hACE2 – Page 21 – Communicable Diseases Research

Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2

조작된 ACE2 수용체 요법은 SARS-CoV-2의 돌연변이 탈출을 극복합니다

Article

Published on 2021-06-212022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료제,

[키워드] ACE2 ACE2 receptor administration Antibody therapy binding caused cell sorting Concentration Disulfide Effect escape mutant escape mutants Evidence evidence of fixing global pandemic hACE2 hamster hamsters Hoshino hydrogen hydrophobic packing Incubation interface lung medication medications Mutagenesis mutated Mutation neutralized overcome passages pathology protease Protease activity random mutagenesis RBD Receptor binding domain receptors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 mutations stability target therapeutic interventions therapeutic potential therapy Vaccinations Viral viral adaptation virus receptor virus titer virus titers wild type
[DOI] 10.1038/s41467-021-24013-y PMC 바로가기 [Article Type] Article

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

Research Article

Published on 2021-06-162022-10-04
Journal: Science Advances [Category] MERS, 바이오마커, 유전자 메커니즘, 치료제,

Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice

Article

Published on 2021-06-162023-07-01
Journal: Journal of Virology [Category] SARS,

[키워드] COVID-19 hACE2 K18 hACE2 transgenic mice ORF3a ORF6 ORF7a ORF7b ORF8 Pathogenesis SARS-CoV-2
[DOI] 10.1128/JVI.00402-21 PMC 바로가기

Attractive and repulsive residue fragments at the interface of SARS-CoV-2 and hACE2

Article

Published on 2021-06-152022-10-29
Journal: Scientific Reports [Category] COVID-19,

Atomistic De-novo Inhibitor Generation-Guided Drug Repurposing for SARS-CoV-2 Spike Protein with Free-Energy Validation by Well-Tempered Metadynamics

원자체 de-Novo 억제제 생성 유도 약물 용 약물 용도가 잘 정기 된 메타 아이미믹스에 의한 자유 에너지 검증을 갖는 SARS-COV-2 스파이크 단백질을위한 약물 용도.

Article

Published on 2021-06-142022-08-31
Journal: Chemistry, an Asian journal [Category] MERS, SARS, 신약개발, 치료제,

H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic mice

Research Article

Published on 2021-06-132022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, 신종인플루엔자,

A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens

Research article

Published on 2021-06-092022-10-05
Journal: iScience [Category] 비임상,

Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms

Article

Published on 2021-05-212022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] A549 cell absence Anti-spike antibody antibody screening bovine CD147 Cell cell line cell lines cell type cells cellular receptors condition coronavirus coronavirus disease COVID-19 enzyme expressing FBS fetal hACE2 HIV Human in viral infect involved LINE mRNA abundance Multiple neutralization overexpression Plasmid produced Protein pseudotyped pseudotyped SARS-CoV-2 pseudotyped SARS-CoV-2 virus Pseudotyped virus RBD receptor replication-competent SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 virus sensitivity serum Spectrum spike the receptor-binding domain the SARS-CoV-2 TMPRSS2 TMPRSS4 viral entry virus was used
[DOI] 10.3390/v13060953 PMC 바로가기 [Article Type] Article

Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza

Article

Published on 2021-05-202022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] SARS, 신종인플루엔자, 치료기술, 치료법,

Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice

미립자 물질 노출은 인간화 ACE2 마우스에서 SARS-CoV-2 감염에 대한 감수성을 악화시킵니다

Article

Published on 2021-05-182022-09-11
Journal: Zoological research [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adsorption angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 caused Chinese coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 case COVID-19 cases death demonstrated English enzyme epidemic risk epidemiological epithelial cell epithelial cells exacerbate exacerbated expression expression level global pandemic hACE2 hACE2 mice. humanized indicate Infection Instillation Lungs Mask mechanism mice outbreak Particulate Particulate matter pulmonary lesion pulmonary lesions SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry factor SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 spike protein Serine severe acute respiratory syndrome Coronavirus significantly increased Spike protein Spread surpassed susceptibility the SARS-CoV-2 TMPRSS2 transmembrane serine protease transmembrane serine protease 2 viral replication
[DOI] 10.24272/j.issn.2095-8137.2021.088 PMC 바로가기 [Article Type] Article