innate immune response – Page 23 – Communicable Diseases Research

Induction of the Proinflammatory Chemokine Interleukin-8 Is Regulated by Integrated Stress Response and AP-1 Family Proteins Activated during Coronavirus Infection

Article

Published on 2021-05-262022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

Time-dependent viral interference between influenza virus and coronavirus in the infection of differentiated porcine airway epithelial cells

Research Article

Published on 2021-05-252022-10-28
Journal: Virulence [Category] Coronavirus,

[키워드] aggravate Air-liquid interface air-liquid interface culture airway epithelial cell aminopeptidase N applied caused cellular cellular receptor circulating Clinical signs Co-infection Complete inhibition coronavirus Coronavirus infection Coronavirus replication Culture detectable determinant epithelial cell H3N2 Human implication Infection Influenza virus innate immune response intervals molecular mechanism porcine aminopeptidase N porcine respiratory coronavirus porcine respiratory disease complex receptor Replication Respiratory Coronavirus responsible SARS-CoV-2 Seasonal influenza SIV super-infection swine influenza virus the timing time intervals tracheal upregulation viral interference virus virus infection viruses
[DOI] 10.1080/21505594.2021.1911148 PMC 바로가기 [Article Type] Research Article

Association Between Bitter Taste Receptor Phenotype and Clinical Outcomes Among Patients With COVID-19

COVID-19 환자의 쓴맛 수용체 표현형과 임상 결과 사이의 연관성

Research

Published on 2021-05-252022-09-10
Journal: JAMA Network Open [Category] SARS, 변종,

[키워드] Adults age allelic variant allelic variants Analysis appear association Bitter bitter taste bitter tastes bitter tastes) can be used Chain Reaction clinical Clinical course Clinical practice cohort study confirmation COVID-19 determine evaluate exposure exposure to finding Genetic variation Genotype greater groups Health care health care workers hospital Hospitalization Hospitalized IgM and IgG implicated Importance individual infected with SARS-CoV-2 Infection infection with SARS-CoV-2 innate immune innate immune response Innate immunity inpatient admission intensity lack measure objective Odds ratio outcome outcomes participant participated pathogen Patient PCR PCR testing phenotype Point polymerase chain polymerase chain reaction positive positive PCR test positive result Prognosis prospective cohort study Randomly ranged receptor Relevance required respiratory Result SARS-CoV-2 SARS-COV-2 infection selected setting significantly more susceptibility symptom duration symptomatic Symptoms Taste Taste receptor test results tested the United State United States upper respiratory tract Variation was performed with COVID-19 women
[DOI] 10.1001/jamanetworkopen.2021.11410 PMC 바로가기 [Article Type] Research

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection

Research Article

Published on 2021-05-242022-10-29
Journal: PLoS Pathogens [Category] COVID-19,

[키워드] Adaptive immune response anti-inflammatory cytokine anti-inflammatory effect antiviral drug Asymptomatic Asymptomatic carriers CCL2 CCL3 chemokine clearance clinical manifestation Concomitant contribute correlated Cytokine storm disease driving effective elicited epithelia etiological agent expression feature high mortality Host humans IFN IL10 immune response gene immunological pathway Infection Infectious virus infiltration Inflammation Inflammatory responses innate immune response interferon interferon response interferons (IFNs ISG ISGs lethal disease leukocyte leukocytes lung MERS-CoV MERS-CoV infection Middle East Mild mucosa nasal nasal mucosa NF-κB post inoculation pro-inflammatory cytokine pro-inflammatory gene produced provoke Regulation reservoir Respiratory disease respiratory syndrome coronavirus respiratory tract Simultaneous stimulated syndrome tissue damage tissues transcribed Transcription transcriptional regulation triggering Type type I Type III IFN understanding upregulation Vaccines viral infection virus virus clearance while
[DOI] 10.1371/journal.ppat.1009229 PMC 바로가기 [Article Type] Research Article

Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries

Article

Published on 2021-05-232022-10-31
Journal: Cells [Category] COVID-19, Fulltext, SARS, 조류인플루엔자,

Dolosigranulum pigrum Modulates Immunity against SARS-CoV-2 in Respiratory Epithelial Cells

Communication

Published on 2021-05-212022-10-28
Journal: Pathogens [Category] COVID-19,

[키워드] Dolosigranulum pigrum Activation addition Administered Calu-3 cell CCL5 cellular damage combating commensal bacteria coronavirus coronavirus 2 Coronavirus infection COVID-19 culture supernatant CXCL10 CXCL8 cytokine profile demonstrated evaluate IFN-β IL-6 Immunity immunological mechanism immunomodulatory effect IMPROVE innate immune response involved mice modify modulated modulation next generation probiotics reducing reduction in respiratory respiratory commensal bacteria respiratory epithelial cell respiratory epithelial cells RSV SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 stimulated strain TLR3 Toll-like receptor 3 triggered viral replication
[DOI] 10.3390/pathogens10060634 PMC 바로가기 [Article Type] Communication

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

스파이크 당단백질의 DC/L-SIGN 인식은 SARS-CoV-2 트랜스 감염을 촉진하고 글리코미메틱 길항제에 의해 억제될 수 있습니다

Research Article

Published on 2021-05-202022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, SARS, 바이오마커,

[키워드] ACE2 antigen-presenting cells authentic SARS-CoV-2 virus capture Cell cell lines cell surface CLR CLRs Concentration COVID-19 pathogenesis DC-SIGN defined described dissemination Effectiveness ENhance entry receptor envelope protein evaluated event examined Factor Final glycan glycosylation Host identify immune cells immunomodulation IMPROVE Infection inhibited innate immune response Interaction involved L-SIGN Langerin lung tissue mechanism molecular monocyte Monocytes mucosa opens pandemic Pathogens promote Protein pseudovirus receptor receptors recognize respiratory respiratory mucosa SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike protein SARS-CoV-2 virus SIGN spike spike glycoprotein Spike protein Spread T-lymphocytes target cell target cells tested the cell the SARS-CoV-2 These data trans transfer transmission rate unique Vero E6 VERO E6 cells Viral viral infection viral spike protein virus viruses while
[DOI] 10.1371/journal.ppat.1009576 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for spillback to New World rodents

사슴 쥐 사이의 SARS-CoV-2 감염, 신경병증 및 전파: 신세계 설치류로의 유출에 대한 의미

Research Article

Published on 2021-05-192022-09-10
Journal: PLoS Pathogens [Category] 진단, 치료기술,

[키워드] Amino acid amino acids animal model Asia bat BEI Resource BEI Resources blood-brain barrier Brain CD4 China coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 disease COVID-19 patients CXCL10 detectable disease elevated event Evidence expression fixation horseshoe bats Host humans IFNα IFNβ IFNγ IL-21 immune response in vivo Infection infiltration infiltration of neutrophil infiltration of neutrophils Inflammation inflammatory immune response innate immune response insert insertion intermediate host intestines Localization lung Lungs macrophages mice Mutation N-terminal domain neurological manifestation neurological manifestations Neuropathogenesis Neutrophils New World North America OAS2 occur occurred olfactory olfactory bulb oral swab oral swabs other coronaviruses pandemic passages pathology pathway Peromyscus maniculatus persistence Population predicted preponderance Pycard reservoir hosts respiratory Respiratory disease respiratory tract robust rodent SARS-CoV-2 SARS-COV-2 infection Spike protein susceptible sustained Taste TBK1 TBX21 the spike protein tongue Transmission type I upper respiratory tract Viral Viral RNA virus virus entry virus replication
[DOI] 10.1371/journal.ppat.1009585 PMC 바로가기 [Article Type] Research Article

Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells

Article

Published on 2021-05-182022-10-04
Journal: Cell Death Discovery [Category] 치료제,

[키워드] acute respiratory syndrome Antiviral Antiviral strategies approach cause caused Cell Biology cellular coronavirus Coronavirus disease 2019 COVID-19 dysregulated health emergency Huh7 cell HUH7 cells IFIT1 IFN-I IFN-I response IFN-I signaling IFN-β immunology induce inhibit inhibited innate immune response interferon interferon response interferon-stimulated gene investigation MERS-CoV Microbiology observation pathogenesis of SARS-CoV-2 Perspective Protein proteomic recent finding reduce Regulation Regulatory RIG-I SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis senescent susceptibility susceptible therapeutic strategy These cells Treatment viral infection virus
[DOI] 10.1038/s41420-021-00487-z PMC 바로가기 [Article Type] Article

Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approaches

COVID-19에 대한 잠재적 약물 표적 및 후보 약물 식별: 생물학적 네트워크 및 구조 모델링 접근법

Research Article

Published on 2021-05-172022-08-31
Journal: F1000Research [Category] MERS, 치료기술, 치료제,

[키워드] acute respiratory syndrome addition Algorithm Analysis Antigen antigen processing approach BCL3 binding affinity Biological network analysis Biomarker Biomarkers candidate drug candidate drugs CBL CEBPB complex conducted coronavirus CoV CoV infection COVID-19 CRKL cytokine demonstrated docking result drug target drug targets ERBB4 expressed expression expression profile expression profiles facilitate flexibility growth factor growth factor receptor binding HDAC9 host cell host gene host immune system human pathogen identifying immune signaling pathway include indicated inhibit innate immune response interleukin interleukin-1 KLHL12 Limma macropinocytosis MAPK MAPK signaling medicated MHC class I modulation module molecular dynamics Molecular dynamics simulation molecular dynamics simulations mortality rate MYC NCOA3 network analysis pathway Pathways peptide PPI PPI network protein-protein docking protein-protein interaction receptor Receptor binding receptor signaling reduce regulate Replication respiratory Respiratory system retrieved SARS-CoV-2 SARS-CoV-2 pathogenesis selected Severe acute respiratory syndrome Signal transduction signal transduction pathways Signaling signaling pathways Smad3 SMURF1 stability stimulatory T cell T cell receptor tyrosine VEGFA Walktrap algorithm was selected wortmannin
[DOI] 10.12688/f1000research.50850.3 PMC 바로가기 [Article Type] Research Article