mononuclear cell – Page 22 – Communicable Diseases Research

Suboptimal SARS-CoV-2−specific CD8 + T cell response associated with the prominent HLA-A*02:01 phenotype

530

Published on 2020-09-292022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine

Review Article

Published on 2020-09-252022-10-29
Journal: Journal of Immunology Research [Category] Coronavirus, MERS, SARS,

S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 Subunit

Research Article

Published on 2020-09-252022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] accompanied acute respiratory syndrome Analysis analyzed anti-N IgG anti-S2 antibody antibody production asked B cell B cell response circulating conserved convalescent coronavirus coronavirus disease correlated strongly COVID-19 cross-reactive disease ENhance frequencies generate healthy donor Human human coronavirus OC43 IgG IgG antibodies IgG level IgG titer immune memory immune protection Immunity individuals Infection MBC memory B cell memory B cells mononuclear cell MOST non-SARS-CoV-2 protein nucleocapsid pandemic PBMCs Peripheral blood Population Postinfection Production Protein provide RBD reactive Receptor binding domain reflect Reinfection S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera specificity Spike protein Spread subject subjects susceptibility susceptible the RBD the S protein the SARS-CoV-2 virus Virus-specific IgG
[DOI] 10.1128/mBio.01991-20 PMC 바로가기 [Article Type] Research Article

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Research Articles

Published on 2020-09-172022-10-28
Journal: Science Immunology [Category] COVID-19, Fulltext, SARS,

[키워드] alteration Analysis Bone marrow CD14 Cell cellular clinical disease COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient disease driving elevated enzyme exaggerated immune response expression feature Hospital admission hospitalized patient identify IL-6 immune immune profiling immune response immune signature inflammatory component innate immune IP-10 longitudinal marker MCP-1 median modulation monocyte mononuclear cell myeloid cell neutrophil outcome Patient PBMCs Peripheral blood phenotype reveal serum severe disease severity of COVID-19 Support T cell the healthy therapeutic strategy therapy timepoints Whole blood with COVID-19
[DOI] 10.1126/sciimmunol.abd6197 PMC 바로가기 [Article Type] Research Articles

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Research Article

Published on 2020-09-042022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS,

[키워드] activated activating Activation acute COVID-19 acute respiratory syndrome acute viral infection adaptive immune responses affected Analysis Antiviral antiviral response approach available data B cell responses B cell subset B cells Blood caused CD38 CD4 CD4 T cells CD8 CD8 T cell CD8 T cells cells characteristic characterized circulating Clinical data clinical feature Clinical features clinical outcomes collected comparable complex component controls coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 severity Cytometry declined deep dimension disease disease severity Donor dysregulation Effective vaccines effector memory exacerbate fatality feature Features flow cytometry fluctuation follicular global pandemic Health healthy donor healthy individual healthy individuals help HLA-DR Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients human immune response Human immune system identify immune Immune cell immune modulation immune parameter immune profiling immune response immune system immunological immunology immunotype implicated implication in some individuals Infection infections influence information inhibiting less longitudinal analysis lymphocyte lymphocyte response mechanical ventilation memory B cell mononuclear cell occurred parameters Pathogenesis Patient patients performed peripheral plasmablast plasmablast response progression proliferation proportion remained respond response reveal robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–specific antibodies Science severe respiratory disease stability STABLE subgroup of patient subset Systems biology T cell T cell activation T cell response therapeutic therapeutic interventions trajectory Treatment UMAP uninfected Vaccine virus with COVID-19
[DOI] 10.1126/science.abc8511 PMC 바로가기 [Article Type] Research Article

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Research Article

Published on 2020-09-042022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome affected analyzed Antigen approach Atlanta Bacterial coronavirus Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity disease disease severity expression flow cytometry healthy individual healthy individuals HLA-DR Hong Kong hospitalized COVID-19 patient Human Human immune system human immunity IFN-stimulated genes IFN-α Immune cell immune modulation immune response immune system Immunity immunotype Infection Inflammatory influence information Interferon-α knowledge lack leukocyte mammalian mechanism Mild mononuclear cell myeloid cell parameters Patient PBMC PBMCs performed Peripheral blood plasma plasmacytoid dendritic cells potential therapeutic target Proinflammatory cytokine Rapamycin reduced respond response SARS-CoV-2 Science severe COVID-19 Severe COVID-19 Infection Signaling Single-cell transcriptomics System Systems biology therapeutic interventions TNFSF14 transcriptomics transient expression type I IFNs United States with COVID-19
[DOI] 10.1126/science.abc6261 PMC 바로가기 [Article Type] Research Article

Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

Research Article

Published on 2020-09-032022-10-30
Journal: JCI Insight [Category] COVID-19, SARS,

[키워드] adaptive Adaptive immunity Administered Blood canonical COVID-19 COVID-19 infection COVID-19 infections COVID-19 patient COVID-19 patients Critically ill cytokine Cytokine storm diagnostic dissemination Elevation ELISPOT evaluate Ex vivo functional healthy control Host host immunity host response Hyperinflammatory hypothese Hypothesis IL-6 level IL-7 immune effector cell immune function immunoassay Immunosuppression immunosuppressive innate immune Innate immunity lack less monocyte mononuclear cell morbidity and mortality organ injury pathologic Patient patients patients with COVID-19 produced proinflammatory cytokines protective immunity reduced restored Sepsis stimulated Support suppresse T cell T cell subset Therapies TNF-α Volunteer
[DOI] 10.1172/jci.insight.140329 PMC 바로가기 [Article Type] Research Article

COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

Article

Published on 2020-09-032022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단, 치료제,

Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2

Research

Published on 2020-09-012022-10-31
Journal: Emerging Infectious Diseases [Category] COVID-19, SARS,

Presence of Genetic Variants Among Young Men With Severe COVID-19

Case Reports

Published on 2020-08-182022-10-04
Journal: JAMA [Category] MERS, 변종,

[키워드] acute respiratory syndrome affected age Analysis Blood carried case sery caused Cell chronic disease Control controls coronavirus coronavirus disease COVID-19 criteria died downregulated downstream experiments exposure Final finding Follow-up functional Genetic Genetic variant hospital ICU identify IFN IFN-γ IFNB1 immune defects immunodeficiency immunological Immunological test Importance individual intensive care interferon interferon signaling IRF7 ISG15 loss-of-function male measure mechanical ventilation Medical conditions men missense variant mononuclear cell mRNA expression Netherland Netherlands objective occur one patient participant pathogenesis of COVID-19 Patient patients patients hospitalized patients with COVID-19 performed Peripheral blood Point preliminary finding Presence primary immune cell Rapid Relevance responses Result SARS-CoV-2 setting severe coronavirus disease severe COVID-19 Severe infection Signaling significantly the mean the patient TLR7 transcriptionally type I type I interferon type II IFN variant ventilatory support whole-exome sequencing
[DOI] 10.1001/jama.2020.13719 PMC 바로가기 [Article Type] Case Reports