Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19COVID-19에 대한 새로운 치료 목표를 식별하기 위해 공개적으로 사용 가능한 코로나 바이러스 데이터를 활용Research Article Published on 2021-09-292022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis Antiviral Asymptomatic Bioinformatic bioinformatic analysis Brain coronavirus Coronavirus-2 COVID-19 dataset disease disease susceptibility dysfunction Effects Evidence evidence of facilitate Factor Gut heart Host identify immune immune surveillance include individuals Innate immunity interferon liver long-lasting Loss of Smell lung mechanism MERS-CoV outbreak promotion question representing respiratory responsible SARS-CoV-1 SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus subversion Surveillance susceptibility therapeutic target Variability Vascular Viral viral pathogen viral replication [DOI] 10.1371/journal.pone.0257965 PMC 바로가기 [Article Type] Research Article
Rays of immunity: Role of sunshine vitamin in management of COVID-19 infection and associated comorbiditiesArticle Published on 2021-09-272023-07-02 Journal: Clinical nutrition ESPEN [Category] SARS, [키워드] COVID-19 immunology Infectious diseases interleukin-6 MERS-CoV SARS-CoV-2 Vitamin D [DOI] 10.1016/j.clnesp.2021.09.727 PMC 바로가기
Evolutionary Dynamics and Epidemiology of Endemic and Emerging Coronaviruses in Humans, Domestic Animals, and WildlifeReview Published on 2021-09-232022-10-28 Journal: Viruses [Category] COVID-19, Fulltext, SARS, 조류인플루엔자, [키워드] Rhinolopoid acute respiratory syndrome affected Alpha animals approach Arabic bat bats Beta coronaviruses canine caused coronavirus CoV CoVs cross delta variant detect Diseases Dynamics Endemic Epidemics Evolution Host Human humans infect MERS-CoV Novel coronavirus one health outbreak Pandemics Prevent prevented public health reported SARS-CoV SARS-CoV-2 Seven Still strain Surveillance susceptible Vaccine virus wild animals wildlife zoonotic [DOI] 10.3390/v13101908 PMC 바로가기 [Article Type] Review
Multi-level inhibition of coronavirus replication by chemical ER stressArticle Published on 2021-09-202022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] Analysis Antiviral antiviral effects autophagic flux block bronchial epithelial cells cell type chaperone complexes component coronavirus Coronavirus replication counteract CoV replication CoVs Degradation derivative downregulation drugs ER stress Evidence Factor HCoV-229E HERPUD1 Host human pathogen IMPROVE inducer infected cell Infection inhibit inhibiting mechanism MERS-CoV modulate pathway Pathways pharmacological Protein proteome Quality control Replication required SARS-CoV-2 selective specific treatment suppress suppresse Systems virology translational UBA6 unfolded protein response viability viral infection Virus-host interactions ZNF622 [DOI] 10.1038/s41467-021-25551-1 PMC 바로가기 [Article Type] Article
Biology and Pathogenesis of SARS-CoV-2: Understandings for Therapeutic Developments against COVID-19Review Published on 2021-09-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] alphacoronavirus Analysis animal models antiviral drugs antivirals Biology caused Characteristics Complete Coronavirus disease 2019 Coronaviruses COVID-19 development EVs extracellular vesicle FIVE Genetic HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs host-pathogen interaction host-virus interaction Human immune-evasion knowledge MERS-CoV Nidovirale Pathogenesis pathophysiology positive Research RNA virus SARS-CoV SARS-CoV-2 single-stranded the Coronaviridae the disease understanding Vaccine Vaccines virus [DOI] 10.3390/pathogens10091218 PMC 바로가기 [Article Type] Review
Potential Cross-Reactive Immunity to COVID-19 Infection in Individuals With Laboratory-Confirmed MERS-CoV Infection: A National Retrospective Cohort Study From Saudi ArabiaImmunology Published on 2021-09-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval acute respiratory syndrome adjusted age age and sex CFR Cohort Comorbidity conducted control group Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 infection Cross-immunity cross-reactive cross-reactive immune death demonstrated Evidence experiment Fatality rate finding healthcare worker higher risk Hospitalization human coronaviruses Immunity independent predictor independent variables individual individuals Infection lower risk MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus Mortality Patient Potential retrospective cohort study risk risk ratio SARS-CoV-2 SARS-COV-2 infection Saudi Arabia significantly higher starting suggested tested two group [DOI] 10.3389/fimmu.2021.727989 PMC 바로가기 [Article Type] Immunology
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronavirusesArticle Published on 2021-09-172022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] ACE2 B.1.1.7 cathepsin Cell cell line coronavirus coronavirus biology Coronaviruses CRISPR-Cas9 genome editing DPP4 entry receptor Factor generate Genetic genetic engineering genetic screen Host host gene human disease identify implicated in vivo increasingly intestinal organoid Intestinal stem cells MERS-CoV mutant Organoid Other performed potential therapeutic target protease TMPRSS2 Proteases Rapid Research reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 replication Stem-cell biotechnology target cell therapeutic interventions therapeutic target therapeutic targets TMPRSS TMPRSS2 translated variant virus replication [DOI] 10.1038/s41467-021-25729-7 PMC 바로가기 [Article Type] Article
Evolutionary Signatures Governing the Codon Usage Bias in Coronaviruses and Their Implications for Viruses Infecting Various Bat SpeciesArticle Published on 2021-09-162022-10-28 Journal: Viruses [Category] COVID-19, [키워드] ancestor appear arginine bat bats beta-CoV beta-CoVs Betacoronavirus Bia cellular Characteristics codon codon usage conserved Coronaviruses CoV CpG CpG dinucleotide demonstrated disease distribution driven by envelope gene Evolution furin cleavage site Genetic highlight Host host tissue Human infecting mammal MERS-CoV MHV-A59 microenvironment molecular murine preference reservoir SARS-CoV SARS-CoV-2 signature Specy survival synonymous Usage variety virus virus genomes [DOI] 10.3390/v13091847 PMC 바로가기 [Article Type] Article
MOV10 Helicase Interacts with Coronavirus Nucleocapsid Protein and Has Antiviral ActivityResearch Article Published on 2021-09-142022-10-29 Journal: mBio [Category] COVID-19, [키워드] activity acute respiratory syndrome Antiviral antiviral activity Antiviral effect antiviral response caused cell lines cellular cellular RNA changes in complexes conserved coronavirus CoVs CRISPR-Ca cytoplasmic decrease described Helicase help highly pathogenic highly pathogenic coronavirus highly pathogenic CoVs human CoV human CoVs humans identify immunoprecipitation in viral indicated Infection Interaction involved life-threatening MERS-CoV MERS-CoV infection metabolism Middle East modulation MOV10 mutant N protein nucleocapsid nucleocapsid protein overexpression pathogen Pathogenesis Protein required Respiratory disease respiratory syndrome coronavirus RNA SARS-CoV-2 significantly increased Structure therapeutic targets understanding Viral RNA viral RNAs virus titer Virus-host interactions viruses wild-type [DOI] 10.1128/mBio.01316-21 PMC 바로가기 [Article Type] Research Article
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5Article Published on 2021-09-072022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Activation Calu-3 cell caused CCL5 change circulating clade Contact Ex vivo experiment functional Human IFN IFNB1 IFNL1 immune gene in vitro innate immune isolate Lineage lung cell MERS-CoV Middle East nosocomial outbreak onward transmission pandemic parental phenotypic Pneumonia receptor reduced remained Replication replicative fitness respiratory syndrome coronavirus reveal Saudi Arabia sequence Signaling significantly increased South Korea spread to Strains Surveillance viral epidemiology viral evolution Viral immune evasion virus viruses [DOI] 10.1038/s41467-021-25519-1 PMC 바로가기 [Article Type] Article