SARS-CoV-2 proteome microarray for COVID-19 patient sera profilingCOVID-19 환자 혈청 프로파일링을 위한 SARS-CoV-2 프로테옴 마이크로어레이Article Published on 2022-02-282022-09-12 Journal: STAR protocols [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Affinity purification Antibody Response Biotechnology Biotechnology and bioengineering build Cell clinical clinical protocol Complete coronavirus COVID-19 patient E. coli eukaryotic expression facilitate Health Sciences help IgG and IgM Immunity immunology include Microarray Protein Protein Biochemistry Protein expression and purification proteome proteomics protocol SARS-CoV-2 SARS-CoV-2 proteome sera were expressed [DOI] 10.1016/j.xpro.2022.101238 PMC 바로가기 [Article Type] Article
MALDI-TOF mass spectrometry of saliva samples as a prognostic tool for COVID-19Research Article Published on 2022-02-272022-10-30 Journal: Journal of Oral Microbiology [Category] COVID-19, [키워드] Accuracy approach Biomarkers clinics conditions COVID-19 COVID-19 severity dataset Diagnosis diagnostic disease implementation independent machine learning algorithm Patient Prognosis prognosis of diseases prognostic proteomic proteomics public health reported Result Saliva SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity and specificity specificity submitted tested therapy train model Vaccine [DOI] 10.1080/20002297.2022.2043651 PMC 바로가기 [Article Type] Research Article
COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19Review Published on 2022-02-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] addressed adopted biochemical COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 research COVID-19 signature COVIDomics Data integration Diagnosis Disease progression drug target discovery dysregulated effort human cells include Infection knowledge mechanism metabolites metabolomics multiomics mutations pandemic pathophysiological pathway Perspective Proteins proteomics provided Replication Research SARS-CoV-2 Scientific community signature Spread the SARS-CoV-2 therapeutic Vaccine [DOI] 10.3390/ijms23052414 PMC 바로가기 [Article Type] Review
A Novel COVID-19-Related Drug Discovery Approach Based on Non-Equidimensional Data ClusteringPharmacology Published on 2022-02-212022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome addressed approach caused Cluster cluster center generating Clustering conducted coronavirus inhibitor Coronavirus-2 COVID-19 defined drug drug candidate drug candidates effective effective antiviral treatment experiment generate Hierarchical induce inhibitor inhibitors iterative knowledge Kronecker product matrix norm molecular no significant effect non-equidimensional data clustering novel novel coronavirus disease PLPro proteomics provided SARS-CoV-2 SARS-CoV-2 Mpro Spread to define Treatment [DOI] 10.3389/fphar.2022.813391 PMC 바로가기 [Article Type] Pharmacology
Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19 Research Published on 2022-02-172022-10-05 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 치료기술, 치료법, [키워드] Activation acute respiratory syndrome Admission allele Analysis applied association B cell Biomarkers characterized children children with COVID-19 circulating Combination coronavirus COVID-19 develop disorder Gene Expression genetic susceptibility healthy control help HLA identify IFN immune immunopathological Inflammation Inflammatory MIS-C morbidity Mutation no correlation pathophysiology pediatric proteomics responses robust SARS-CoV-2 SARS-CoV-2 PCR single-cell Spike protein syndrome T cell T cell activation therapy Transient TRBV11-2 type I interferon [DOI] 10.1038/s41591-022-01724-3 [Article Type] Research
Review of Liquid Chromatography-Mass Spectrometry-Based Proteomic Analyses of Body Fluids to Diagnose Infectious DiseasesReview Published on 2022-02-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] applied approaches Bacteria Biomarker discovery bodily fluid Body body fluid Clinical characteristics clinical sample coronavirus disease COVID-19 diagnostic Diagnostic method human body Infectious disease invasive liquid mass spectrometry mass spectroscopy parasites pathogen Patient proteomics Rapid required reservoir review target viruses [DOI] 10.3390/ijms23042187 PMC 바로가기 [Article Type] Review
Protein Posttranslational Signatures Identified in COVID-19 Patient PlasmaCell and Developmental Biology Published on 2022-02-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] acute respiratory syndrome Analysis arginylation cause caused changes in contagious coronavirus Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 patient decrease disease Donor exploratory study global change global pandemic glycosylation healthy control Human Identified identify implicated include Infectious disease Modification occur Peptidomics performed Phosphorylation plasma sample posttranslational modifications Protein proteomic proteomics provide Regulation researcher resource SARS-CoV-2 SARS-COV-2 infection signature the patient Treatment virus [DOI] 10.3389/fcell.2022.807149 PMC 바로가기 [Article Type] Cell and Developmental Biology
Association of cardiometabolic microRNAs with COVID-19 severity and mortalityCOVID-19 중증도 및 사망률과 심혈관 대사성 microRNA의 연관성Fast-Track Original Article Published on 2022-02-102022-09-10 Journal: Cardiovascular Research [Category] 바이오마커, [키워드] acute phase acute phase response age association Biomarkers Blood BMI candidate Candidates cardiometabolic Cell cell activation Chain Reaction circulating miRNA circulating miRNAs Cohort combinations coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 severity D-dimer determine differentially expressed endothelial healthy control healthy controls hepatocyte ICU intensive care lead liver longitudinal samples marker microRNA MicroRNAs Mild miR-122 miRNA miRNAs moderate Mortality Multiorgan myeloperoxidase Myocyte neutrophil neutrophil count neutrophil counts neutrophil degranulation outcome parameter patients performed plasma Platelet polymerase chain polymerase chain reaction positive predictor Protein proteomics proteomics data Quantitative reduced reflect reverse transcription reverse transcription quantitative polymerase chain reaction RNA-Seq SARS-CoV-2 selected severity tissue tissue injury Trajectories troponin with COVID-19 [DOI] 10.1093/cvr/cvab338 PMC 바로가기 [Article Type] Fast-Track Original Article
Composition, Clinical Efficiency, and Mechanism of NHC-Approved “Three Chinese Medicines and Three Chinese Recipes” for COVID-19 TreatmentPharmacology Published on 2022-02-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Analysis approved Asian available data Baidu China Chinese clinical Clinical efficacy clinical study coronavirus disease Coronaviruses COVID-19 COVID-19 infection demonstrated disease Disease progression Effect effective Epidemic evaluate Evidence granules in vitro in vivo Infectious disease lack mechanism Medicine metabolomics molecular docking mortality rate MOST National Health Commission network pharmacology NHC potential mechanism predicted Prevent proteomics reducing san-yao san-fang significant effect Symptoms TCM three Chinese medicine and three Chinese recipes Traditional Chinese medicine traditional Chinese medicine (TCM) treat Treatment were used [DOI] 10.3389/fphar.2021.781090 PMC 바로가기 [Article Type] Pharmacology
Mass spectrometry and proteome analysis to identify SARS-CoV-2 protein from COVID-19 patient swab samplesArticle Published on 2022-02-022023-06-19 Journal: STAR protocols [Category] COVID19(2023년), MERS, SARS, [키워드] clinical protocol Health Sciences mass spectrometry Protein Biochemistry proteomics [DOI] 10.1016/j.xpro.2022.101177 PMC 바로가기