Computational screening of 645 antiviral peptides against the receptor-binding domain of the spike protein in SARS-CoV-2SARS-CoV-2에서 스파이크 단백질의 수용체 결합 도메인에 대한 645개 항바이러스 펩티드의 컴퓨터 스크리닝Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료제, [키워드] angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-RBD Antiviral Antiviral agents antiviral peptide binding Contact contact with Critical domain effective Efficacy enzyme exhibited feature GLU GLY guideline hACE2 hACE2 receptor higher affinity Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonding hydrophobic hydrophobic interactions in vitro in vivo inhibit inhibition inhibitor inhibitors Interaction internalization molecular dynamics Molecular dynamics simulation peptide peptides predicted Protein RBD Receptor-binding domain residue S protein SARS-CoV 2 SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike screened selected Small molecules Spike protein stable complex surface area the RBD the receptor-binding domain the S protein the spike protein Tolerability TYR virus [DOI] 10.1016/j.compbiomed.2021.104759 PMC 바로가기 [Article Type] Article
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus ProteaseArticle Published on 2021-08-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] addition Administered amino acid residue Antiviral agents binding binding domain can be used complex complexes coronavirus disease correlated Course COVID-19 COVID-19 patients demonstrated development disease docked docking docking result docking score drug candidate drug design effective exhibited flavonols Free energy calculations in silico in silico Approach inhibitor inhibitory Interaction investigated involved less Ligand M pro MPro MDs MM/GBSA molecular Molecular dynamics simulation molecular target molecule Mutation myricetin Myricitrin natural natural products protein-ligand interaction reduced Remdesivir residue RMSD RMSF rutin SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro selected Source stability Treatment Vaccine [DOI] 10.3390/ijms22179431 PMC 바로가기 [Article Type] Article
An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facilityResearch Article Published on 2021-08-262022-10-27 Journal: Bioengineered [Category] COVID-19, [키워드] Abbreviation Abstract acute respiratory syndrome Antiviral agents approach Balanced biohazard BSL BSL3 BSL3 laboratory bypassing coding conditions coronavirus COVID19 develop enzyme functional fusion fusion mimic global pandemic Human human ACE2 receptor in vitro Infection infective inhibition assay inhibitor Interaction Laboratory Level M protein mammalian cell mammalian cells mouse required resource restrict S protein Safety salt SARS-CoV2 SARS-CoV2 infection secure shown Syncytia target protein the S protein transfected with treat Vaccine virus [DOI] 10.1080/21655979.2021.1955509 PMC 바로가기 [Article Type] Research Article
An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facilityResearch Article Published on 2021-08-262022-10-27 Journal: Bioengineered [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] Abbreviation Abstract acute respiratory syndrome Antiviral agents approach Balanced biohazard BSL BSL3 BSL3 laboratory bypassing coding conditions coronavirus COVID19 develop enzyme functional fusion fusion mimic global pandemic Human human ACE2 receptor in vitro Infection infective inhibition assay inhibitor Interaction Laboratory Level M protein mammalian cell mammalian cells mouse required resource restrict S protein Safety salt SARS-CoV2 SARS-CoV2 infection secure shown Syncytia target protein the S protein transfected with treat Vaccine virus [DOI] 10.1080/21655979.2021.1955509 PMC 바로가기 [Article Type] Research Article
Natural Bioactive Molecules as Potential Agents Against SARS-CoV-2Pharmacology Published on 2021-08-172022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 3CL pro ACE2 acting Against agent Antiviral agents antiviral drug Characteristics clinically coronavirus COVID-19 death develop Helicase host proteins human cells information Invasion mechanisms MERS-CoV molecule natural natural bioactive molecules Pandemics plants Potential public health RdRP reported resource SARS-CoV SARS-CoV-2 Stage target therapeutic agents therapeutic targets Till TMPRSS2 Treatment viral infection viral life cycle [DOI] 10.3389/fphar.2021.702472 PMC 바로가기 [Article Type] Pharmacology
Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approachesReview Published on 2021-08-162023-06-15 Journal: Molecular biology reports [Category] MERS, SARS, [키워드] Antiviral agents COVID-19 genomics Therapeutic approach Vaccine [DOI] 10.1007/s11033-021-06630-4 PMC 바로가기 [Article Type] Review
Ciclesonide Inhaler Treatment for Mild-to-Moderate COVID-19: A Randomized, Open-Label, Phase 2 TrialArticle Published on 2021-08-122022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval acute respiratory syndrome adverse event Analysis antiviral agent Antiviral agents assigned Ciclesonide clinical clinical trial conducted coronavirus coronavirus disease COVID-19 Diagnosis drug effective Efficacy enrolled evaluate evaluated groups High-flow nasal oxygen inhalation inhaler inhibit intravenous mechanical ventilation Mild-to-moderate multicenter nasopharyngeal viral load Negative conversion Open-label Patient per day Phase 2 polymerase chain primary endpoint progression Quantitative Randomized Randomly receive Registration Respiratory failure reverse transcription SARS-CoV-2 SARS-CoV-2 viral shedding significantly higher significantly lower standard care study enrollment symptom onset therapy treat Treatment [DOI] 10.3390/jcm10163545 PMC 바로가기 [Article Type] Article
Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 ReplicationBrief Report Published on 2021-08-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Antiviral Antiviral agents Antiviral assays block caused COVID-19 demonstrated derivative disease enzyme inhibit SARS-CoV-2 inhibitor molecular target non-nucleotide inhibitor pandemic of COVID-19 polymerase Potential treatment RdRP Replication RNA RNA-dependent RNA polymerase SAR-CoV-2 SARS-CoV-2 significantly targets Viral RNA [DOI] 10.3390/v13081585 PMC 바로가기 [Article Type] Brief Report
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicaseArticle Published on 2021-08-112022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] Analysis Anti-viral Antiviral agents apo form ATP conformational change conserved COVID-19 pandemic crystal structure dataset drug target effective drug Helicase help identify in viral infected with SARS-CoV-2 lack mechanism Molecular medicine performed phosphate Protein Replication reveal SARS-CoV-2 SARS-CoV-2 nsp13 SARS-CoV-2 proteome Sequence conservation starting point structural biology Structure the SARS-CoV-2 treat viral replication X-ray crystallography [DOI] 10.1038/s41467-021-25166-6 PMC 바로가기 [Article Type] Article
Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524)Article Published on 2021-08-102023-08-29 Journal: bioRxiv [Category] E형 간염, [키워드] Antiviral agents Ebola virus Filovirus GS-441524 GS-5734 Hemorrhagic fever virus henipavirus HUH7 cells human small airway epithelial cells (HSAEC1-KT) human telomerase reverse-transcriptase (hTERT) immortalized microvascular endothelial cells (TIME) lipid prodrugs NCI-H358 cells Nipah virus ODBG paramyxovirus Remdesivir remdesivir nucleoside respiratory viruses SARS-CoV-2 VERO E6 cells [DOI] 10.1101/2021.08.06.455494 PMC 바로가기 [Article Type] Article