mononuclear cell – Page 24 – Communicable Diseases Research

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing

Article

Published on 2020-05-042022-10-31
Journal: Cell Discovery [Category] COVID-19,

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

코로나19 환자에서 기관지폐포세척액과 말초혈액 단핵세포의 전사적 특성

Article

Published on 2020-03-312022-09-06
Journal: Emerging Microbes & Infections [Category] Communicable Disease, COVID-19, MERS, SARS,

[키워드] Activation Anti-inflammatory Apoptosis association BALF Bronchoalveolar lavage fluid carried caused CCL2 CCL2/MCP-1 CCL3 CCL3/MIP-1A CCL4 CCL4/MIP1B Characteristics China country COVID-19 COVID-19 outbreak COVID-19 pathogenesis COVID-19 patient COVID-19 patients CXCL10 CXCL10/IP-10 cytokine cytokine release effort fatal disease Guidance HCoV highlight Host Host immune response host inflammatory response host response identify Infection Inflammation Inflammatory cytokine inflammatory cytokine profile IP-10 lymphocyte Lymphocytes lymphopenia medication molecular mononuclear cell mononuclear cells Mortality P53 signalling pathway Pathogenesis patients PBMC Peripheral blood Peripheral blood mononuclear cells public health RNA RNAs SARS-CoV-2 SARS-COV-2 infection Sequencing specimen therapeutic drug transcriptional Transcriptome transcriptome dataset transcriptome profiling transcriptome sequencing Treatment valuable resource
[DOI] 10.1080/22221751.2020.1747363 PMC 바로가기 [Article Type] Article

Analysis of Swine Conventional Dendritic Cells, DEC205 + CD172a +/− CADM1 + , from Blood and Spleen in Response to PRRSV and PEDV

Article

Published on 2019-10-312022-10-28
Journal: Viruses [Category] Coronavirus, MERS,

A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virus

Research Article

Published on 2018-09-142022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS,

Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens

Research Article

Published on 2016-07-132022-10-28
Journal: Veterinary Research [Category] Coronavirus, MERS,

Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다

Research Article

Published on 2013-05-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated After allele Analysis approved drug Arthritis association Author B cells B lymphocyte B lymphocytes Biology can be used CD19+ CD40 CD40 ligand CD40 signaling Cell cell line chemical compounds clinical care coding Combination complex Compound consequence controls correlation counter deep sequencing develop disease drug Drug discovery drugs effort eQTL ExoN exonic explain expression finding Follow-up gain-of-function Genetic genetic findings Genome-wide association studies Genome-wide association study genotyping guide GWAS healthy control homozygous Human Human genetics identify implicated increase individuals Infection Inflammation inhibit inhibitor loci locus lymphocyte Lymphocytes mononuclear cell mononuclear cells mouse NF-kB NF-κB NF-κB signaling non-risk allele observé p65 pathway Patient Peripheral blood Peripheral blood mononuclear cells Phosphorylation Protein Quantitative RA RELA reporter retroviral Rheumatoid rheumatoid arthritis risk risk allele Screen second Sequencing seropositive Signaling single SNP small molecule Small molecules small-molecule screen subject subunit therapy trait traits transcription factor treat variant while
[DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다

Research Article

Published on 2013-04-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer
[DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

MicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다

Research Article

Published on 2013-02-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 3′ UTR 3′UTR activate affecting African Americans allelic Americans Antigen Asian Asians association Author Autoimmune Autoimmune disease binding binding site C allele C-allele carriers conducted contributed Control copy number correlated debilitating autoimmune disease decrease Degradation dose-dependent downregulated driven by duplication elevated Epigenetic European Evidence exhibited exhibiting expression functional G allele G-allele genomic greater HEK-293 HEK-293 cell HEK-293 cells Human identify IFN IFN-α pathway increased risk independent individual innate immune activation lack led to luciferase luciferase activity Lupus lupus erythematosus lupus-like disease mechanism microRNA microRNA-3148 microRNA–gene miR-3148 modulation mononuclear cell mononuclear cells mRNA murine model non-risk allele non-risk C allele nuclear nucleotide Odds ratio overexpression Pathways PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells polymorphism predicted promote Protein protein level provide R 2 reduction regulate Regulatory reported reporter reporter gene respond resulting risk sequence signaling pathways significantly increased single nucleotide Single nucleotide polymorphism SLE SLE patient SLE patients SNP subject susceptibility systemic systemic lupus erythematosus the strongest These data TLR7 TLR7 gene TLR7 mRNA TLR7-TLR8 region TLR7/8/9 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors transcript transcript level transcripts transfected cells type I interferon UTR variant Variation while
[DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article

A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria

A −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West
[DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article

Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS

Research

Published on 2005-05-112022-10-28
Journal: Respiratory Research [Category] Coronavirus,

[키워드] abnormality acute phase acute respiratory syndrome alveolar cell alveolar macrophage Alveolar macrophages BALF Bronchoalveolar lavage Bronchoalveolar lavage fluid CD4/CD8 CD8 cell count cells clearance compared Computed tomography controls coronavirus correlated Course cytokine Cytokines described desquamation detected determine dysregulation Factor Fever High-resolution High-resolution CT HRCT hyaline membrane formation IL-6 IL-8 independent infiltration Inflammatory investigated lung Lung inflammation MCP-1 Microscopy mononuclear cell non-randomized occur Particle Patient patients persistence persistent Plasma cytokine profiles RANTES Resolution Result Retrospective analysis SARS SARS patient significantly subpopulations T lymphocyte T-cell therapy TNF-α
[DOI] 10.1186/1465-9921-6-42 PMC 바로가기 [Article Type] Research