Label-Free Plasmonic Biosensor for Rapid, Quantitative, and Highly Sensitive COVID-19 Serology: Implementation and Clinical Validation신속하고 정량적이며 매우 민감한 Covid-19 혈청학을위한 라벨이없는 플라즈몬 바이오 센서 : 구현 및 임상 검증Article Published on 2021-12-312022-09-10 Journal: Analytical Chemistry [Category] Fulltext, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification anti-SARS-CoV-2 antibody biosensor clinical clinical samples coronavirus COVID-19 COVID-19 pandemic Detection limit diagnostic diagnostic sensitivity diagnostics epidemiological Immunity Immunoglobulin immunological Laboratory management N protein negative sample offer peptide polyclonal antibodies positive quantification Rapid RBD respiratory SARS-CoV-2 sensitive sensitivity serological serological test Serological tests serology severe acute respiratory syndrome Coronavirus specificity Surveillance the disease Treatment vaccination validation with COVID-19 [DOI] 10.1021/acs.analchem.1c03850 PMC 바로가기 [Article Type] Article
Humoral immune response to SARS-CoV-2 in five different groups of individuals at different environmental and professional risk of infection감염의 다른 환경 및 전문적 위험에 처한 5 개의 다른 개인 그룹에서 SARS-COV-2에 대한 체액 면역 반응Article Published on 2021-12-302022-09-01 Journal: Scientific Reports [Category] 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antibody Response baseline Contact coronavirus COVID-19 COVID-19 disease diagnosed with COVID-19 disease Disease surveillance environmental exposure Epidemiology exposure to FIVE Follow-up Gender group immune response indicate individual Infection lockdown restriction lockdown restrictions Logistic regression analysis male multivariate multivariate logistic regression analysis persist positive positive individual positive individuals Primary outcome Quantitative Quantitative analysis quantitative test respiratory Risk factors risk of infection SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS‐CoV‐2 seroconversion rate serological severe acute respiratory syndrome Coronavirus significantly Symptom the median virus [DOI] 10.1038/s41598-021-04279-4 PMC 바로가기 [Article Type] Article
Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 자가항체 반응의 역설적인 성별 특정 패턴Research Published on 2021-12-302022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 진단, 치료법, [키워드] AABs absence Activation acute response age analyses antibody Antigen antigens assigned asymptomatic infection autoantibody autoantigen Autoantigen selectivity Autoimmune Autoimmune disease Autoimmune diseases autoreactivity blood draw breadth classic clinical disease Clustering Cohort collected COVID-19 COVID-19 illness demographic data effective intervention effective interventions Evidence evidence of exhibit extreme greater healthy control homology Immune-mediated inflammatory activity lead men men and women modulating molecular multivariable analyses nucleocapsid protein number of symptom participant presence or absence Prevalence reactivity reported symptom reported symptoms Result SARS-CoV-2 SARS-COV-2 infection serological severe COVID-19 illness Sex difference sex differences socio-demographic supplementary material susceptibility Symptom symptomatic infection Symptoms trajectory triggered within 6 months women [DOI] 10.1186/s12967-021-03184-8 PMC 바로가기 [Article Type] Research
T Cells Targeting SARS-CoV-2: By Infection, Vaccination, and Against Future VariantsMedicine Published on 2021-12-242022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Against antibody cellular response children crossreactivity elicited Future Immunity immunodominance Infection memory men recall recruitment reduced responses SARS-CoV-2 serological severe COVID-19 subset T cell T cell receptor T cell response T cells T follicular cell targeting tetramer Vaccine variants of concern viral clearance [DOI] 10.3389/fmed.2021.793102 PMC 바로가기 [Article Type] Medicine
Quantitative Analysis of SARS-CoV-2 Antibody Status between Patients with Cancer and Healthy Individuals with Extended Vaccination Dosing Intervals in Canada캐나다에서 연장된 백신 접종 간격을 가진 암 환자와 건강한 개인 간의 SARS-CoV-2 항체 상태의 정량적 분석Article Published on 2021-12-242022-09-12 Journal: Current Oncology [Category] SARS, 진단, [키워드] Analysis Anti-spike antibody antibody level AZD1222 binding antibody BNT162b2 Canada Cancer cancer patient Cancer patients Chemotherapy control group cross-sectional demonstrated domain dose Dosing ELISA enrolled enzyme-linked immunosorbent evaluate Extended group healthy hematological Hematological malignancy Humoral immunity IgG antibody individual interval knowledge mRNA-1273 Observed oncology participant Patient Protein response responses SARS-CoV-2 SARS-CoV-2 vaccine second dose serological serum significantly lower solid cancer solid cancer patients status the antibody response the healthy the mean the patient the SARS-CoV-2 therapy Treatment vaccination Vaccine [DOI] 10.3390/curroncol29010006 PMC 바로가기 [Article Type] Article
Evaluation of Three Quantitative Anti-SARS-CoV-2 Antibody Immunoassays3가지 정량적 항-SARS-CoV-2 항체 면역분석법의 평가Research Article Published on 2021-12-222022-09-10 Journal: Microbiology Spectrum [Category] SARS, 진단, 치료기술, [키워드] (Abbott Abbott acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody titer Antibody titers Antigen binding antibodies caused Chemiluminescent assay convalescent plasma coronavirus correlated correlation COVID Critical detect determine DiaSorin ELISA evaluated herd immunity house identify IgG Immunity immunization immunoassay Infection International international standard less LIAISON Live virus monoclonal antibodies Neutralization assay Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers NIBSC not correlated pandemic performed Postinfection proportional bias Protective respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 strain sensitivities sensitivity sera serological Serological assay serological assays serological result serological results severe acute respiratory syndrome Coronavirus significantly Specificities specificity spike tested the immunoassay the SARS-CoV-2 Treatment vaccination virus neutralization assay virus neutralization assays Virus spike WHO [DOI] 10.1128/spectrum.01376-21 PMC 바로가기 [Article Type] Research Article
Immune Responses to SARS-CoV-2 Infection and Vaccination in Dialysis Patients and Kidney Transplant RecipientsArticle Published on 2021-12-212022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody antibodies AZD1222 BNT162b2 booster cellular Cellular immune response Cohort convalescent patient coronavirus COVID-19 COVID-19 vaccination criterion detectable dialysis elicited healthy individual healthy individuals humoral IgG titer immune immune response immune system immunization Immunosuppression independent risk factor initial interferon-γ Kidney disease kidney transplant Linear regression model medication mRNA-1273 Patient patient subgroup performed protection quantified reactivity receiving recipient recipients response Retrospective analysis SARS-CoV-2 separated Seroconversion seroconversion rate serological significantly lower titer Transplant vaccination [DOI] 10.3390/microorganisms10010004 PMC 바로가기 [Article Type] Article
Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid proteinSARS-CoV-2 뉴클레오캡시드 단백질의 도메인 특이적 생화학적 및 혈청학적 특성화Article Published on 2021-12-172022-09-11 Journal: STAR protocols [Category] MERS, SARS, 진단, 치료법, 치료제, [키워드] binding biochemical Biology Biophysics clinical clinical protocol Complete deuterium electron microscopy evaluate expression Health Sciences hydrogen immunology include interferon interferon signaling life cycle mass mass spectrometry Microbiology Microscopy modulation Molecular biology negative-stain electron microscopy Nucleocapsid proteins nucleocapsids oligomerization Protein Protein Biochemistry protein expression Protein expression and purification protocol protocols purification regions reporter RNA SARS-CoV-2 life cycle SARS-CoV-2 nucleocapsid scattering Sensitivity and specificity serological serology structural biology [DOI] 10.1016/j.xpro.2021.100906 PMC 바로가기 [Article Type] Article
Development of an Indirect ELISA Based on Spike Protein to Detect Antibodies against Feline CoronavirusArticle Published on 2021-12-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Analysis antibodies antibody Antigen Antisera can be used cause characteristic China Clinical diagnosis coronavirus cross-react demonstrated detect develop development Diagnosis diagnostic disease ELISA enzyme-linked immunosorbent epidemiological expressed feline coronaviruses immunized pathogenic virus Population positive prevalent produced Protein Recombinant spike protein S protein sensitivity serological serum serum epidemiology serum sample specificity spike Spike protein tested Variation viruses [DOI] 10.3390/v13122496 PMC 바로가기 [Article Type] Article
Myocardial Injury Complicated by Systolic Dysfunction in a COVID-19-Positive DogCase Report Published on 2021-12-082022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] acute respiratory syndrome affected canine cardiological Case report cause characterising Charle clinical picture Clinical sign closely resemble concerning conducted contribute coronavirus coronavirus disease COVID-19 described diagnosing Diagnosis diagnostic dilated cardiomyopathy phenotype disease manifestation Diseases dog dysfunction echocardiography epidemiological survey Human Infection infective King knowledge Local manifested molecular test Myocardial myocardial injury myocarditis pandemic performed Result SARS-CoV-2 SARS-COV-2 infection serological simple Spread supported susceptible Symptom Syncope systolic ventricular viral disease zoonotic origin [DOI] 10.3390/ani11123506 PMC 바로가기 [Article Type] Case Report