hACE2 – Page 26 – Communicable Diseases Research

K18-hACE2 mice develop respiratory disease resembling severe COVID-19

K18-hACE2 쥐, 심각한 COVID-19와 유사한 호흡기 질환 발병

Research Article

Published on 2021-01-192022-08-13
Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences,

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

개코원숭이에서의 SARS-CoV-2 스파이크 당단백질 백신 후보 NVX-CoV2373 면역원성 및 마우스에서의 보호

Article

Published on 2021-01-142022-09-12
Journal: Nature Communications [Category] 비임상, 진단,

[키워드] angiotensin anti-S antibody anti-S IgG antibody Antigen Antigen-specific T cells B cell binding block CD4 CD8 clinical evaluation COVID-19 pandemic elicit elicited enzyme Evidence evidence of follicular full-length full-length spike protein functional Germinal center hACE2 hACE2 receptor helper T cell high affinity human Angiotensin-converting enzyme immunogenic immunogenicity low-dose Matrix-M mice multifunctional neutralize no evidence of NVX-CoV2373 prefusion conformation PROTECT Protective Protein Protein binding Protein vaccines receptor respiratory Respiratory disease S-protein Safe Saponin SARS-CoV-2 SARS-CoV-2 spike glycoprotein Spike protein spleen Spread subunit Subunit vaccine Support T cells Tfh Vaccine vaccine candidate virus virus infection
[DOI] 10.1038/s41467-020-20653-8 PMC 바로가기 [Article Type] Article

Contact residue contributions to interaction energies between SARS-CoV-1 spike proteins and human ACE2 receptors

Article

Published on 2021-01-132022-10-29
Journal: Scientific Reports [Category] COVID-19,

Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)

Research Article

Published on 2021-01-082022-10-28
Journal: PLoS ONE [Category] COVID-19,

[키워드] acute respiratory distress airway alleviate antiviral agent ARDS Bank COVID-19 drug Drug repurposing drugs exploration faster hACE2 hACE2 receptor human Angiotensin-converting enzyme immune system in vitro in vivo indication Infection Inflammation Influenza virus inhibit inhibitor Interaction investigated modulate molecular molecular docking pandemic peptide peptide-based pharmacological potential benefit predict predicted Prevent protein-protein interaction receptor reduced Regulatory required SARS-CoV-2 spike protein specificity Spike protein stimulate Support syndrome the SARS-CoV-2 the SARS-CoV-2 virus the spike protein Treatment viral infection
[DOI] 10.1371/journal.pone.0245258 PMC 바로가기 [Article Type] Research Article

Cross-species recognition of SARS-CoV-2 to bat ACE2

ACE2에 대한 SARS-CoV-2의 종간 인식

530

Published on 2021-01-052022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] 변종,

[키워드] Rhinolophus macrotis ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 attenuate bACE2 bat bat ACE2 bats benefit bind binding binding domain caused complex conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Evidence expressing global health hACE2 Health host cell host cells human ACE2 human ACE2 receptor infect Infection Interaction less molecular basis mutant pandemic pseudotyped pseudotyped SARS-CoV-2 virus RBD RBD binding receptor Receptor binding domain residue residues respiratory SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 spike protein receptor binding domain SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Significance Spike protein the SARS-CoV-2 Variation variations virus virus infection was determined Y41H
[DOI] 10.1073/pnas.2020216118 PMC 바로가기 [Article Type] 530

A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351

붉은 털 원숭이에서 SARS-CoV-2에 대한 강력한 효능의 인간 항체는 B.1.351에 대한 강력한 차단 활성을 나타냈습니다

Article

Published on 2021-01-012022-09-11
Journal: mAbs [Category] MERS, 변종, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody B.1.1.7 B.1.351 binding blocking activity broad-spectrum cause clinical trial Complete convalescent plasma coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 COVID-19 pandemic D614G demonstrated disease Efficacy hACE2 host cell host cell receptor in vitro Infection interact Intervention JMB2002 lead neutralization Neutralizing Neutralizing antibodies neutralizing antibody phage phage-to-yeast Phase 1 Phase 1 clinical trial platform Prophylactic Protein RBD Receptor binding domain respiratory rhesus rhesus macaque rhesus macaque disease model. SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 the RBD the SARS-CoV-2 therapeutic therapeutic efficacy Transmission Vaccine virus yeast
[DOI] 10.1080/19420862.2021.1930636 PMC 바로가기 [Article Type] Article

The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro

Research article

Published on 2021-01-012022-10-05
Journal: Biochemical pharmacology [Category] 치료법,

[키워드] activities acute lung injury administration analysis of variance ANOVAanalysis of variance average steady-state plasma concentration baicalein BALFbronchoalveolar lavage fluid Body weight loss Bronchoalveolar lavage fluid Cavgaverage steady-state plasma concentration CC50half-cytotoxic concentration cell damage Cmaxpeak plasma concentration Concentration Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 CPEcytopathic effect Cytopathic effect dengue virus DENVdengue virus EC50half-maximal effective concentrations EEPend-expiratory pause effective Effects end-expiratory pause enhanced pause H & EHematoxylin and eosin hACE2 hACE2human angiotensin-converting enzyme 2 half-cytotoxic concentration half-maximal effective concentrations Hematoxylin and eosin HIVhuman immunodeficiency virus Human angiotensin-converting enzyme 2 Human immunodeficiency virus IL-1β in vitro in vivo infected with SARS-CoV-2 inflammatory cell infiltration inhibit inhibited Injury Japanese encephalitis virus JEVJapanese encephalitis virus lesion LLOQLower Limit of Quantitation Lower Limit of Quantitation lung lung tissue main protease mice MOImultiplicity of infection morphology Mpromain protease multiplicity of infection peak expiratory flow peak plasma concentration PEFpeak expiratory flow Penhenhanced pause pharmacological reached Replication Respiratory function Result SARS-CoV-2 SARS-CoV-2severe acute respiratory syndrome coronavirus 2 Scutellaria baicalensis selection index serum severe acute respiratory syndrome coronavirus 2 significantly SIselection index therapeutic drug therapeutic effect TNF-α transgenic mice Treatment Vero E6 cell virus was performed Zika virus ZIKVZika virus
[DOI] 10.1016/j.bcp.2020.114302 [Article Type] Research article

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

K18-hACE2 마우스의 후각 상실을 포함한 COVID-19 치료 및 발병 기전

Article

Published on 2021-01-012022-09-11
Journal: Nature [Category] Fulltext, SARS, 임상, 치료기술, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animals Anosmia Asymptomatic Brain cause clinical disease convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 treatment disease evidence of example feature hACE2 in some Infection infection with SARS-CoV-2 investigated K18-hACE2 mice K18-hACE2 transgenic mice lethal disease lung mice Mild Mild disease morbidity and mortality pandemic Pathogenesis Patient patient with COVID-19 patients Prevent prevented respiratory respiratory symptom SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease severe pneumonia severity of COVID-19 the disease therapeutic interventions thrombosis Vasculitis
[DOI] 10.1038/s41586-020-2943-z PMC 바로가기 [Article Type] Article

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2

중증 급성 호흡기 증후군 코로나바이러스 2에 대한 적응 면역 반응 연구를 위해 쥐에서 mRNA 유도 인간 안지오텐신 전환 효소 2 발현

Research Article

Published on 2020-12-162022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Antigen Antiviral Author caused CD4+ CD4+ T cell CD8+ CD8+ T cell cells cloned coronavirus Critical demonstrated Efficacy entry of SARS-CoV-2 Epitopes expressed expression functional hACE2 hACE2 receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human coronavirus humans immune response in vivo induce Infection information interferon receptor Laboratory lack membrane Membrane proteins memory mice mRNA mRNA expression mRNA transfection mRNA-based murine murine model murine models nucleocapsid pandemic peptide peptide epitope peptides preserved provided receptor Replication required respiratory response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis Secondary infection severe acute respiratory syndrome Coronavirus Spike proteins strain T cell T cell epitope T cell epitopes T cell response T cells this system type 1 interferon unique Vaccine vaccine efficacy Vaccines virus
[DOI] 10.1371/journal.ppat.1009163 PMC 바로가기 [Article Type] Research Article

In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species

S 단백질을 사용한 인간 ACE2의 in silico 돌연변이 유발 및 번역 효율성은 다른 종의 SARS-CoV-2 감염성을 설명합니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Computational Biology [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 variant ACE2 variants addressed affecting affinity allelic Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding cats caused cellular entry coronavirus coronavirus disease coronavirus disease COVID-19 Coronavirus infection COVID-19 pandemic death difference domain early stage Efficiency enzyme explain expression level expression levels Factor Factors feature ferrets Genomic variability hACE2 host protein host proteins Human human ACE2 human angiotensin converting enzyme 2 human cell human cells humans immune response in silico in some in viral individual infect Infection integration Interaction interface mice modify Mutagenesis new virus pandemic PIGS protein-protein interaction proteome RBD domain recognize reported S protein SARS-CoV-2 SARS-CoV-2 virus second sensitivity sequence species Spike protein stability the RBD the SARS-CoV-2 translated translation translational tRNA Variability variant Viral viral infectivity viral mutation Viral protein Viral proteins virus virus isolate waters
[DOI] 10.1371/journal.pcbi.1008450 PMC 바로가기 [Article Type] Research Article