intranasal – Page 23 – Communicable Diseases Research

Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice

Article

Published on 2020-09-052022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

Ad26 백신은 햄스터의 SARS-CoV-2 중증 임상 질환으로부터 보호합니다

Letter

Published on 2020-09-032022-09-12
Journal: Nature Medicine [Category] Fulltext, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 Adenovirus animals binding clinical disease clinically coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death demonstrated develop elicited expressing hamster hamsters High-dose Human immunization individual induce Infection intranasal Lower respiratory tract Mild mild illness Mortality Neutralizing antibody response neutralizing antibody responses Pathogenesis Pneumonia preclinical studies preclinical study PROTECT reduction reported respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines serotype severe acute respiratory syndrome Coronavirus severe pneumonia Spike protein subset Therapeutics These data tissues upper and lower respiratory tracts Vaccine Vaccines Viral viral replication virus replication weight loss
[DOI] 10.1038/s41591-020-1070-6 PMC 바로가기 [Article Type] Letter

Challenges to the Poultry Industry: Current Perspectives and Strategic Future After the COVID-19 Outbreak

Veterinary Science

Published on 2020-08-262022-11-01
Journal: Frontiers in Veterinary Science [Category] COVID-19,

An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

Article

Published on 2020-08-212022-10-04
Journal: Nature Communications [Category] MERS, 비임상, 임상, 치료기술,

[키워드] Adenovirus antibody Antibody Response candidate vaccine cell-mediated immune clinical evaluation CMI coronavirus SARS-CoV-2 COVID-19 vaccine dosage Effectiveness elicit Experimental models of disease expressing gene encoding generate global public health immune response Infection intramuscular Intramuscular injection intramuscularly intranasal intranasally Live attenuated vaccines macaque mice non-human primates Prophylactic Protein responses reveal rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serotype single vaccination spike Spread subsequent vaccination Vaccine viral infection Viral particles
[DOI] 10.1038/s41467-020-18077-5 PMC 바로가기 [Article Type] Article

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

Article

Published on 2020-08-192023-06-15
Journal: Cell [Category] Fulltext, MERS,

[키워드] antibody COVID-19 IgA intranasal mucosal immunity Pathogenesis protection SARS-CoV-2 T cells Vaccine
[DOI] 10.1016/j.cell.2020.08.026 PMC 바로가기 [Article Type] Article

Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase

Short Report

Published on 2020-08-182022-10-28
Journal: Virology Journal [Category] COVID-19, MERS,

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Research

Published on 2020-07-302022-10-05
Journal: Nature [Category] SARS, 변종, 유전자 메커니즘,

Efficacy of local budesonide therapy in the management of persistent hyposmia in COVID-19 patients without signs of severity: A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-07-202022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 addition alveolar association blinded breastfeeding women Budesonide cause chest CT scan close contact Control control groups Corticosteroid COVID-19 COVID-19 patient criteria CYP3A4 inhibitor disorder dissemination dysgeusia Efficacy element form France HIV hypersensitivity Hyposmia Inclusion intranasal Local Loss of Smell management MRI nasal Nasal Irrigation nodule number objective olfactory onset of symptom onset of symptoms Open-label ophthalmic Other outcome parallel group Paris participant Patient patients PCR PCR-confirmed percentage physiological saline positive serology protease protocol randomised randomised controlled trial randomization list Randomized recruited Registered rehabilitation Rothschild rotocol Sample size SARS-CoV-2 SARS-COV-2 infection severity status stratified Study protocol therapy Treatment Trial two group Version virus website
[DOI] 10.1186/s13063-020-04585-8 PMC 바로가기 [Article Type] Letter

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

530

Published on 2020-07-142022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome addition animal model antiviral drugs Characteristics China consequence consolidation convalescent serum coronavirus coronavirus disease countermeasure COVID-19 patient disease feature Ground glass opacity hamster hamsters Health human lung immunotherapies Infection inhibited intranasal isolate lesion lung lung lesion Lungs mounted naïve Neutralizing antibody response Novel coronavirus pathogenesis of SARS-CoV-2 Pneumonia Postinfection Region replicate replicated Replication replicative reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 pathogenesis serum severe lung injury Significance Spread subsequent suppressed Syrian hamsters transfer Vaccine Vaccines virus virus replication Wuhan, China
[DOI] 10.1073/pnas.2009799117 PMC 바로가기 [Article Type] 530

Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation

Review

Published on 2020-07-112022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,