Possible Roles of Permafrost Melting, Atmospheric Transport, and Solar Irradiance in the Development of Major Coronavirus and Influenza PandemicsArticle Published on 2021-03-162022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Affect airborne transport amplification Arctic atmospheric available data Characteristics circulation climate and disease Combination concentrations COVID-19 COVID-19 case develop development distribution environment and health explain historic influenzas Human Immune suppression Immunosuppression increases in indicate infections irradiance Jet stream Laboratory Major melting Microbiome North Novel viruses occur pandemic emergence Pandemics Permafrost permafrost melting polar Pollution producing respiratory virus role sequence Solar Spread spring supported survival tested thawing Transport ultraviolet ultraviolet immunosuppression variations virus Wuhan [DOI] 10.3390/ijerph18063055 PMC 바로가기 [Article Type] Article
Th1 skewed immune response of whole virion inactivated SARS CoV 2 vaccine and its safety evaluationArticle Published on 2021-03-102022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract adjuvants agonist aluminum animal model Antibody Response Antigen BSL-3 facility carried CD4 clinical trial Concentration concentrations elevated gel humans hydroxide IFN-γ immune response Immunity immunogenicity immunology inactivated Inactivated vaccine mice Microbiology NAb titer Neutralizing antibody titer platform product profiles purified response robust Safe SARS CoV SARS-CoV-2 strain SARS-CoV-2 vaccine significantly skewed Support T lymphocyte response Th1 TLR7/8 Vaccine Vero Cell virion Virology [DOI] 10.1016/j.isci.2021.102298 PMC 바로가기 [Article Type] Article
PM2.5 emissions, concentrations and air quality index during the COVID-19 lockdownArticle Published on 2021-03-012023-07-11 Journal: Environmental pollution (Barking, Essex : 1987) [Category] SARS, [키워드] air quality index concentrations COVID-19 Emissions lockdown PM2.5 [DOI] 10.1016/j.envpol.2020.115973 PMC 바로가기
Biomarkers and short-term prognosis in COVID-19COVID-19의 바이오마커 및 단기 예후Observational Study Published on 2021-03-012022-08-31 Journal: Biomarkers : biochemical indicators of exposure, r [Category] MERS, 바이오마커, 임상, [키워드] 95% CI Admission best Biomarker Biomarkers C-reactive protein C-reactive protein (CRP cardiac troponin Cardiac troponin I Concentration concentrations COVID-19 CRP cut-off cut-off point D-dimer death dimer emergency department evaluated hazard ratio increased risk Lactate lactate dehydrogenase LDH Mortality mortality risk multivariate adjustment Patient patients with COVID-19 Prognosis Prognostic value provide short-term prognosis significantly troponin troponin I two group two groups with COVID-19 [DOI] 10.1080/1354750X.2021.1874052 PMC 바로가기 [Article Type] Observational Study
Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank인슐린 유사 성장 인자-1의 사전 진단 순환 농도 및 COVID-19 사망 위험: UK Biobank의 결과Article Published on 2021-03-012022-09-11 Journal: European Journal of Epidemiology [Category] SARS, 바이오마커, [키워드] 95% CI 95% confidence interval association baseline circulating CIs Concentration concentrations coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infection correlation coefficient COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 prognosis death deteriorate determine deviation Endocrine growth factor highest IGF-1 immune system implicated IMPROVE Inflammatory Injury insulin insulin-like growth factor insulin-like growth factor-1 investigated log-transformed Logistic regression lower risk lowest Mortality mortality risk occurred Odds ratio pathway Prognosis quartile reduction in required resource risk risk of COVID-19 SARS-CoV-2 Sensitivity analyses serum stratified UK biobank was performed [DOI] 10.1007/s10654-020-00709-1 PMC 바로가기 [Article Type] Article
Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-19Observational Study Published on 2021-03-012022-10-05 Journal: In vivo (Athens, Greece) [Category] SARS, 임상, [키워드] Appropriate case control study circulating concentrations conditions Control control group COVID-19 COVID-19 patient COVID-19 patients Critical critically-ill cytokine cytokine level Cytokine storm Dexamethasone disease severity elevated Essential Evaluating group ICU ICU admission IL-10 IL-6 IL-8 illness Illness severity intensive care interleukin mechanically ventilated Non-COVID-19 Non-COVID-19 patients Patient patients recognize reported Selection Sepsis Septic shock storm the cytokine storm TNF-α tumour necrosis factor-α were measured [DOI] 10.21873/invivo.12381 PMC 바로가기 [Article Type] Observational Study
Population pharmacokinetics of lopinavir/ritonavir in Covid-19 patients코로나19 환자에서 로피나비르/리토나비르의 집단 약동학Article Published on 2021-03-012022-09-11 Journal: European Journal of Clinical Pharmacology [Category] 치료제, [키워드] 50% effective concentration age Alanine alanine aminotransferase ALT Analysis aspartate Aspartate aminotransferase AST BMI body mass body mass index body weight C reactive protein Concentration concentrations coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 creatinine CRP data set described develop dose effective estimate females Final Gender Height high variability hospitalized patient interval Lopinavir Lopinavir/ritonavir males median mixed-effects modeling parameter Patient patients pharmacokinetic pharmacokinetics PK parameters plasma concentration Population proportion reduce regimen Ritonavir SARS-CoV-2 virus significant effect Steady state tested Vero E6 Vero E6 cell VERO E6 cells was tested [DOI] 10.1007/s00228-020-03020-w PMC 바로가기 [Article Type] Article
Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteasesResearch Published on 2021-02-282022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] 3CL pro addition Anacardic acid antivirals characterized Compound compounds concentrations cysteine protease demonstrated develop enzyme ginkgolic acid in vitro inhibit SARS-CoV-2 inhibitor inhibitors of SARS-CoV-2 mechanism of action natural product nontoxic Papain-like protease Papain‐like protease protease provide Replication Result SARS-CoV-2 the SARS-CoV-2 [DOI] 10.1186/s13578-021-00564-x PMC 바로가기 [Article Type] Research
A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CL pro Inhibitor PF-00835231 as a Potential New Treatment for COVID-19Vaccines and Antiviral Agents Published on 2021-02-232022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] 3CL pro A549 ACE2 acute respiratory syndrome airway airway epithelium alveolar Analysis Antiviral Antiviral compound antiviral drug approach approved Cell cells clades clinical trials Comparative complex component concentrations coronavirus coronavirus disease COVID-19 cultures develop direct-acting drug candidate effective Efficacy epithelial epithelial cell etiological agent Evidence experiment Express GC-376 Human airway epithelium human airway epithelium cultures in vitro in vitro model inhibit SARS-CoV-2 inhibitor kidney M pro New P-glycoprotein polymerase polyprotein Potential protease provide regimen Remdesivir SARS-CoV-2 SARS-CoV-2 life cycle SARS-CoV-2 protease Side effect suggested targets the SARS-CoV-2 the timing time-of-addition experiments treat VERO E6 cells viral life cycle [DOI] 10.1128/JVI.01819-20 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Optical Detection of CoV-SARS-2 Viral Proteins to Sub-Picomolar ConcentrationsArticle Published on 2021-02-232022-10-27 Journal: ACS Omega [Category] COVID-19, [키워드] Antigen antigen detection approach binding bovine concentrations Control experiment controls coronavirus detect detection Detection limit Diagnosis effective equipment global pandemic Laboratory new strain optical performed Protein Raman spectroscopy reagent reduce robust SARS-CoV-2 SARS-CoV-2 spike protein selective serum albumin Spike protein surface plasmon resonance viral infections [DOI] 10.1021/acsomega.1c00008 PMC 바로가기 [Article Type] Article