human ACE2 – Page 22 – Communicable Diseases Research

Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2

Virus-Cell Interactions

Published on 2020-07-132022-10-30
Journal: Journal of Virology [Category] COVID-19, MERS,

[키워드] ACE2 ACE2 ortholog activities amplifying animal animal ACE2 Animal host animal hosts animal models bat caused cleavage coronavirus Coronaviruses COVID-19 pandemic CoVs determine effort Entry examined exhibited furin furin cleavage furin cleavage site global public health glycoprotein highest host cell host cells host range hosts human ACE2 human Angiotensin-converting enzyme human-to-animal transmission implication infect cells Infection Interaction Lentiviral particle lowest molecular basis Mutant SARS-CoV-2 pangolins Pathogenesis polybasic pseudotyped Pseudotyped virus receptor Receptor binding reservoirs S protein SARS-CoV-2 SARS-CoV-2 S protein Spike protein Support supported the S protein the S1 subunit tissue tropism Transmission Usage wild-type zoonotic transmission
[DOI] 10.1128/JVI.00940-20 PMC 바로가기 [Article Type] Virus-Cell Interactions

Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusion

Research Article

Published on 2020-07-092022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, SARS,

De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2

Research Paper

Published on 2020-06-302022-10-28
Journal: Aging (Albany NY) [Category] COVID-19,

COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice

Review

Published on 2020-06-042022-10-31
Journal: Human Genomics [Category] COVID-19, SARS,

Cell entry mechanisms of SARS-CoV-2

530

Published on 2020-05-262022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

[키워드] ACE2 receptor activated Activation acute respiratory syndrome bind binding affinity biochemical Cell cell entry cells comparable contribute coronavirus coronavirus disease COVID-19 domain Entry mechanism entry receptor feature furin hACE2 hidden highlighting human ACE2 human cell immune immune evasion Intervention investigated less maintain mechanism mechanisms pandemic proprotein convertase furin protease Proteases provide pseudovirus entry assay pseudovirus entry assays RBD receptor Receptor binding reducing SARS-CoV SARS-CoV RBD SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 RBD SARS-CoV-2 spike second Significance Spike protein Spread Surveillance the RBD understanding virus
[DOI] 10.1073/pnas.2003138117 PMC 바로가기 [Article Type] 530

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Article

Published on 2020-05-152022-11-01
Journal: Cellular and Molecular Immunology [Category] COVID-19, SARS,

[키워드] ACE2 against SARS-CoV amino acid residue analyzed angiotensin-converting enzyme 2 antibody antigenic bind binding site block viral entry caused Coronavirus disease 2019 coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic cross-neutralizing cross-neutralizing antibody develop drug epitope F486 feature host receptor human ACE2 Humoral immunity immunization in vivo experiment indicate induce Infection mechanism neutralize Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibody Prophylactic public health RBD receptor binding motif recognize representing residue SARS-CoV SARS-CoV RBD SARS-CoV-2 SARS-CoV-2 RBD Spike protein Substitution mutation the RBD the receptor-binding domain the SARS-CoV-2 the spike protein Vaccine viral spike protein viruses
[DOI] 10.1038/s41423-020-0458-z PMC 바로가기 [Article Type] Article

The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues

Brief Report

Published on 2020-05-142022-10-29
Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS,

SARS‐CoV‐2, an evolutionary perspective of interaction with human ACE2 reveals undiscovered amino acids necessary for complex stability

Original Article

Published on 2020-05-072022-10-31
Journal: Evolutionary Applications [Category] COVID-19,

[키워드] ACE2 Amino acid Analysis Betacoronavirus betacoronavirus spike protein binding cell receptor complex conserved coronavirus Critical death determine directional effective ENhance evolutionary dynamics Factor FIVE genomic region glycine hACE2 host cells human ACE2 human cell human cells human host implicated IMPROVE infect Infection infections inhibiting binding Interaction modeling molecular dynamics performed Perspective Positive selection predict purifying selection receptor receptor ACE2 receptor‐binding domain residue reveal Salt Bridge SARS‐CoV‐2 SARS‐CoV‐2 selection pressure spike glycoprotein Spike protein stability viral evolution viral lineages viral spike protein virus
[DOI] 10.1111/eva.12980 PMC 바로가기 [Article Type] Original Article

Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

Article

Published on 2020-04-242022-10-04
Journal: Nature Communications [Category] SARS, 치료제,

[키워드] ACE2 acute respiratory syndrome Antiviral treatment binding affinity binding kinetics catalytic activity cell entry receptor characterized coronavirus Coronaviruses cross-reactivity determine Diagnosis domain enzyme Extracellular Fc region fusion protein generate human ACE2 human immunoglobulin IgG1 in vitro inhibit mice mutant neutralize parameter pharmacological Prophylaxis Protein pseudotyped Pseudotyped virus receptor Recombinant protein therapy SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARSCoV-2 shown Spike protein the receptor-binding domain Treatment Vaccine viral infection virus Wuhan, China
[DOI] 10.1038/s41467-020-16048-4 PMC 바로가기 [Article Type] Article

Origin, Potential Therapeutic Targets and Treatment for Coronavirus Disease (COVID-19)

Review

Published on 2020-04-222022-10-28
Journal: Pathogens [Category] COVID-19,

[키워드] ACE2 blocker affecting angiotensin-converting enzyme 2 Anti-inflammatory antibodies antimalarial Antiviral bat challenges Characteristics cleavage coronavirus coronavirus disease COVID-19 cumulative disease event Health herbal medicines Host human ACE2 humans information inhibitors Interaction Novel coronavirus origin pandemic status Pathogenesis pathophysiology plasma Potential potential therapeutic targets provide receptor Research RNA genome SARS-CoV SARS-CoV-2 serine protease single-stranded positive-sense Spike protein spike protein-based vaccines subsequent target the SARS-CoV-2 therapeutic potential Therapeutics transmitted treated Treatment Vaccine virus
[DOI] 10.3390/pathogens9040307 PMC 바로가기 [Article Type] Review