Has the COVID-19 Crisis Affected the Growth of United States Food and Drug Administration Drug Approvals? The Answer is Not Yet! A Time Series (Forecasting) StudyCOVID-19 위기가 미국 식품의약국 의약품 승인 증가에 영향을 미쳤습니까? 답은 아직 아니다! 시계열(예측) 연구Article Published on 2021-05-012022-08-31 Journal: Therapeutic innovation & regulatory science [Category] MERS, 신약개발, [키워드] activities acute respiratory syndrome acute respiratory syndrome coronavirus affected approach approval auto average complex coronavirus COVID-19 crisis drug Drug development ERAS extreme FDA food Forecasting HCoV HCoV-19 initial momentum moving average performed Policy provided Replication respiratory Sery severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structure Support time United State United States [DOI] 10.1007/s43441-020-00249-6 PMC 바로가기 [Article Type] Article
Exploring insights of hydroxychloroquine, a controversial drug in Covid-19: An updateCovid-19에서 논란의 여지가 있는 약물인 하이드록시클로로퀸에 대한 통찰력 탐색: 업데이트Review Published on 2021-05-012022-09-11 Journal: Food and chemical toxicology : an international jo [Category] 신약개발, 치료제, [키워드] analysed article Asymptomatic Chloroquine clinical clinical trial conducted COVID-19 COVID-19 patients Efficacy extreme HCQ health worker higher risk Hydroxychloroquine include management mechanism Mild mild symptoms Neutral pandemic parameter Patient Pharmacodynamics pharmacokinetic pharmacokinetics Prophylactic regimen reported Research SARS-CoV-2 SARS-CoV-2 pandemic stages Symptoms the SARS-CoV-2 Toxicity Treatment Trial utility [DOI] 10.1016/j.fct.2021.112106 PMC 바로가기 [Article Type] Review
A call to caution when hydroxychloroquine is given to elderly patients with COVID-19Randomized Controlled Trial Published on 2021-05-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 신약개발, 임상, [키워드] addition Administered administration of hydroxychloroquine Adverse adverse effects age caused clinical trial clinical trials co-medication co-morbidity contraindications contributing to coronavirus disease COVID-19 detrimental diabete disease double-blind drug Elderly patient eligible enrolment extreme for inclusion health condition heart failure hospitalized patient Hydroxychloroquine Interaction interquartile range involved majority Patient patients with COVID-19 placebo-controlled Randomized renal retrospective risk Safe SARS-CoV-2 severe COVID-19 Treatment treatment effects Trial use of hydroxychloroquine widespread with COVID-19 [DOI] 10.1016/j.ijid.2021.04.009 PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19: Black Swan or clumsy use?COVID-19: 블랙 스완 또는 서투른 사용?Article Published on 2021-04-292022-09-12 Journal: Journal of preventive medicine and hygiene [Category] MERS, SARS, 진단, [키워드] affected arising black catastrophic caused characterized conditions COVID-19 COVID-19 pandemic diagnostics epidemiological purpose evaluated exceptional value extreme Health healthy IgM/IgG Italy Laboratory Laboratory test limitation measure Prevalence protocol readmission RT-PCR SARS-CoV-2 serological test serologically positive Swan the epidemic [DOI] 10.15167/2421-4248/jpmh2021.62.1.1829 PMC 바로가기 [Article Type] Article
Clinical features and outcomes of COVID-19 patients hospitalized for psychiatric disorders: a French multi-centered prospective observational studyOriginal Article Published on 2021-04-272022-10-29 Journal: Psychological Medicine [Category] COVID-19, MERS, [키워드] 350 patient affective age analyzed Care clinical clinical feature Comorbidity conducted confidence interval confusional Confusional state COVID-19 COVID-19 in patient COVID-19 patient deaths died disorder extreme feature French high risk higher risk Hospitalized increased mortality Inpatient Logistic lower risk Mental mental health Mortality outcome Patient predicted prospective observational study Prospective Study Psychiatric psychiatric disorder Psychiatric disorders psychiatry respiratory symptom Result risk risk factor risk of death severe psychiatric disorder severe respiratory symptom smoking transfer transferred Univariate analysis were assessed [DOI] 10.1017/S0033291721001537 PMC 바로가기 [Article Type] Original Article
Diagnostic accuracy of the WHO clinical definitions for dengue and implications for surveillance: A systematic review and meta-analysisResearch Article Published on 2021-04-262022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] Coronavirus, MERS, SARS, [키워드] absence access Accuracy age analysed association clinical criteria Clinical diagnosis COVID-19 COVID-19 pandemic criteria dataset Dengue Dengue fever diagnose diagnosed diagnostic Diagnostic accuracy disease disease course eligibility evaluated exacerbated extreme febrile illness implication improvement increasingly laboratory confirmation Laboratory test measure Measures Meta-analysis Modification national guideline national guidelines network analysis nonspecific pathogen produced protocol Public health response QUADAS-2 regions Registered Regression model reported researcher resource rising risk of bia searched sensitivity significantly specificity suffered Surveillance Symptom systematic review the WHO Transmission vaccination virus was done Weighting while WHO [DOI] 10.1371/journal.pntd.0009359 PMC 바로가기 [Article Type] Research Article
A hybrid data envelopment analysis—artificial neural network prediction model for COVID-19 severity in transplant recipientsArticle Published on 2021-04-232022-10-28 Journal: Artificial Intelligence Review [Category] COVID-19, [키워드] Accuracy Analysis ANN Artificial neural network Clustering Cohort competing COVID-19 COVID-19 severity Data envelopment analysis Evidence evolution of patient extreme health center health emergency health system help Hospital admission Hospitalized information kidney transplant Logistic regression management network Neural pandemic patients performed populations predicted predictor progression random Random forest recipient recipients resource severe COVID-19 disease supplementary material the SARS-CoV-2 [DOI] 10.1007/s10462-021-10008-0 PMC 바로가기 [Article Type] Article
An Early Warning Tool for Predicting Mortality Risk of COVID-19 Patients Using Machine LearningArticle Published on 2021-04-212022-10-31 Journal: Cognitive Computation [Category] COVID-19, [키워드] age AUC Biomarker Blood calculated China Clinical characteristics conducted COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 positive patient cutoff value dataset death demographic disease Early warning tool extreme global healthcare group help high mortality High-sensitivity C-reactive protein hospital identify IMPROVE investigated less lymphocyte machine learning management Mortality mortality risk neutrophil outcome Patient patients predict Predicting mortality risk predictor Probability prognostic model reduce mortality resource Retrospective study risk of COVID-19 severity Stratification the disease Tongji Hospital validation cohort [DOI] 10.1007/s12559-020-09812-7 PMC 바로가기 [Article Type] Article
The proportion and effect of corticosteroid therapy in patients with COVID-19 infection: A systematic review and meta-analysisCOVID-19 감염 환자에서 코르티코스테로이드 요법의 비율과 효과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-04-212022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis Anti-inflammatory articles China clinical trial clinical trials Comprehensive conducted Controlled coronavirus coronavirus disease Coronavirus disease 2019 Corticosteroid corticosteroid therapy corticosteroid treatment Corticosteroids COVID-19 COVID-19 patient COVID-19 patients demonstrated died effect size Efficacy evaluate extreme ICU immunosuppressive drug immunosuppressive drugs IMPROVE indicate Infection intensive care intensive care unit journal literature review mean difference Meta-analysis Mortality network no significant difference not correlated objective observational studies observational study Odds ratio outcome outcome measure outcome measures outcomes Patient patients treated patients with COVID-19 performed proportion proportions receive registry reported Research respiratory Result severe acute respiratory syndrome Coronavirus significantly significantly higher significantly lower stratified Subgroup analyses subject systematic review The effect size those who survived treated Treatment treatment of COVID-19 Trial use of corticosteroid Viral viral clearance [DOI] 10.1371/journal.pone.0249481 PMC 바로가기 [Article Type] Meta-Analysis
Research and Management of Rare Diseases in the COVID-19 Pandemic Era: Challenges and CountermeasuresPublic Health Published on 2021-04-152022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Care challenge Clinical management clinical trial Clinicians conditions coronavirus disease counseling countermeasure COVID-19 diagnostics disorders extreme genetic disease help impacted Infection management Non-COVID-19 pandemic Patient patients patients with COVID-19 rare disease rare disease community rare diseases Research researchers routine care shown Still Telemedicine therapy Transmission [DOI] 10.3389/fpubh.2021.640282 PMC 바로가기 [Article Type] Public Health