Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine CoronavirusPathogenesis and Immunity Published on 2020-09-302022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] Adaptive immune response addition Analysis Antiviral approach Brain C57BL/6 CD45 Cell cellular pathway Central nervous system Central nervous system infections CNS contributing to coronavirus Critical Defense defined Demyelination disease Diversity effective evaluate expressed expressing heterogeneity Host host defense identify Immune cell immune response Immune-mediated immunological immunological mechanism immunology infecting Infection Intracranial involved landscape macrophages mice microglia molecular molecular network mouse hepatitis virus mRNA expression profile murine nervous nervous system Neuroimmunology neurologic neurotropic pathway RNA scRNAseq Single-cell RNA sequencing Stage subset susceptible System the Coronaviridae understanding unique viral infection viral persistence viral replication virus [DOI] 10.1128/JVI.01295-20 PMC 바로가기 [Article Type] Pathogenesis and Immunity
A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling ApproachArticle Published on 2020-09-182022-10-28 Journal: Biology [Category] COVID-19, [키워드] accelerate Adaptive immune response adjuvant Analysis approved B-cell candidate cause caused checked China Comprehensive coronavirus COVID-19 demonstrated development Efficacy Escherichia coli expression globe Helicase help immunization in silico In silico cloning include infections initial Interaction lack linkers molecular molecular dynamics Molecular dynamics simulation molecular interaction Molecular modeling multiepitope vaccine multiple epitope non-structural protein novel Novel coronavirus outbreak pandemic Pathogens peptide polymerase Prophylactic protease protective immunity Repurposed drugs Research SARS-CoV-2 SARS-CoV-2 protein severe respiratory infection simple solution Spike protein Spread stability T-cell epitope three-dimensional structure TLRs Toll-like receptor Treatment triggering urgency Vaccine vaccine construct Vaccine design Vaccine development vaccine production Vaccines virus was used World Health Organization [DOI] 10.3390/biology9090296 PMC 바로가기 [Article Type] Article
Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine DevelopmentBacillus Calmette-Guérin의 교훈: 백신 개발을 위한 훈련된 면역 활용Review Published on 2020-09-162022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, 진단, [키워드] Adaptive immune response adaptive immune responses Bacillus Bacillus Calmette-Guérin (BCG) Bacillus Calmette-Guérin BCG development Effect evade examined expand immune responses Immunity IMPROVE induce Infection innate immune innate immune memory lesson lower mortality mechanism microbe mucosal immunity Mycobacterium tuberculosis paradigm Pathogens pathway phenotype required target pathogen Tuberculosis Vaccine Vaccine design Vaccines [DOI] 10.3390/cells9092109 PMC 바로가기 [Article Type] Review
Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognitionArticle Published on 2020-09-142022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] 3D structure ACE2 receptor binding Adaptive immune response antibody Antigen antigenicity complexes determine domain glycan glycans glycoprotein glycosylation Golgi HEK293 HEK293 cells HLA immune immunology Impact implication leukocyte Modification modulating molecular molecular weight notable peptide produced Protein Protein structure predictions reported representing reveal S glycoprotein S protein S trimer SARS-CoV-2 shielding Spike protein Structure the SARS-CoV-2 the SARS-CoV-2 virus Vaccine viruses [DOI] 10.1038/s41598-020-71748-7 PMC 바로가기 [Article Type] Article
Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patientsCOVID-19 환자에서 SARS-CoV-2와 항체 반응의 장기간 공존Article Published on 2020-09-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immune response adaptive immune responses Analysis antibody Antibody Response China common clinical symptoms coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient did not produce examined IgG immune responses Immunity Infection Innate immunity Mild Patient patients respiratory SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe symptom severe symptoms shown Spread subset Virus-specific IgG [DOI] 10.1002/jmv.25946 PMC 바로가기 [Article Type] Article
Case Report: Canakinumab for the Treatment of a Patient With COVID-19 Acute Respiratory Distress SyndromeImmunology Published on 2020-08-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory distress syndrome Adaptive immune response bacterial superinfection canakinumab CD56 Cell compassionate use condition correlated COVID-19 cytokine cytokine levels Cytokine release syndrome Cytokine storm died expressing high risk hospital Hospitalization IL-1 IL-1β IL-6 IL-6 level immune cells Infection interleukin-6 Intubated Lung inflammation Lymphocyte count male monoclonal antibody Multiorgan natural killer NK cell Patient presenting reduced renal rescued respiratory SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity severe cases significantly subset syndrome Treatment with COVID-19 [DOI] 10.3389/fimmu.2020.01942 PMC 바로가기 [Article Type] Immunology
Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune ResponseImmunology Published on 2020-08-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activated Activation adaptive Adaptive immune response age all-cause mortality antibody-secreting cell antigenic caused change clinical consequence Combination complementary coronavirus disease COVID-19 Cytokine release syndrome Cytokine storm disease effective Efficacy elderly endothelial injury Enhancing explain follicular Frequency helper T cell immune response Immunity Immunopathogenesis immunosenescence Impact individual Infection Inflamm-aging inflammaging inflammatory state inhibiting innate immune response less management memory T cell naïve neo-antigens occur organ injury Patient Potential pro-inflammatory Prognosis remodeling response SARS-CoV-2 severe COVID-19 susceptible T cell Therapeutic approach thought tissue damage triggered vaccination viral replication virus [DOI] 10.3389/fimmu.2020.01748 PMC 바로가기 [Article Type] Immunology
Dysregulated adaptive immune response contributes to severe COVID-19Letter to the Editor Published on 2020-08-052022-10-04 Journal: Cell Research [Category] MERS, SARS, 치료제, [키워드] Adaptive immune response contribute immunology severe COVID-19 Transcription [DOI] 10.1038/s41422-020-0391-9 PMC 바로가기 [Article Type] Letter to the Editor
A gendered magnifying glass on COVID-19Review Published on 2020-08-042022-11-01 Journal: Clinical and Molecular Allergy : CMA [Category] COVID-19, [키워드] ACE2 Adaptive immune response affecting age Anti-viral COVID-19 cytokine release death defend Efficiency expression female Gender hallmark IL-6 immunological Inflammation involved male males morbidity and mortality Pandemia pathogen PRRs receptor recognize regulated Regulation SARS-CoV-2 SARS-COV-2 infection several gene Sex Sex difference ssRNA Support TLR7 TMPRSS2 toll-like receptor 7 X chromosome [DOI] 10.1186/s12948-020-00129-2 PMC 바로가기 [Article Type] Review
Viral Evasion of the Complement System and Its Importance for Vaccines and TherapeuticsImmunology Published on 2020-07-092022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptive Adaptive immune response Antiviral effect antivirals chemotaxis complement complement system COVID-19 pandemic dengue virus disease disease symptoms dysregulation Effective vaccines Effects ENhance evade exacerbate Extracellular Factor functions Genetic host response Immunity immunology Importance induce Inflammatory responses Innate immunity Interaction mechanism microorganisms neutralization Nipah virus occur outcome Pathogenesis Pathogens pathway PROTECT Regulation Research respond Stage System Therapeutics this system Vaccines viral infection viral infections viral infectivity Virology virus viruses West Nile Virus [DOI] 10.3389/fimmu.2020.01450 PMC 바로가기 [Article Type] Immunology