COVID-19 Infection and Neuropathological FeaturesOpinion Published on 2021-10-112022-10-29 Journal: Medicines [Category] COVID-19, [키워드] acute respiratory syndrome Airway inflammation assessment autoantibodies Course COVID-19 COVID-19 infection cytokine release Diffuse alveolar damage Infection infections MERS-CoV Neuroinflammation Neuropathology pathology public health recent SARS-CoV Topic triggered with COVID-19 [DOI] 10.3390/medicines8100059 PMC 바로가기 [Article Type] Opinion
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells새로운 종류의 TMPRSS2 억제제는 SARS-CoV-2 및 MERS-CoV 바이러스 진입을 강력하게 차단하고 인간 상피 폐 세포를 보호합니다410 Published on 2021-10-112022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 신약개발, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antiviral antiviral drug block broad-spectrum antivirals Calu Calu-3 calu-3 cells camostat can be used cell entry chimeric clinical development coronavirus COVID-19 COVID-19 treatment Cytopathic effect cytopathic effects drug drug candidate drug design Drug discovery drugs Efficacy epithelial epithelial cell epithelial cells full-length half-life half-maximal effective concentration half-maximal inhibitory concentration help host cell human lung in vivo Influenza influenza viruses inhibiting inhibitor lead lung lung cell lung tissue mechanism MERS-CoV mice Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus nafamostat other coronavirus other coronaviruses Pathogenesis pharmacokinetics plasma probe protease Protease inhibitor PROTECT Protein PS-SCL respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 virus selective Serine serine protease TMPRSS2 severe acute respiratory syndrome Coronavirus Significance significantly specificity Spike protein stability structure-based drug discovery the Spike therapeutic target TMPRSS2 TMPRSS2 inhibitor TMPRSS2 inhibitors TMPRSS2 protein treat Treatment Viral viral entry viral pathogenesis Viral protein viral spread virus [DOI] 10.1073/pnas.2108728118 PMC 바로가기 [Article Type] 410
Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion PeptidesArticle Published on 2021-10-102022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] alkaloid alkaloids alteration antiviral action antiviral therapy calcium cholesterol composed Compound concentrations coronavirus COVID-19 decrease demonstrated Effect effective Efficiency fluorescence microscopy fragment fusion fusion peptide greater in vitro indicated inhibit inhibitory investigated knowledge Lipid Mediated membrane membrane fusion MERS-CoV non-toxic Novel coronavirus pandemic peptides Phosphatidylcholine physical piperine plant Prevent progeny reduce SARS-CoV2 scattering shown significant changes in significantly suppress tested Vero Cell Vesicle viral fusion inhibitor [DOI] 10.3390/biomedicines9101434 PMC 바로가기 [Article Type] Article
Global Diversification and Distribution of Coronaviruses With Furin Cleavage SitesMicrobiology Published on 2021-10-072022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] addition Animal host bovine Cell cleavage sites coronavirus Coronaviruses country CoV COVID-19 COVID-19 pandemic CoVs diversification Epidemiology event examined explain FIVE furin furin cleavage site Germany glycoprotein HCoV-HKU1 HCoV-OC43 Human humans hydrolysis infect MERS-CoV outbreak plasma membrane required SARS-CoV-2 Site [DOI] 10.3389/fmicb.2021.649314 PMC 바로가기 [Article Type] Microbiology
Evolution of RNA viruses from SARS to SARS-CoV-2 and diagnostic techniques for COVID-19: a reviewReview Published on 2021-10-062022-10-28 Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19, [키워드] affecting Blood caused chemiluminescent immunoassay Chest clinical manifestations Computed tomography Contact tracing coronavirus COVID-19 CREST CRISPR described Diagnosis diagnostic diagnostics disease enzyme-linked immunosorbent Evolution Final Genome Human isothermal amplification Laboratory test Lateral majority management MERS MERS-CoV Neutralization assay nucleic acid outbreak parameter precautions RNA RNA virus SARS SARS-CoV SARS-CoV-2 Sequencing serological test Spread ssRNA viruses subsequent the disease Therapies Transmission Trial viral genome viral outbreak virulence virus X-ray [DOI] 10.1186/s43088-021-00150-7 PMC 바로가기 [Article Type] Review
Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine OrthoreovirusArticle Published on 2021-10-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 bat bats Characteristics characterized Culture Ebola Ebola virus epithelial filoviruses Health Hendra virus Host Infection intestinal intestinal organoid long-term stable culture MERS-CoV Middle East morphology natural host Nipah virus Organoid pathogen Pathogens respiratory Rousettus SARS-CoV SARS-CoV-2 sensitivity susceptibility thought TMPRSS2 tolerance mechanism virus virus susceptibility viruses [DOI] 10.3390/ijms221910763 PMC 바로가기 [Article Type] Article
Chest radiographic score and lactate dehydrogenase are independent risk factors linked to mortality in Middle East Respiratory Syndrome Coronavirus (MERS-CoV) patientsResearch Published on 2021-10-052022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] 95% CI adjusted age ARDS association average biochemical biochemical parameter Blood C-statistic changes in chest radiographic cut-off value death Deceased elevated greater hazard hospital in-hospital mortality independent risk factor individual lactate dehydrogenase LDH log MERS-CoV MERS-CoV infection Middle East Mortality multivariate outcome Patient predict prediction protective factor Radiographic regression analysis respiratory Result retrospective cohort risk factor sensitivity serum specificity threshold Ventilation [DOI] 10.1186/s43055-021-00635-6 PMC 바로가기 [Article Type] Research
Evaluation of a multiplexed coronavirus antigen array for detection of SARS-CoV-2 specific IgG in COVID-19 convalescent plasmaCOVID-19 회복기 혈장에서 SARS-CoV-2 특이 IgG 검출을 위한 다중 코로나바이러스 항원 어레이 평가Article Published on 2021-10-012022-09-11 Journal: Journal of Immunological Methods [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Antibody Response Antibody test Antibody titers Antigen Antigen array antigens comparable convalescent plasma convalescent plasma samples coronavirus COVID-19 COVID-19 pandemic cross-reactivity domain ELISA ELISAs Endemic evaluated Extracellular focus FRNT full-length HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HKU1 IgG IgG antibody Inc InDevR lack Live virus MERS MERS-CoV Mitigation Neutralizing activity neutralizing antibody neutralizing antibody titers NL63 nucleocapsid nucleocapsid IgG OC43 other coronavirus other coronaviruses plasma samples platform positive result positive sample proximal question reactivity Receptor binding domain reduction remained reported Sample SARS-CoV SARS-CoV spike SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-CoV-2 nucleocapsid Sensitivity and specificity significantly higher specificity spike Spike antigen the antibody response the SARS-CoV-2 while [DOI] 10.1016/j.jim.2021.113104 PMC 바로가기 [Article Type] Article
Harnessing recombinase polymerase amplification for rapid multi-gene detection of SARS-CoV-2 in resource-limited settings자원이 제한된 환경에서 SARS-CoV-2의 신속한 다중 유전자 검출을 위한 재조합효소 중합효소 증폭 활용Article Published on 2021-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] SARS, 변종, 치료기술, 치료제, [키워드] amplification analytical sensitivity complementary complexity conserved COVID-19 pandemic demonstrated detect develop diagnostic diagnostic test diagnostic testing Dipstick E gene equipment faster Genes gold gold standard isothermal amplification Laboratory limit MERS-CoV molecular Molecular assay molecular test Multi-gene nucleic acid testing offer PCR platform point-of-care polymerase RdRP RdRp gene reaction Real-time detection REcombinase recombinase polymerase amplification reverse transcription RNA copies RNA copy SARS-CoV SARS-CoV-2 SARS-CoV-2 genes seasonal coronaviruses Sensitivity and specificity specificity Spread target variants of concern virus [DOI] 10.1016/j.bios.2021.113328 PMC 바로가기 [Article Type] Article
Acute respiratory distress syndrome: a life threatening associated complication of SARS-CoV-2 infection inducing COVID-19급성 호흡곤란 증후군: COVID-19를 유발하는 SARS-CoV-2 감염의 생명을 위협하는 관련 합병증Review Published on 2021-10-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] accompanied ACE2 acute respiratory distress syndrome alveolar capillary alveolar damage ARDS biochemical caused chest radiological coronavirus COVID-19 damaged death Diffuse alveolar damage diffuse inflammation Disruption distress edema Endothelium expression feature Human Hypoxemia IL-1 IL-6 include infect Inflammation inflammatory mediator Inflammatory mediators Injury life threatening lung tissue mechanism membrane MERS-CoV outbreak PaO pathological mechanism pathophysiological pathophysiology prognostic provoke Pulmonary edema pulmonary parenchyma respiratory respiratory distress Respiratory distress syndrome Respiratory failure SARS-CoV SARS-CoV-2 SARS-COV-2 infection Seven severe COVID-19 severe disease severe pneumonia TNFα viral infection worsening [DOI] 10.1080/07391102.2020.1803139 PMC 바로가기 [Article Type] Review