Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants새롭게 등장하는 SARS-CoV-2 변이체의 진화, 전파 방식 및 돌연변이 양상Research Article Published on 2021-08-312022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed B.1.1.7 B.1.1.7 lineage B.1.351 B.1.525 B.1.526 B.1.617.2 CDC circulating coronavirus D614G E484K effect on vaccines Effectiveness emerging variants evaluated Frequency Genome genomes geographical distribution geographical distributions highest include landscape Lineage lineages mode Mutation mutational landscape N501Y New P.1 P.2 provided public health respiratory SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spike protein the WHO today Transmission transmission pattern transmission patterns USA Vaccine variant variants variants of concern variants of interest VoC VOCs VOI VOIs WHO [DOI] 10.1128/mBio.01140-21 PMC 바로가기 [Article Type] Research Article
Mechanical activation of spike fosters SARS-CoV-2 viral infection스파이크의 기계적 활성화는 SARS-CoV-2 바이러스 감염을 촉진합니다Article Published on 2021-08-312022-09-11 Journal: Cell Research [Category] MERS, SARS, 변종, 진단, [키워드] accelerate ACE2 ACE2 binding Activation Anti-S1 antibody binding binding domain blocking antibody caused complex convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 pandemic D614G Detachment domain faster force host cell host cell membrane Host receptors Invasion Mechanical Molecular biology mutant Neutralizing outbreak Prevent Receptor-binding domain recognize reduce Rotation S1 subunit S1/S2 S2 subunit SARS-CoV-2 SARS-CoV-2 viral infection SARS2 Spike protein structural biology tensile tensile force therapeutic strategy variant Viral viral entry [DOI] 10.1038/s41422-021-00558-x PMC 바로가기 [Article Type] Article
Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan파키스탄의 첫 번째 코비드 -19 파에서 SARS-COV-2 게놈에서 관찰 된 더 높은 엔트로피Research Article Published on 2021-08-312022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, [키워드] (RdRp 5’ UTR Analysis B.1 B.6 Capital change clade clades COVID-19 D614G Diversity Evolution except for exhibited Genetic Genome genome sequence genomes glycoprotein highest investigated isolates Laboratory lead material Mutation mutation rate Mutation rates not significant pandemic Phylogeny Q57H RdRP relative Result RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 strain SARS-CoV-2 strains selection pressure sequence sequences Site spike spike glycoprotein stability strain Strains subsequent territory transmitted virus were used [DOI] 10.1371/journal.pone.0256451 PMC 바로가기 [Article Type] Research Article
Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2Immunology Published on 2021-08-302022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] A475V addition Against antibody Antibody neutralization authentic SARS-CoV-2 virus convalescent COVID-19 patients D614G demonstrated drug epitope exhibited functional mutant mutated mutation resistance NAb neutralization activity neutralization potency Neutralizing activity Neutralizing antibodies neutralizing antibody nine novel pseudovirus RBD binding RBD binding affinity recombined antibody reconstructed SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 neutralizing antibody screened Spike protein Spike proteins systemically therapeutic agent vaccine-induced immune response variant [DOI] 10.3389/fimmu.2021.715464 PMC 바로가기 [Article Type] Immunology
Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing SystemResearch Published on 2021-08-262022-10-27 Journal: Biological Procedures Online [Category] COVID-19, [키워드] ACE2 ACE2-expressing cells acute respiratory syndrome addition angiotensin converting enzyme antibody binding Cell coronavirus D614G HEK293T cell host cell in vitro In vitro cell-capture Infection inhibited Interaction investigation living cell molecular mechanism mutant provide receptor ACE2 Receptor binding domain Result S protein S1 protein SARS-CoV-2 SARS-CoV-2;spike protein Spike protein supplementary material System the Spike the spike protein variant viral entry wild type [DOI] 10.1186/s12575-021-00153-9 PMC 바로가기 [Article Type] Research
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker강력하고 광범위한 코로나바이러스 차단제로서의 ACE2 표적 단클론항체Article Published on 2021-08-252022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단, 치료제, [키워드] ACE2 affecting Alanine angiotensin B.1.1.7 B.1.351 B.1.617.1 binding blocked CDR3 clinical development coronavirus Coronaviruses COVID-19 cryo cryo-EM D614G domain Drug development entry receptor epitope Evolution HCoV HCoV-NL63 heavy chain human ACE2 human Angiotensin-converting enzyme in vitro Infection Infectious diseases live SARS-CoV-2 management mice monoclonal antibody multiple coronaviruses mutant non-human primate non-human primates P.1 physiological activities physiological activity Prophylactic provided residue SARS-CoV SARS-CoV-2 SARS-COV-2 infection Toxicity variant virus [DOI] 10.1038/s41392-021-00740-y PMC 바로가기 [Article Type] Article
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutationsResearch Article Published on 2021-08-212022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] accompanied Analysis ancestor B-cell Bangladesh China Chittagong circulating clade Clinical data Complete country COVID-19 COVID-19 pandemic CpG D614G Deletion Diagnosis downloaded Epidemiology epitope European country evade event Evolution functional genetic diversity Genome genome sequence Genome sequencing genomic change GISAID GISAID database Host immune response implication include India insertions isolate isolates less Missense Missense mutation MOST Mutation mutations Nextstrain nucleotide occurred ORF7a ORF8 gene P323L Pathogenesis PCR Phylogeny predict predicted prevalent RdRP reduce reference sequence Region reported reveal RT-PCR SARS-CoV-2 SARS-CoV-2 genome selective sequence severity single nucleotide variations Spike protein submitted synonymous T-cell target region the disease the SARS-CoV-2 virus unique variant viral clearance viral replication virus Wuhan [DOI] 10.1016/j.heliyon.2021.e07866 PMC 바로가기 [Article Type] Research Article
Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA LevelResearch Article Published on 2021-08-202022-10-28 Journal: Pathogens and Immunity [Category] COVID-19, [키워드] affecting Amino acid Analysis analyzed Anti-viral C-terminal change circulating clinical sample coding COVID-19 D614G database domain dominant examined Frequency generate Generation Genetic variant Genome Homologous recombination Host humans identify immune response increased expression indicate individual Level mechanism Mutation novel nucleocapsid nucleotide change occurred open reading frames polymorphism Potential resulting RNA RNA transcript RNA transcripts SARS-CoV-2 sequence strain sub-genomic RNA transcript the SARS-CoV-2 genome transcription-regulating sequence Transmissibility TRS turn variant Variation viral polymorphism virus [DOI] 10.20411/pai.v6i2.460 PMC 바로가기 [Article Type] Research Article
“Molecular Masks” for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus EntrySARS-CoV-2 바이러스 진입을 효과적이고 안전하게 차단하는 ACE2용 "분자 마스크"Article Published on 2021-08-202022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 applicability block blocked blood pressure cause Cell cell surface receptor Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G decrease derivative dimeric enzyme enzyme activity Health Health crisis Human human body human cell human cells Infection Interaction mutant normal blood pressure peptoids pseudovirus Regulation respiratory resulting Safe SARS-CoV-2 SARS-CoV-2 pseudovirus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein surface receptor these compound these compounds unique Vaccine virus [DOI] 10.3390/ijms22168963 PMC 바로가기 [Article Type] Article
A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptationSpike 유전자의 선택적 스윕은 SARS-CoV-2 인간 적응을 주도했습니다Article Published on 2021-08-192022-09-11 Journal: Cell [Category] Coronavirus, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive assays bat bats binding cellular receptor contributed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G D614G mutation domain emergence Evolution Genome glycosylation greater hACE2 higher affinity hosts human ACE2 human lung cell human lung cells human SARS-CoV-2 human-to-human transmission molecular molecular virology mutant Mutation Non-synonymous pandemic pangolins Positive selection predicted RBD related virus Replication reservoir SARS-CoV-2 selective selective sweep sequence severe acute respiratory syndrome Coronavirus Spike protein spillover sustained the Spike the spike protein Transmission variant viral adaptation wild-type [DOI] 10.1016/j.cell.2021.07.007 PMC 바로가기 [Article Type] Article