Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection The COVID A to Z Randomized Clinical Trial고용량 아연 및 아스코르빈산 보충제 대 일반 관리가 SARS-CoV-2 감염이 있는 보행 환자의 증상 기간 및 감소에 미치는 영향 COVID A to Z 무작위 임상 시험Randomized Controlled Trial Published on 2021-02-122022-08-13 Journal: JAMA Network Open [Category] MERS, 임상, [키워드] acid acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse effect adverse effects age ambulatory ambulatory patient ambulatory patients ascorbic acid benefit Care Chain Reaction clinical clinical trial Combination conditional power conducted coronavirus cough COVID cumulative deaths decrease diagnosed diagnosis of SARS-CoV-2 duration of symptom early treatment Effect end point enrolled Evidence fatigue Fever finding group groups health system High-dose hospitalizations Identifier Importance Infection Length mitigate multicenter no significant difference not affect objective Open-label open-label trial participant Patient Point polymerase chain polymerase chain reaction prescribed medications primary end point progression Randomized randomized clinical trial receive receiving reduce reduction in Registration Relevance required respiratory Result SARS-CoV-2 SARS-COV-2 infection secondary secondary outcome Secondary outcomes setting severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Shortness of breath significant difference significantly Standard of care Symptom symptom severity score Symptoms Treatment treatment groups Trial Trial registration usual care women Zinc zinc gluconate [DOI] 10.1001/jamanetworkopen.2021.0369 PMC 바로가기 [Article Type] Randomized Controlled Trial
A double blinded placebo controlled comparative clinical trial to evaluate the effectiveness of Siddha medicines, Kaba Sura Kudineer (KSK) & Nilavembu Kudineer (NVK) along with standard Allopathy treatment in the management of symptomatic COVID 19 patients – a structured summary of a study protocol for a randomized controlled trial증상이 있는 COVID 19 환자의 관리에서 표준 동종 요법 치료와 함께 Siddha 의약품, Kaba Sura Kudineer(KSK) 및 Nilavembu Kudineer(NVK)의 효과를 평가하기 위한 이중 맹검 위약 대조 비교 임상 시험 - 에 대한 연구 프로토콜의 구조화된 요약 무작위 대조 시험Letter Published on 2021-02-112022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] acute respiratory distress syndrome addition Adverse adverse events age age and sex appearance Arm Asymptomatic Bacterial biochemical markers blinded block calculated CAM change Chemical clinical clinical symptom Clinical symptoms clinical trial Complication complications Controlled count COVID COVID 19 COVID 19 patient CRP Ct value CTRI D-dimer Data analysis Date determine diagnose dimer dissemination drug Effect Effectiveness element eligibility eliminated enrolment evaluate exploratory ferritin food GMP group Herbal Hospital stay IL 6 IL6 incidence India Infection infiltration Inflammatory marker inflammatory markers Informed consent investigators involved Laboratory LDH literature management marker Medical Sciences Medicine Medicines Microsoft Excel moderate symptom moderate symptoms morning Night number objective outcome participant Patient patients PCR Placebo Pneumonia profile protocol randomised controlled trial randomization Randomized Randomized controlled trial Ratio recruited recruitment reduce reduction Registered Registration registry reported respiratory respiratory distress Respiratory distress syndrome risk Sample Sample size SARS-CoV-2 secondary Secondary objectives Secondary outcomes severe COVID-19 symptoms Siddha Siddha Medicine smoking SPIRIT guidelines statistician status Study protocol submission Sura symptomatic Taste tea the disease time Total Treatment Trial trial protocol Trial registration value Viral Viral load Viral pneumonia website were blinded [DOI] 10.1186/s13063-021-05041-x PMC 바로가기 [Article Type] Letter
Safety and feasibility of using acellular sterile filtered amniotic fluid as a treatment for patients with COVID-19: protocol for a randomised, double-blinded, placebo-controlled clinical trialCOVID-19 환자를 위한 치료법으로 무균 무균 여과 양수 사용의 안전성 및 타당성: 무작위 배정, 이중 맹검, 위약 대조 임상 시험 프로토콜Article Published on 2021-02-112022-09-11 Journal: BMJ Open [Category] 임상, [키워드] administration amniotic Amniotic fluid approved Biomarker C-reactive protein cellular clinical trial clinical trials clinically collected conditions COVID-19 Critical Critical care determine double-blinded drug Drug administration Ethics experimental models FDA feasibility filtered food hospital Hospitalised patients Human include Inflammation Inflammatory Inflammatory response institutional review board Intensive intensive & intensive care intravenous laboratory-confirmed Laboratory-confirmed COVID-19 life methodology Mortality New outcome Patient patients with COVID-19 peer-reviewed pilot study Placebo placebo-controlled clinical trial Primary outcome protocol randomised recruited reduce Registered registration number respiratory respiratory medicine (see thoracic medicine) Result Safety secondary Secondary outcomes shown Therapeutic treatment Thoracic tissue tissue injury Treatment Trial university US FDA US Food and Drug Administration Utah ventilator-free day Ventilator-free days [DOI] 10.1136/bmjopen-2020-045162 PMC 바로가기 [Article Type] Article
Transitional care from skilled nursing facilities to home: study protocol for a stepped wedge cluster randomized trial전문 간호 시설에서 가정으로의 전환 치료: 단계적 쐐기 군집 무작위 시험을 위한 연구 프로토콜Study Protocol Published on 2021-02-052022-09-10 Journal: Trials [Category] MERS, 임상, 치료기술, 치료제, [키워드] aging assigned Care Caregivers chronic conditions Cluster Complete complex contribute COVID-19 pandemic dependent on detect determine discharge discharge planning discharged distress Efficacy frailty functional Functional status home home care illness illnesses IMPROVE include increase in interval Intervention life linear mixed model mitigate modifications Mortality North observation observations occurred outcome Palliative care Patient Patient discharge patient’s home patients plan Prevent Primary outcome Primary outcomes protocol Quality of life randomized trial Randomly receive risk secondary Secondary outcomes significance level Skilled nursing facilities skilled nursing facility Study protocol trajectory transition Transitional care Trial Trial registration two-sided USA usual care while [DOI] 10.1186/s13063-021-05068-0 PMC 바로가기 [Article Type] Study Protocol
Retinal capillary involvement in early post-COVID-19 patients: a healthy controlled studyObservational Study Published on 2021-02-012022-10-04 Journal: Graefe's Archive for Clinical and Experimental Oph [Category] MERS, SARS, 임상, [키워드] addition clinical condition Cohort COVID-19 endothelial evaluated feature groups hallmark healthy healthy control healthy volunteer hemorrhage hospital discharge Macula membrane Mild no significant difference OCT angiography organ damage outcome Patient patients patients with COVID-19 perimacular post-COVID-19 patient Prevalence reported Result Retina Retinal Retinal vascular layers SARS-CoV-2 SARS-COV-2 infection Secondary outcomes Severe case significant difference subjects systemic two groups Vascular vessel visual acuity vitreous worsening [DOI] 10.1007/s00417-020-05070-3 PMC 바로가기 [Article Type] Observational Study
Systematic review and meta-analysis of effectiveness of treatment options against SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 치료 옵션의 효과에 대한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-02-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료제, [키워드] 95% confidence interval acute respiratory syndrome Adverse adverse events all-cause mortality calculated clinical trials Coronavirus-2 COVID-19 discharge Effectiveness Efficacy and safety event HCQ Hydroxychloroquine Intervention intervention arm mechanical ventilation Meta-analysis no difference Odds ratio Odds ratios outcome Patient performed Pooled rates Primary outcome profiles progression randomized clinical trial respiratory SARS-CoV-2 SARS-COV-2 infection secondary outcome Secondary outcomes Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severe disease significantly higher systematic review therapeutic intervention therapeutic interventions therapeutic options Treatment Viral viral clearance [DOI] 10.1002/jmv.26302 PMC 바로가기 [Article Type] Meta-Analysis
Tocilizumab for the treatment of adult patients with severe COVID-19 pneumonia: A single-center cohort study중증 COVID-19 폐렴 성인 환자의 치료를 위한 Tocilizumab: 단일 센터 코호트 연구Article Published on 2021-02-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료제, [키워드] 6-point ordinal scale 95% confidence interval adjusted odds ratio adverse events all-cause mortality analyzed Body body temperature C-reactive protein cardiac rate cardiac rates clinical Clinical improvement clinical status cohort study consecutive patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia cytokine release decrease dose dropped Evidence hospital discharge hyperinflammatory phase immunomodulation immunomodulatory therapy interferon intravenous Laboratory Lactate lactate dehydrogenase lead lymphocyte Lymphocyte count monoclonal antibody Mortality Ordinal Scale outcome oxygen oxygen saturation Patient Pneumonia Primary outcome pulse oximetry Rate receptor respiratory Safe SARS-CoV-2 secondary Secondary outcomes serum lactate severe COVID-19 Severe COVID-19 pneumonia significantly single-center single-center study TCZ temperature Tocilizumab Treatment vital sign vital signs with COVID-19 [DOI] 10.1002/jmv.26308 PMC 바로가기 [Article Type] Article
COVID-19 aerosol box as protection from droplet and aerosol contaminations in healthcare workers performing airway intubation: a randomised cross-over simulation study기도 삽관을 수행하는 의료 종사자의 비말 및 에어로졸 오염으로부터 보호하는 COVID-19 에어로졸 상자: 무작위 교차 시뮬레이션 연구Randomized Controlled Trial Published on 2021-02-012022-08-31 Journal: Emergency medicine journal : EMJ [Category] MERS, 임상, 치료제, [키워드] addition aerosol Aerosol box airway assistant body regions concern conducted Contamination COVID-19 cross-over Diseases doffing Efficacy Emergency emergency department emergency medicine exposure to Germ healthcare worker Healthcare workers Infectious diseases Innovation intubating intubation median Medicine no significant difference offset operator outcome participant patients with COVID-19 performed Personal protective equipment PPE Primary outcome PROTECT random randomised reduce reduced Region reported risk SARS SARS-CoV-2 secondary Secondary outcomes significantly significantly higher Transmission university Usage visibility [DOI] 10.1136/emermed-2020-210514 PMC 바로가기 [Article Type] Randomized Controlled Trial
Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews임신 중 COVID-19의 모성 및 신생아 특성 및 결과: 체계적인 검토 개요Review Published on 2021-01-122022-09-12 Journal: International Journal of Environmental Research an [Category] Coronavirus, 진단, [키워드] abortion Analysis analyzed Anxiety can not cesarean sections conducted contributed COVID-19 COVID-19 pandemic database excluded fetal fetal infection heterogeneity iatrogenic ICU admission ICU admission rate Increased Infection involved labor Maternal Maternal mortality rate Maternal outcomes mechanical ventilation membrane membranes mode moderate mortality rate mortality rates mother Neonatal Neonate Neonates Newborn outcome PCR positivity populations Pregnancy pregnant women Premature Preterm birth preterm deliveries preterm delivery preterm labor Primary outcome Primary outcomes Probability PROSPERO protocol Quality raise ranged Registered remained Result review rupture rupture of membranes SARS-CoV-2 searched Secondary outcomes Stillbirth symptomatic systematic reviews Transmission vertical transmission was performed women [DOI] 10.3390/ijerph18020596 PMC 바로가기 [Article Type] Review
Effectiveness and cost-effectiveness of four different strategies for SARS-CoV-2 surveillance in the general population (CoV-Surv Study): a structured summary of a study protocol for a cluster-randomised, two-factorial controlled trial일반 인구에서 SARS-CoV-2 감시를 위한 4가지 다른 전략의 효과 및 비용 효율성(CoV-Surv 연구): 클러스터 무작위 2인자 통제 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-082022-09-01 Journal: Trials [Category] MERS, 임상, 진단, 치료기술, 치료제, [키워드] acceptability Active surveillance activities activity addition Admission age analyzed applicability applied approach Arm ARMS Asymptomatic Asymptomatic carrier Asymptomatic carriers Asymptomatic case Asymptomatic cases best Blinding caused choice clinical clinical symptom Clinical symptoms close contact Cluster cluster-randomised controlled trial Complete completion component conducted Controlled trial Cost effectiveness cost-effectiveness Course COVID-19 defined detection rate determine determined by diagnosed Diagnosis dialectic Disease surveillance dissemination effective Effectiveness element eligible estimate estimates evaluated expected False positives finding followed by Gender General population generate Germany gold gold standard Health healthy hospital household identify implementation include individual individuals infected individual infected individuals Infection information isothermal amplification Laboratory limit Local local public health lockdowns Loop-mediated isothermal amplification mail men and women MONITOR municipality objective Older outbreak outcome pandemic parameter parameters participant Perception Perspective population surveillance population-based surveillance positive positive sample PPS Precision predict preference preferences Prevalence Prevent Primary outcomes Probability prognostic model protocol qPCR Quantitative questionnaire random Random sample randomisation Randomly real time receive Region Registered rejection representing required response rates resulting risk RT-LAMP Saliva saliva samples Sample Sample size sample sizes SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 surveillance SARS-CoV-2 testing SARS-CoV-2 tests Satisfaction screened second secondary Secondary outcomes selected Sensitivity and specificity Spread status Strategy study participant Study participants study participation Study protocol Surveillance Symptom symptomatic test result tested the SARS-CoV-2 threshold Total total sample size Trial Trial registration variety virus website while [DOI] 10.1186/s13063-020-04982-z PMC 바로가기 [Article Type] Letter