Lactoferrin as Immune-Enhancement Strategy for SARS-CoV-2 Infection in Alzheimer’s Disease PatientsReview Published on 2022-04-252023-07-09 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Alzheimer’s disease brain-immunity interactions COVID-19 Dementia Inflammation lactoferrin Saliva SARS-CoV2 [DOI] 10.3389/fimmu.2022.878201 PMC 바로가기 [Article Type] Review
SARS-CoV2 wild type and mutant specific humoral and T cell immunity is superior after vaccination than after natural infectionSARS-CoV2 야생형 및 돌연변이 특이 체액성 및 T 세포 면역은 자연 감염 후보다 백신 접종 후 우수Article Published on 2022-04-252022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding Alpha antibodies antibody Antibody titer Antibody titers B.1.617.2 Blood blood sample Blood samples CD4 CD4+ T cell cytokine production delta variant Finger prick flow cytometric flow cytometric intracellular cytokine staining humoral IFN-γ IL-2 immune response immune responses Immunity Infection intracellular cytokine staining investigated mutant natural infection neutralisation no significant difference overcome pandemic Patient peptide peptides positive RBD RBD binding Receptor binding domain reduced response responses SARS-CoV2 significant difference significantly Specific Spike protein Stimulation strain Strong subject subjects T cell T cell response T cell responses tested the vaccine TNF-α vaccinated individuals vaccination variant variants Virus neutralization was reduced were measured wild type [DOI] 10.1371/journal.pone.0266701 PMC 바로가기 [Article Type] Article
Antiviral activity of ciclesonide acetal derivatives blocking SARS-CoV-2 RNA replicationShort Communication Published on 2022-04-182023-07-02 Journal: Journal of pharmacological sciences [Category] COVID19(2023년), SARS, [키워드] antiviral activity Ciclesonide SARS-CoV2 [DOI] 10.1016/j.jphs.2022.04.001 PMC 바로가기 [Article Type] Short Communication
Bees can be trained to identify SARS-CoV-2 infected samples꿀벌은 SARS-CoV-2 감염 샘플을 식별하도록 훈련될 수 있습니다.Article Published on 2022-04-152022-09-11 Journal: Biology open [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy addition animals bee bees changes in Community conditioned Conditioning COVID-19 COVID-19 pandemic detectable detection diagnostic diagnostic sensitivity diagnostic test diagnostics Efficacy evaluate experiments Health status Honeybees Human identify Infrastructure lack memory Neovison Non-invasive offer Olfaction organic compound Pathologies predict protocol protocols provide provided Rapid test required resource respond SARS-CoV-2 SARS-CoV2 sensitivity specificity subject tested Trial viral disease Viral diseases VoC zoonotic [DOI] 10.1242/bio.059111 PMC 바로가기 [Article Type] Article
Role of serology tests in COVID-19 non-hospitalized patients: A cross-sectional studyCOVID-19 입원하지 않은 환자에서 혈청 검사의 역할: 단면 연구Article Published on 2022-04-142022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Analysis antibody Antibody titer Assessing association Asymptomatic can be used catastrophic characteristics of patient chills chronic disease clinical conducted Contact coronavirus cough Course COVID-19 COVID-19 patient cross-sectional disease Dyspnea epidemiological fatigue feature Fever GI symptom IgG IgG and IgM IgG level IgG test IgM IgM and IgG IgM test Infection investigated Iran Mild myalgia Nasopharyngeal swab Outpatient p value Patient patients PCR PCRs positive positive PCR positive PCR test role SARS-CoV-2 SARS-CoV2 serologic test serology serology test significantly specimen Symptom Tehran tested underlying disease [DOI] 10.1371/journal.pone.0266923 PMC 바로가기 [Article Type] Article
High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease SeverityCOVID-19 환자에서 낮은 친화도 항체의 높은 역가는 질병 중증도와 관련이 있습니다Article Published on 2022-04-132022-09-12 Journal: Frontiers in Immunology [Category] Coronavirus, COVID19(2023년), SARS, 진단, [키워드] addition Affect affinity analyzed antibodies antibody production Antibody Response Antibody titer Antigen association binding clinical information coronavirus disease COVID COVID-19 COVID-19 patient Critically ill critically ill patients disease Disease progression disease severity domain epitope mapping humoral IgA IgA antibody IgG IgG antibody titer IgM immunoassay Infectious diseases Interaction investigated isotype material maturation pandemic Patient peptide positive Prognostic marker Protein Proteins RBD SARS-CoV2 sera severity specific antibody SPRi (surface plasmon resonance imagery) the RBD titer viral infection [DOI] 10.3389/fimmu.2022.867716 PMC 바로가기 [Article Type] Article
Characterization, in-silico, and in-vitro study of a new steroid derivative from Ophiocoma dentata as a potential treatment for COVID-19 Research Published on 2022-04-072022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료법, 치료제, [키워드] Anti-inflammatory anti-inflammatory activity anti-inflammatory properties antiviral drug characterization component computer Concentration conducted COVID-19 curative demonstrated Efficacy evaluate exhibited fibroblast cells IC50 in-silico In-vitro inhibitor invertebrate investigation molecular docking plaque Potential treatment Red reduction SARS-CoV2 Standard Toxicity Virtual screening [DOI] 10.1038/s41598-022-09809-2 [Article Type] Research
Identification of Entry Inhibitors against Delta and Omicron Variants of SARS-CoV-2SARS-CoV-2의 Delta 및 Omicron 변이체에 대한 진입 억제제 식별Article Published on 2022-04-062022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approved authentic SARS-CoV-2 virus Beta block Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta Delta variants dolutegravir domain dominant drug drug library EC50 value EC50 values Entry inhibitor entry inhibitors Etravirine identification Infection inhibited inhibitor inhibitors molecular docking molecular interaction neutralization test neutralizing activities Neutralizing activity omicron outbreak plaque reduction neutralization Plaque reduction neutralization test pseudovirus pseudovirus entry pseudoviruses RBD RBD domain receptor Receptor-binding domain residue robust SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 severe acute respiratory syndrome Coronavirus significantly Spike protein Spike proteins the RBD the receptor-binding domain These data variants Vero E6 Vero E6 cell VERO E6 cells viral entry viral spike protein viral variant was used [DOI] 10.3390/ijms23074050 PMC 바로가기 [Article Type] Article
Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung OrganoidshiPSC에서 파생된 폐 오르가노이드에서 SARS-CoV-2에 대한 두 가지 다른 치료 접근 방식Article Published on 2022-04-052022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] ACE2 airways alveolar approach approaches AT2 candidate Cell complex COVID-19 COVID-19 treatment develop dipeptidyl peptidase Dipeptidyl peptidase-4 distal DPP4 drugs Efficacy Efficiency evaluate Evidence Express expression of gene health emergency hiPSCs hLORGs homologous host cells human cells implicated in vitro in vivo Infection Inflammatory response Innate immunity lung modulation monoclonal Neutralizing neutralizing antibody neutralizing monoclonal antibody organ Organoid peptide pluripotent stem cell Protein proximal pseudovirus receptor receptors reducing reduction SARS-CoV-2 SARS-CoV-2 S SARS-CoV2 SARS-CoV2 pseudovirus spike Spike protein stem cells Structure synthetic peptide tested tetravalent therapeutic These data treated Treatment variant Viral viral entry were infected [DOI] 10.3390/cells11071235 PMC 바로가기 [Article Type] Article
Pulmonary Embolism (PE) Prevalence in Mexican-Mestizo Patients With Severe SARS-COV-2 (COVID-19) Pneumonia At A Tertiary-Level Hospital: A ReviewReview article Published on 2022-04-012022-10-05 Journal: Current problems in cardiology [Category] 바이오마커, [키워드] addition Analysis Biomarker calculated Cancer Chest Chronic kidney disease Comorbidity COVID-19 criteria Descriptive statistics Diagnosis disease Embolism events groups hypercoagulable Infarction Myocardial obesity Patient patients with SARS performed peripheral arterial thrombosis Pneumonia Prevalence prevalence rate prognostic biomarker pulmonary reported review SARS-CoV2 severe pneumonia student subsegmental systemic arterial hypertension the patient Thromboembolism thrombotic complication treated Type Vascular venous thromboembolic was performed Wilcoxon test Wuhan, China [DOI] 10.1016/j.cpcardiol.2022.101208 [Article Type] Review article