Large-scale sequencing of SARS-CoV-2 genomes from one region allows detailed epidemiology and enables local outbreak management한 지역에서 SARS-CoV-2 게놈의 대규모 시퀀싱을 통해 자세한 역학이 가능하고 지역 발병 관리가 가능합니다.Research Articles Published on 2021-06-292022-09-10 Journal: Microbial Genomics [Category] MERS, SARS, 치료기술, [키워드] activities activity analyses ARTIC assist Care clinical sample COG-UK collected Community community organizations COVID-19 COVID-19 pandemic D614G effort Epidemiology Evidence evidence of Evolution expansion Genetic variation Genome genome sequence Genome sequences Genome sequencing Genomic epidemiology Genomics Health help hidden hospital hospitals identify infection control initial Lineage lineages Local Longitudinal data longitudinal samples low-density management measure Metadata Mutation National NGS no evidence of nosocomial organization outbreak pandemic patients Phylogenetic positive positive sample progressed provided public health Reinfection reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes Sequencing sequencing data SNPs Spike protein Spread the SARS-CoV-2 genome Transmissibility Transmission virus whole genome Whole genome sequencing [DOI] 10.1099/mgen.0.000589 PMC 바로가기 [Article Type] Research Articles
Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide Monitoring전세계 6 개월의 전세계 모니터링을 통한 관련 SARS-COV-2 게놈 변이Research Article Published on 2021-06-292022-09-10 Journal: BioMed Research International [Category] 변종, 진단, [키워드] Analysis analyzed Antiviral treatment Asia changed Cluster Clustering analysis D614G diagnostic event Evolution of SARS-CoV-2 False-positive Frequency Genome Genome sequencing geographical location GISAID database hotspot information monitoring Month Mutation nonsynonymous mutation Nsp12 NSP2 occurred Oceania ORF3a outbreak pandemic provide Q57H reference genome SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes the SARS-CoV-2 transition transition mutations Vaccination strategies variant Variation was used [DOI] 10.1155/2021/5553173 PMC 바로가기 [Article Type] Research Article
The architecture of the SARS-CoV-2 RNA genome inside virionArticle Published on 2021-06-242022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] contribute COVID-19 pandemic D614G develop facilitate forms genome structure Interaction investigated junctions knowledge Mutation pathogen predict provide RNA RNA genome RNA viruses SARS-CoV-2 secondary Sequencing sequencing method sequencing technology single-stranded SRAS-CoV-2 Structure the SARS-CoV-2 the SARS-CoV-2 genome Vero cells viral RNA genome virion Virus structures [DOI] 10.1038/s41467-021-22785-x PMC 바로가기 [Article Type] Article
An mRNA-based vaccine candidate against SARS-CoV-2 elicits stable immuno-response with single doseSARS-CoV-2에 대한 mRNA 기반 백신 후보는 단일 용량으로 안정적인 면역 반응을 이끌어냅니다.Article Published on 2021-06-232022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] animal model antibody architecture CD4+ cell CD4+ cells characterization clinic coronavirus COVID D614G D614G variant domain dose elicit Extracellular Formulation Genotype HEK293 cell HEK293 cells IgG immunization immunized mice immunologic response immunologic responses implicated Infection Lipid Lipid nanoparticle LNP mRNA-based vaccine neutralized product provide pseudoviruses purified RBD responsible SARS-CoV-2 SARS-CoV-2 virus single dose Spike protein SPR stable population suggested surface plasmon surface plasmon resonance Th1 the spike protein translation vaccination Vaccine vaccine candidate [DOI] 10.1016/j.vaccine.2021.05.035 PMC 바로가기 [Article Type] Article
Anti-SARS-CoV-2 Vaccines and Monoclonal Antibodies Facing Viral Variants바이러스 변이체에 직면 한 항 -SARS-COV-2 백신 및 모노클로 날 항체Review Published on 2021-06-182022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition affected animals antibody Clusters coronavirus curative D614G Denmark effective emergence examined example France Genome Host humans Immunity mAbs mink monoclonal antibodies monoclonal antibody mutant mutants Mutation mutations Occurrence respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants several variant several variants severe acute respiratory syndrome Coronavirus severity spike gene Strains the Spike therapeutic Therapies Transmissibility transmitted Vaccine variant variants virus [DOI] 10.3390/v13061171 PMC 바로가기 [Article Type] Review
SARS-CoV-2: Origin, Evolution, and Targeting InhibitionSARS-CoV-2: 기원, 진화 및 표적 억제Review Published on 2021-06-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 진단, [키워드] (RdRp ACE2 acute respiratory diseases acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed angiotensin angiotensin converting enzyme antibodies antibody bind carried caused China comparison complex structure coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G described drug effective enzyme Evolution help host cell in viral Infection inhibit inhibition inhibitor Invasion involved mechanism MPro mutant Neutralizing antibodies neutralizing antibody non-structural proteins origin outbreak pandemic pathogenic pathogenic mechanism physiological protease Protein proteolytic RdRP receptor recognize Replication respiratory respiratory diseases responsible RNA-dependent RNA polymerase S protein SARS-CoV-2 second wave severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 small molecule small molecule inhibitor Small molecule inhibitors Spread Structure targeting targeting inhibition therapeutic target transcription processes Viral viral genome replication viral invasion Viral RNA Wuhan [DOI] 10.3389/fcimb.2021.676451 PMC 바로가기 [Article Type] Review
Characterization of SARS-CoV-2 East Java isolate, IndonesiaSARS-CoV-2 동부 자바 격리의 특성화, 인도네시아Research Article Published on 2021-06-162022-09-11 Journal: F1000Research [Category] MERS, SARS, 진단, 치료기술, [키워드] Analysis ARTIC protocol blind blind passage caused cell line chain reactions characterization clade confirmation COVID-19 COVID-19 infection Cytopathic effect D614G D614G mutation East electron microscopy exhibited gene analysis growth properties immunized immunogenicity in some inactive Indonesia Infectious disease isolate Lineage Microscopy Mutation nasopharyngeal swabs observation pandemic Patient Primers reaction regions reverse transcriptase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine scanning electron microscopy serum spike spike gene transmission electron microscopy Vero E6 virus isolation was performed western blot whole genome Whole genome sequencing [DOI] 10.12688/f1000research.53137.1 PMC 바로가기 [Article Type] Research Article
Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals이전의 SARS-COV-2 감염은 백신 접종 된 개인에 의한 B.1.1.7 교차 중립화를 증가시킨다Article Published on 2021-06-122022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B.1.1.7 B.1.1.7 variant boost coronavirus cross-neutralization D614G expressing Humoral response increase individual infected individual infecting Infection mutant natural infection neutralization neutralization breadth Neutralizing activity neutralizing response parameter pseudovirus pseudoviruses reduction in respiratory robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread tested vaccinated individual vaccinated individuals vaccination Vaccine vaccinee variant Wuhan Wuhan-Hu-1 [DOI] 10.3390/v13061135 PMC 바로가기 [Article Type] Article
Vaccine Breakthrough Infections with SARS-CoV-2 VariantsSARS-CoV-2 변이체를 사용한 백신 돌발 감염Case Reports Published on 2021-06-102022-09-11 Journal: The New England Journal of Medicine [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BNT162b2 Breakthrough infection Cohort coronavirus coronavirus disease Coronavirus disease 2019 D614G diagnose E484K Efficacy effort Evidence evidence of Infection Moderna mRNA mRNA-1273 Mutation observation of BNT162b2 Pfizer-BioNTech polymerase positive potential risk Prevent respiratory SARS-CoV-2 second dose Sequencing severe acute respiratory syndrome Coronavirus subsequent Support Symptom tested vaccination Vaccine vaccine efficacy variant variants Viral virus women [DOI] 10.1056/NEJMoa2105000 PMC 바로가기 [Article Type] Case Reports
A Comprehensive Molecular Epidemiological Analysis of SARS-CoV-2 Infection in Cyprus from April 2020 to January 2021: Evidence of a Highly Polyphyletic and Evolving Epidemic2020 년 4 월부터 2021 년 1 월까지 키프로스에서 SARS-COV-2 감염에 대한 포괄적 인 분자 역학 분석 : 고도로 다발성 및 진화 전염병의 증거Article Published on 2021-06-092022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] A222V A570D acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted affected analyses Analysis antibody Asia B.1 B.1.1.7 B.1.177 Brazil characterized clinical sample clinical samples Comprehensive concern coronavirus COVID-19 Cyprus Czech Republic D1118H D614G Denmark diagnostic diagnostic testing Epidemic epidemiological Europe European evidence of Genetic genetic analysis Germany global public health Health crisis hospitalized patients immune evasion indicated Infection initial island Italy L18F limit Lineage lineages lockdown majority measure molecular Molecular epidemiology Mutation N439K N501Y nasopharyngeal swabs outbreak P681H performed phylodynamic Phylogenetic phylogenetic analyses Phylogenetic analysis phylogeographic analysis prevalent lineage respiratory resulting retrospective S protein S982A SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates severe acute respiratory syndrome Coronavirus Slovenia Spread study period Switzerland the S protein the SARS-CoV-2 Transmissibility transmissibility of SARS-CoV-2 United Kingdom USA variant virus VoC [DOI] 10.3390/v13061098 PMC 바로가기 [Article Type] Article