Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics장기 실패, 항 바이러스 치료 및 인구 통계 학적 특성에 중점을 둔 급성 코비드 -19 감염에서 면역 혈청 마커의 시간적 변화에 대한 편견없는 분석Immunology Published on 2021-06-112022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] 48 hour 48 hours Admission age analyzed Biomarker Biomarkers CCL23 CD28 change chemokine chemokines collected condition convalescent plasma correlated Course COVID-19 COVID-19 admission Deceased decorin demographic demographics demonstrated elevated failure GzmB heterogeneity Hydroxychloroquine ICU identification IL-15 IL-18 immune immunological increased expression individual kidney Kidney failure lack LAG3 LAMP3 ligands Longitudinal studies MCP MCP-1 MCP-3 monocyte Mortality Older age pathology pleiotrophin positively correlated programmed death Protein proteomics remdesavir Remdesivir respiratory serum serum levels Serum Marker Seven severity of COVID-19 steroid Steroids target Temporal the disease therapeutic TNFRSF21 Variation VEGF with COVID-19 [DOI] 10.3389/fimmu.2021.650465 PMC 바로가기 [Article Type] Immunology
Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection지속적인 SARS-CoV-2 감염이 있는 COVID-19 환자의 임상 및 분자 특성Article Published on 2021-06-092022-09-12 Journal: Nature Communications [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] activated Antimicrobial responses CD14 Cell Characteristics chemokines clinical correlation COVID-19 patient COVID-19 patients cytokine Cytokines described expression Genes healthy donor healthy donors immune characteristics Immune suppression Immunosuppression independent Infection interleukin LDs less lymphotoxin molecular molecular feature monocyte Monocytes natural killer Necrosis NK cell Pathways Patient patients patients with COVID-19 persistence persistent infection reduced Regulatory T cell regulatory T cells ribosomal protein RNA sequencing SARS-COV-2 infection short duration Single-cell RNA sequencing Systems analysis T cells TNF Tumor tumor necrosis tumor necrosis factor viral infection viral shedding [DOI] 10.1038/s41467-021-23621-y PMC 바로가기 [Article Type] Article
Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19Article Published on 2021-06-082022-10-04 Journal: Cell Discovery [Category] 바이오마커, 변종, 진단, 치료제, [키워드] addition alveolar epithelial cells Alveolar macrophages Analysis blood cell bronchoalveolar cause Cell signalling characterized conditions coronavirus disease Course COVID-19 cytokine diagnostics Disease progression elevated events Factor gene regulatory network host response host responses immunology indicate Integrative analysis Laboratory test Laboratory tests lung lymphocytopenia microenvironment monocyte organ pathophysiology Patient Peripheral blood proteomes proteomic proteomics provide Shanghai systemic immune response therapy Transcriptome transcriptomic [DOI] 10.1038/s41421-021-00274-1 PMC 바로가기 [Article Type] Article
lncRNA-HEIM Facilitated Liver Fibrosis by Up-Regulating TGF- β Expression in Long-Term Outcome of Chronic Hepatitis BOriginal Research Published on 2021-06-082023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] chronic hepatitis B virus (HBV) Liver fibrosis lncRNA long-term antiviral treatment monocyte transforming growth factor β (TGF-β) [DOI] 10.3389/fimmu.2021.666370 PMC 바로가기 [Article Type] Original Research
Investigation of Coagulation Biomarkers to Assess Clinical Deterioration in SARS-CoV-2 InfectionMedicine Published on 2021-06-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Activation Admission association Biomarker caused clinical Clinical outcome clinically Coagulation Cohort country COVID-19 COVID-19 progression death deregulation exploratory fibrinogen fibrinogen level Final Hemostasis hypercoagulability ICU ICU admission increased risk infected patient intensive care investigation Logistic regression analysis monocyte Mortality New coronavirus pandemic Patient patients SARS-CoV-2 spread to steroid threshold thrombin Thrombin generation worsening [DOI] 10.3389/fmed.2021.670694 PMC 바로가기 [Article Type] Medicine
Characteristics of the pediatric patients diagnosed with SARS-CoV-2 infection in a Romanian children’s hospital: a retrospective studyEpidemiology Published on 2021-06-042022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Admission age All the patient analyzed Asymptomatic Characteristics children Clinical and epidemiological characteristics Clinical data co-morbidity Comorbidities conducted cough COVID-19 COVID-19 pandemic diagnosed digestive disease distribution Emergency epidemiological evaluated female Gender hematological high risk highlight ICU IMPROVE information Laboratory and radiological characteristics leukocytes male Mild moderate disease monocyte Patient patients Pediatric patient physician Pyrexia required Result retrospective Retrospective study Romania SARS-COV-2 infection significant difference Symptom symptomatic symptomatic and asymptomatic symptomatic and asymptomatic patients Symptomatic patients Symptoms the disease the patient was performed X-ray [DOI] 10.7717/peerj.11560 PMC 바로가기 [Article Type] Epidemiology
Cytokine Overproduction and Immune System Dysregulation in alloHSCT and COVID-19 PatientsImmunology Published on 2021-06-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptive affected age Allogeneic alloHSCT immunology analyzed approach Cell co-morbidities collected data Comorbidities Course COVID-19 COVID-19 immunology COVID-19 patient COVID-19 patients cytokine cytokine overproduction cytokine production Cytokine release syndrome Cytopathic effect damaged DAMP Deleterious deteriorate disease event expression facilitated Factor Genes Genetic hallmark highlighting HLADR homeostasis Host immune system Immunity immunogenetic profiling Increases Inflammatory cytokines inflammatory process Interaction intracellular signaling Invasion laboratory data Malnutrition modify molecular monocyte monocytic-marrow derived suppressor cells over-production of cytokine overproduction pathogenicity pathway Patient patients pro-inflammatory cytokines receptors regimen released respond sequence severity Signal transduction similarity spreads stimulate System TCR beta repertoire tissue Transcription turn vicious cycle virus virus infection [DOI] 10.3389/fimmu.2021.658896 PMC 바로가기 [Article Type] Immunology
Clinical Characteristics and Survival Analysis in Frequent Alcohol Consumers With COVID-19Nutrition Published on 2021-06-022022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] acute respiratory syndrome addition Adults age alcohol anti-bacterial Anti-viral C-reactive protein clinical Cohort consumer Consumption coronavirus Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19-associated inflammation CRP death death rate demonstrated disease Disease progression females generate Health immune response immune responses increase in Infection infections Inflammation investigated lymphocyte male marker men mitigate monocyte neutrophil count Neutrophil-to-lymphocyte ratio no difference outcomes Patient patients with COVID-19 presenting reduction in Risk factors SARS-CoV-2 smoking syndrome women [DOI] 10.3389/fnut.2021.689296 PMC 바로가기 [Article Type] Nutrition
Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19말초 면역 세포의 단일 세포 후성유전체 환경은 COVID-19에서 회복 중인 개인의 훈련된 면역 확립을 보여줍니다Article Published on 2021-06-012022-09-11 Journal: Nature cell biology [Category] SARS, 유전자 메커니즘, 임상, 치료기술, 치료법, [키워드] accelerated activated acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Analysis antibody asymptomatic infection B cell B-cell cause CD14 CD16 CD8 chromatin collected coronavirus coronavirus 2 COVID-19 death developmental differentiation epigenomic exhibited expansion healthy donors highlighting immature Immune cell immune cells immune response immune responses Immunity Immunological memory individual individuals Infection IRF1 Lineage Memory cells monocyte Monocytes mononuclear cell performed Peripheral blood Peripheral blood mononuclear cells Plasma cells profile promote reported reveal SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe complication severe complications single-cell T cell T cells [DOI] 10.1038/s41556-021-00690-1 PMC 바로가기 [Article Type] Article
Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients중증 COVID-19 환자에서 활성화된 단핵구 소비로 B 세포 활성 증가Clinical Trial Published on 2021-06-012022-09-12 Journal: European Journal of Immunology [Category] MERS, SARS, 임상, 진단, [키워드] activated Analysis Autoimmune Autoimmunity ⋅ B/T-cell ratio ⋅ COVID-19 ⋅ Lymphocytes ⋅ Monocytes. B-cell Care CD4 CD8 Cell cellular Cohort cohorts Complication controls COVID-19 death died elevated Frequency ICU IgG1 IgG3 immune changes Immune status Increased Infection intensive care Lymphocytes monocyte Monocytes NK cells over parameter Pathogenesis Patient patients treated patients with COVID-19 performed Population reduced SARS-CoV2 severe COVID-19 severe COVID-19 patient significant difference significantly higher significantly lower Survivors T-lymphocytes treated triggered [DOI] 10.1002/eji.202049163 PMC 바로가기 [Article Type] Clinical Trial