small molecule – Page 20 – Communicable Diseases Research

Small molecule therapeutics for COVID-19: repurposing of inhaled furosemide

Cell Biology

Published on 2020-07-072022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] “cytokine storm” addition Anti-inflammatory anti-inflammatory activity anti-inflammatory cytokine applicability biologic caused cell line clinical trial clinical utility coronavirus COVID-19 Cytokine storm Cytokines evaluate furosemide Health host inflammatory response hypercytokinemia identify IL-1ra IL-6 IL-8 immuno-inflammatory in silico in vitro Inhaled inhibitor of IL-6 initial Innate immunity involved lethal infection LPS mechanism of action molecular docking morbidity and mortality multiple cytokine novel coronavirus SARS-CoV-2 Pathogenesis pro-inflammatory cytokine pro-inflammatory cytokines promote Safe small molecule stimulated subsequent suppresse therapeutic therapy THP-1 TNF-α Treatment viral infection virus was reduced
[DOI] 10.7717/peerj.9533 PMC 바로가기 [Article Type] Cell Biology

Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 Infection

Pharmacology

Published on 2020-07-022022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19

Research Article

Published on 2020-07-012022-10-31
Journal: F1000Research [Category] COVID-19, MERS, SARS,

Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection

Communication

Published on 2020-06-252022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

Virtual drug repurposing study against SARS-CoV-2 TMPRSS2 target

Article

Published on 2020-06-212022-10-29
Journal: Turkish Journal of Biology [Category] COVID-19,

A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity

Original Research

Published on 2020-06-192023-06-08
Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자,

[키워드] Combination adjuvant influenza virus infection small molecule synthetic TLR4 agonist synthetic TLR7 agonists Vaccine
[DOI] 10.3389/fimmu.2020.01207 PMC 바로가기 [Article Type] Original Research

Common-path interferometric label-free protein sensing with resonant dielectric nanostructures

Article

Published on 2020-06-022022-10-04
Journal: Light, Science & Applications [Category] 바이오마커,

COVID-19: An Update about the Discovery Clinical Trial

Opinion

Published on 2020-05-142022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

[키워드] Chloroquine clinical clinical evaluation Combination Complete COVID-19 drug European finding Hydroxychloroquine Lopinavir/ritonavir pandemic plasma Remdesivir Result Safe SARS-CoV-2 small molecule Spread therapy treatments for COVID-19
[DOI] 10.3390/ph13050098 PMC 바로가기 [Article Type] Opinion

Safety of Janus Kinase Inhibitors in Patients With Inflammatory Bowel Diseases or Other Immune-mediated Diseases: A Systematic Review and Meta-Analysis

염증성 장 질환 또는 기타 면역 매개 질환 환자에서 자누스 키나제 억제제의 안전성: 체계적 검토 및 메타 분석

Meta-Analysis

Published on 2020-05-012023-06-02
Journal: Gastroenterology [Category] 대상포진, 두창, 홍역,

[키워드] IBD Immunosuppression NMSC small molecule
[DOI] 10.1053/j.gastro.2020.01.001 [Article Type] Meta-Analysis

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

Article

Published on 2020-04-302022-11-01
Journal: Virus research [Category] COVID-19, SARS,

[키워드] Abstract acute respiratory syndrome Animal coronaviruses antiviral activity antiviral agent Antiviral agents article caffeic acid Compound compounds Coronaviral Coronaviridae coronavirus coronavirus inhibitor coronavirus strains COVID-19 database disease effective fused Human IBV include infections Infectious Bronchitis Virus lack majority MERS Middle East Middle East respiratory syndrome (MERS) Mortality MOST natural Naturally Other plants plasma concentrations polar quercetin Research responsible SARS-CoV-2 searched Severe acute respiratory syndrome (SARS) small molecule syndrome therapeutic therapeutic agent Traditional medicine utility
[DOI] 10.1016/j.virusres.2020.197989 PMC 바로가기 [Article Type] Article