SARS-CoV-2 viral – Page 21 – Communicable Diseases Research

Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion

Short Communication

Published on 2020-12-082022-10-29
Journal: Oxford Open Immunology [Category] COVID-19,

SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study

의료 종사자의 SARS-CoV-2 혈청 유병률 및 무증상 바이러스 전파: 횡단면 연구

Article

Published on 2020-12-012022-09-12
Journal: Thorax [Category] MERS, SARS, 진단,

[키워드] 95% CI anti-SARS-CoV-2 antibodies Antibody Response Asian Asymptomatic Bame black blood sample clinical epidemiology criteria cross-sectional determine foundation future infection greater Health healthcare healthcare worker hospital identify illness Infection infection control intensive care media Nasopharyngeal swab NHS observation occur outcome participant positive potential participant Prevalence Proportion of participant recruited remained reported required respiratory infection Result risk SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 RNA SARS-CoV-2 seroprevalence SARS-CoV-2 viral Seroconversion serology Seroprevalence significantly increased significantly lower spike glycoprotein Symptom symptomatic tested Trust university venous viral infection were excluded with COVID-19 working
[DOI] 10.1136/thoraxjnl-2020-215414 PMC 바로가기 [Article Type] Article

Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease

중증 질환이 있는 COVID-19 환자의 질병 진행을 이해하기 위한 혈장 내 SARS-CoV-2 항원 및 항체의 초민감 직렬 프로파일링

Article

Published on 2020-12-012022-09-11
Journal: Clinical Chemistry [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus analyzed anti-SARS-CoV-2 Antigen Biomarker Blood changes in clearance clinical outcomes Clustering Combined Concentration coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 negative COVID-19 positive patients detect detectable Disease progression Hierarchical hierarchical clustering ICU admission identify Infection intubation longitudinal plasma samples molecule MONITOR N antigen nasopharyngeal nucleocapsid antigen nucleocapsid antigens Patient patients patients with COVID-19 PCR plasma plasma sample positive positive result Profiling quantified reported respiratory Respiratory failure RT-PCR test S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 S1 SARS-CoV-2 spike SARS-CoV-2 viral Seroconversion serological serological assays serology tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Simoa single molecule arrays statistically significant test results These data Viral Viral antigen viral antigens
[DOI] 10.1093/clinchem/hvaa213 PMC 바로가기 [Article Type] Article

Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)의 주요 프로테아제 억제에 필요한 보존된 상호작용

Article

Published on 2020-11-302022-08-31
Journal: Scientific Reports [Category] SARS, 신약개발, 치료제,

[키워드] 3CLpro active site acute respiratory syndrome addition Analysis analyzed antiviral drugs antivirals approved drugs carried catalytic caused ChEMBL cleavage cleavage process Compound compounds Concentration conserved coronavirus COVID-19 pandemic crystal crystal structures docking drug design DrugBank facilitate FDA-approved drug filtered focus H-bond interaction in silico in vitro inhibitor inhibitory inhibitory compounds Interaction library MPro occur predicted protease Protease activity required residues SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Mpro SARS-CoV-2 viral screened selected sequence Structure suggested tested the SARS-CoV-2 Viral Virology
[DOI] 10.1038/s41598-020-77794-5 PMC 바로가기 [Article Type] Article

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

SARS-CoV-2 상의 뉴클레오캡시드 단백질은 RNA가 풍부한 중합효소를 함유하는 축합물로 분리됩니다.

Article

Published on 2020-11-272022-09-10
Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Cell complex coronavirus COVID-19 pandemic cytoplasmic Efficiency ENhance etiologic agent generate Genome Granule high-density in vitro induce infected cells inhibition interfere Intrinsically disordered proteins mechanism modulate modulated nucleocapsid nucleocapsid protein pandemic Phosphorylation produced Protein recruit Replication replication efficiency respiratory RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus small molecule Small molecules Solution-state NMR stress granules structural biology the SARS-CoV-2 Transcription Viral viral genome viral membrane viral replication Viral RNA viral transcription virus viruses
[DOI] 10.1038/s41467-020-19843-1 PMC 바로가기 [Article Type] Article

SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles

Research Article

Published on 2020-11-272022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS,

[키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome BCA, bicinchoninic acid assay BSL-2 BSL-3 BSL-3 facilities circumvent competent conditions coronavirus DAB, 3,3′-Diaminobenzidine DMEM, Dulbecco’s modified Eagle’s medium EEA1, early endosome antigen 1 effort electron microscopy (EM) ERGIC, endoplasmic reticulum–Golgi intermediary complex FBS, fetal bovine serum genetic material global pandemic globe Golgi human cell human cells inaccessible inhibitor Laboratory LAMP1, lysosomal associated membrane protein 1 majority mechanism membrane bilayer MERS coronaviruses MERS-CoV, Middle East respiratory syndrome coronavirus ORFs, open reading frames pandemic PFA, paraformaldehyde producing Research resource SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 research SARS-CoV-2 viral SARS-CoV-2 VLP SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEM, scanning electron microscopy Spread structural protein TEM, transmission electron microscopy viral life cycle Viral protein Virology virus virus assembly virus budding virus entry Virus-like particle virus-like particle (VLP) VLPs VLPs, Virus-like particles WGA, wheat germ agglutinin Wuhan, China
[DOI] 10.1074/jbc.RA120.016148 PMC 바로가기 [Article Type] Research Article

Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review

Review

Published on 2020-11-242022-10-31
Journal: International journal for equity in health [Category] COVID-19,

[키워드] acute respiratory syndrome addition affecting breast milk Case report children Comorbidities Comorbidity complications conducted coronavirus coronavirus disease cough COVID-19 database death diagnosed with COVID-19 disorders distress fetal Fever Gestational diabetes highlight hypertensive implication indicate infected with COVID-19 infection control infectious disease transmission Long-term follow-up Maternal morbidity Mortality mother nausea Neonatal Neonate Newborn obesity observational study Obstetric management outcome outcomes pandemic Placenta positive Pregnancy Pregnant woman pregnant women Premature review RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral selected Symptom Symptoms systematic review tested Transmission understanding vertical transmission was performed
[DOI] 10.3390/healthcare8040511 PMC 바로가기 [Article Type] Review

SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated from CD4+ Cells from Healthy, Unexposed Polish Donors

Communication

Published on 2020-11-122022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] Asymptomatic BCG caused CD4+ CD4+ cell Cell cellular response Cellular responses changes in common cold coronavirus common cold Coronaviruses Course COVID-19 COVID-19 infection cross-reactivity Cytokine storm Cytokines death dependent on Deterioration exhibited explain expression healthy donor high variability IFN-γ IFNg Impaired Cellular Immunity induce Infection interferon gamma involved Lineage Mild symptom outbreak pathogenesis of COVID-19 Patient Population Protein reduction in SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 viral systemic inflammation Th1 Th1 lymphocyte Th1 response Th17 the SARS-CoV-2 virus vaccination
[DOI] 10.3390/vaccines8040673 PMC 바로가기 [Article Type] Communication

Potential mouth rinses and nasal sprays that reduce SARS-CoV-2 viral load: What we know so far?

Comments

Published on 2020-11-102022-10-31
Journal: Clinics [Category] COVID-19, SARS,

[키워드] nasal Potential reduce SARS-CoV-2 viral
[DOI] 10.6061/clinics/2020/e2328 PMC 바로가기 [Article Type] Comments

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

파파인 유사 프로테아제는 SARS-CoV-2 바이러스 확산 및 선천 면역을 조절합니다

Article

Published on 2020-11-012022-09-11
Journal: Nature [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral immune response antiviral immunity attenuate biochemical cleavage cleave cleaving complex contribute coronavirus crystal structure cytopathogenic effect domain dual enzyme functional generate high affinity highlight highlighting Host host protein host proteins immune responses impair implicated infected cells Infection Innate immunity Interaction interactions interferon interferon pathway interferon-stimulated gene IRF3 ISG15 maintain mechanism NF-κB NF-κB pathways Papain-like protease PLPro polyprotein post-translational modification promote protease Protein reduce regulate Regulation required respiratory responses reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral sequence identity severe acute respiratory syndrome Coronavirus specificity Spread suppress target therapeutic strategy type I interferon ubiquitin Viral viral replication viral spread
[DOI] 10.1038/s41586-020-2601-5 PMC 바로가기 [Article Type] Article