protein SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity severity Specific spike Spike protein T cell T cell responses virus virus-neutralizing antibodies was determined [DOI] 10.3390/jcm10194606 PMC 바로가기 [Article Type] Article
Current scenario of COVID-19 vaccinations and immune response along with antibody titer in vaccinated inhabitants of different countries다른 국가의 예방 접종을받은 주민의 항체 역가와 함께 COVID-19 예방 접종 및 면역 반응의 현재 시나리오Review Published on 2021-10-012022-09-11 Journal: International immunopharmacology [Category] SARS, 변종, [키워드] Adaptive immunity addition addressed Antibody titer approach cellular Cellular and humoral responses cellular immunity Clinical management clinical trial Combination country COVID-19 COVID-19 pandemic COVID-19 vaccination Critical current generate Humoral response immune immune response immune responses Immunity inactivated induce Infection long-lasting neutralization Neutralizing antibodies nucleic acid overcome pathogenicity peptide phase 4 Population proportion response rising Safe Safety assessment SARS-CoV-2 SARS-CoV-2 variants Spread Trial vaccination Vaccine vaccine candidates Vaccine development Vaccine-induced immunity Vaccines variant variants variants of SARS-CoV-2 virus virus-neutralizing antibodies virus-neutralizing antibody [DOI] 10.1016/j.intimp.2021.108050 PMC 바로가기 [Article Type] Review
Persistence of Antibody and Cellular Immune Responses in Coronavirus Disease 2019 Patients Over Nine Months After Infection감염 후 9개월 동안 코로나바이러스 질병 2019 환자의 항체 및 세포 면역 반응의 지속성Article Published on 2021-08-162022-09-11 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed antibody Asymptomatic B cell response Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-sectional cross-sectional study detectable domain enrolled Enrollment humoral IgG antibodies IgG antibody immune memory Immunoglobulin Infection interferon interquartile range median median age memory B memory B cell memory T memory T cell men Mild moderate Month Most patients Neutralizing Neutralizing antibodies neutralizing antibody nucleocapsid protein Nucleocapsid proteins nucleoprotein nucleoprotein of SARS-CoV-2 over Patient patients patients with COVID-19 performed persist persistence provide pseudovirus Receptor-binding domain Reinfection respiratory response SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus spike and nucleocapsid proteins symptom onset T cell T cell response the receptor-binding domain Vaccination strategy virus-neutralizing antibodies were measured women [DOI] 10.1093/infdis/jiab255 PMC 바로가기 [Article Type] Article
Peripheral Plasma Cells Associated with Mortality Benefit in Severe COVID-19: A Marker of Disease Resolution심각한 COVID-19에서 사망률과 관련된 말초 형질 세포: 질병 해결의 지표Article Published on 2021-08-012022-09-11 Journal: The American journal of medicine [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval adjusted adjusted hazard ratio age analytics association body mass body mass index Clinical improvement convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 Course covariate COVID-19 Cox regression model Cox regression models Cytokines death detectable differentiation disease severity evaluate flow cytometric fluorescent hazard ratio Health Organization Hospitalized hospitalized patient identify immune response improved mortality Infection Johns Hopkin Johns Hopkins lymphocyte Lymphocytes Medicine Mortality Neutralizing antibodies p value Patient peripheral Peripheral blood Plasma cell Plasma cells plasmacytosis plasmacytosis. proliferation reduced registry Resolution respiratory Respiratory Coronavirus SARS-CoV-2 screening method severe acute respiratory coronavirus severe acute respiratory coronavirus 2 severe coronavirus disease severe disease Sex stratified survival virus-neutralizing antibodies virus-neutralizing antibody were used WHO World Health Organization [DOI] 10.1016/j.amjmed.2021.01.040 PMC 바로가기 [Article Type] Article
Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster ModelCOVID-19 골든 시리아 햄스터 모델에서 폐 영상 및 SARS-CoV-2 항체 반응의 성별 차이Research Article Published on 2021-07-132022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Alter animal animal model animal models body mass cause caused causes Chest computed tomography comparable Computed tomography concentrations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture cytokine deaths difference dose estradiol euthanized female females greater hamster Hospitalization hospitalizations human population IFN-β IgA response IgA responses IgG IgG antibodies IgG antibody IgM imaging Infection Infectious virus infective Infective dose inoculated interferon intranasally Lungs male Model morbidity Mortality mounted mutant nasal turbinates outcome pandemic Pathogenesis pathogenesis of SARS-CoV-2 plasma Pneumonia pulmonary damage RBDs Receptor-binding domain reported respiratory respiratory tissues response S-RBD SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Sex difference sex differences significantly Spike protein TCID the receptor-binding domain the spike protein tissue tissue culture TNF-α Trachea Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α virus virus titers virus-neutralizing antibodies virus-neutralizing antibody [DOI] 10.1128/mBio.00974-21 PMC 바로가기 [Article Type] Research Article
Development of SARS-CoV-2 Specific IgG and Virus-Neutralizing Antibodies after Infection with Variants of Concern or VaccinationArticle Published on 2021-06-252022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anti-N IgG Anti-RBD IgG anti-S IgG AstraZeneca avidity B.1.1.7 B.1.351 BNT162b2 ChAdOx1 concern contribute convalescent COVID-19 cVNT demonstrated detectable development domain Evidence examined humoral immune response Humoral immunity IgG immune response immunoblot Immunoglobulin increase in Infection Maturity Moderna mRNA-1273 neutralization Pfizer/BioNTech RBD reactivity robust SARS-CoV-2 SARS-COV-2 infection second dose sera Specific starting sVNT tested titer vaccination vaccine dose vaccinee vaccinees variants of concern viral spike virus variants virus-neutralizing antibodies virus-neutralizing antibody VoC was determined were used [DOI] 10.3390/vaccines9070700 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster ModelSARS-CoV-2 중화 인간 항체는 햄스터 모델에서 하부 호흡기 질환으로부터 보호합니다Article Published on 2021-06-152022-09-12 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 진단, [키워드] administration Against Antiviral treatment clinical trial complementary convalescent convalescent plasma coronavirus disease COVID-19 Donor Effectiveness evaluated hamster highlight Human Intervention Lower Lungs Model monoclonal monoclonal antibody Neutralizing antibodies neutralizing antibody plasma Pneumonia Prevent Prophylactic prophylactically protective effect reduced reduction respiratory SARS-CoV-2 severe SARS-CoV-2 tract treated virus replication virus-neutralizing antibodies weight loss [DOI] 10.1093/infdis/jiab289 PMC 바로가기 [Article Type] Article
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged miceClinical and Translational Article Published on 2021-03-122022-11-01 Journal: Med (New York, N.Y.) [Category] COVID-19, MERS, SARS, [키워드] Abstract Adaptive immune response administration Adults affected aging antibodies Antibody Response approach booster dose caused CD4 CD8 CD8+ T cells Cell cellular ChAdOx1 ChAdOx1 nCoV-19 changes in Clinical outcome Context COVID-19 COVID-19 vaccine COVID-19 vaccines effective effectors elicit ENhance finding follicular funding generate Germinal center Health Humoral immunity IgG and IgM immune response immune system immunogenicity induce Infection influence intramuscular limit magnitude Measures Medicine mice morbidity and mortality Older outcome performed plasma pre-clinical testing protective immunity reduced Regulatory required risk factor robust SARS-CoV-2 SARS-COV-2 infection second dose single dose single vaccination Spread stimulate supported T follicular helper cells Th1 cells vaccination Vaccine vaccine candidate virus-neutralizing antibodies worldwide pandemic [DOI] 10.1016/j.medj.2020.12.006 PMC 바로가기 [Article Type] Clinical and Translational Article
Serum-IgG responses to SARS-CoV-2 after mild and severe COVID-19 infection and analysis of IgG non-responders경증 및 중증 COVID-19 감염 후 SARS-CoV-2에 대한 혈청-IgG 반응 및 IgG 무반응자 분석Research Article Published on 2020-10-212022-08-13 Journal: PLoS ONE [Category] COVID-19, Medicine and Health Sciences, MERS, SARS, [키워드] Abbott Abbott Laboratories Abbott Laboratory age Analysis antibody Antibody titers Architect clinically Cohort cohort of patient Concentration COVID-19 COVID-19 patient detectable develop female Follow-up house iFlash IgG IgG antibodies IgG antibody IgG level IgG responses Immunity imperative Interpretation knowledge median Mild Mild symptom mild symptoms Neutralizing antibodies non-responder Nucleocapsid proteins Patient preserved quantified Receptor binding remained response Result SARS-CoV-2 SARS-CoV-2-specific IgG Seroconversion seroconvert seroconverted Serological assay seronegative serum severe COVID-19 Severe COVID-19 Infection severe symptom severe symptoms severity of symptoms significantly shorter specific IgG antibodies spike and nucleocapsid proteins spike-protein symptom onset time virus-neutralizing antibodies virus-neutralizing antibody [DOI] 10.1371/journal.pone.0241104 PMC 바로가기 [Article Type] Research Article
A Novel In-Cell ELISA Assay Allows Rapid and Automated Quantification of SARS-CoV-2 to Analyze Neutralizing Antibodies and Antiviral Compounds새로운 세포 내 ELISA 분석을 통해 SARS-CoV-2의 신속하고 자동화된 정량화를 통해 중화 항체 및 항바이러스 화합물 분석Immunology Published on 2020-10-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibodies Antigen antiviral agent Antiviral agents antiviral drug antiviral drugs antiviral interferon antiviral interferons Applying approach automated caused Cell culture cell lines Compound convalescent plasma convalescent sera coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnostics dose doses Duration of infection Efficacy ELISA ELISAs equipment evaluate human sera Immunity immunity certificates infected cells interferon interferons NAb NAbs neutralization Neutralization assay neutralization test neutralization tests Neutralizing novel optimization other coronaviruses parameter plaque reduction neutralization PRNT quantification Quantitative raised Rapid reagent reagents reduced respiratory SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 PRNT SARS-CoV-2-infected cell SARS-CoV-2-infected cells serological severe acute respiratory syndrome Coronavirus the SARS-CoV-2 time-consuming Vaccine vaccine candidate virus virus infection virus-neutralizing antibodies virus-neutralizing antibody virus-specific antibodies viruses [DOI] 10.3389/fimmu.2020.573526 PMC 바로가기 [Article Type] Immunology