A Comprehensive Molecular Epidemiological Analysis of SARS-CoV-2 Infection in Cyprus from April 2020 to January 2021: Evidence of a Highly Polyphyletic and Evolving Epidemic2020 년 4 월부터 2021 년 1 월까지 키프로스에서 SARS-COV-2 감염에 대한 포괄적 인 분자 역학 분석 : 고도로 다발성 및 진화 전염병의 증거Article Published on 2021-06-092022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] A222V A570D acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted affected analyses Analysis antibody Asia B.1 B.1.1.7 B.1.177 Brazil characterized clinical sample clinical samples Comprehensive concern coronavirus COVID-19 Cyprus Czech Republic D1118H D614G Denmark diagnostic diagnostic testing Epidemic epidemiological Europe European evidence of Genetic genetic analysis Germany global public health Health crisis hospitalized patients immune evasion indicated Infection initial island Italy L18F limit Lineage lineages lockdown majority measure molecular Molecular epidemiology Mutation N439K N501Y nasopharyngeal swabs outbreak P681H performed phylodynamic Phylogenetic phylogenetic analyses Phylogenetic analysis phylogeographic analysis prevalent lineage respiratory resulting retrospective S protein S982A SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates severe acute respiratory syndrome Coronavirus Slovenia Spread study period Switzerland the S protein the SARS-CoV-2 Transmissibility transmissibility of SARS-CoV-2 United Kingdom USA variant virus VoC [DOI] 10.3390/v13061098 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic reviewSARS-CoV-2 변이체 및 관련 이환율 및 사망률의 특성화: 체계적인 검토Review Published on 2021-06-082022-09-10 Journal: European Journal of Medical Research [Category] MERS, SARS, 변종, 치료법, [키워드] alteration Amino acid article characterization Characterizations clade clinical manifestation clinical manifestations conducted coronavirus coronavirus disease coronavirus disease-2019 COVID-19 D614G database Deleterious demonstrated English Evidence genomic diversity genomic variants global pandemic Gujarat in viral Intervention life-threatening Missense mutation Missense mutations morbidity morbidity and mortality Mortality Mutation Nsp12 nucleocapsid ORF3a pandemic Pathogenesis Patient Prevent researcher Result retrieved S protein S proteins SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant Science Science Direct several variant several variants shown significantly Strains systematic review trajectory Transmissibility variant variants variants of SARS-CoV-2 Viral viral pathogenesis Web of Science Wuhan Wuhan, China [DOI] 10.1186/s40001-021-00524-8 PMC 바로가기 [Article Type] Review
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7SARS-CoV-2 스파이크 결실 H69/V70의 반복적인 출현과 알파 변이체 B.1.1.7에서의 역할Article Published on 2021-06-082022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Abstract ACE2 receptor acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Alpha variant antibody antibody escape B.1.1.7 binding affinity cell entry cell-cell fusion cleaved coronavirus COVID-19 D614G Deletion deletions dependent on Effect Efficiency escape escape mutation faster functional immune escape mutation immune escape mutations impair increase independent lineages Infectivity loss of infectivity mechanism N439K Neutralizing antibodies occur Pseudotyped virus receptor binding motif Recurrent replacement report residue resistance respiratory SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus spike spike mutation Spike protein Spike proteins Surveillance syncytium formation The B.1.1.7 the SARS-CoV-2 virion virions wild-type Wuhan-1 Y453F [DOI] 10.1016/j.celrep.2021.109292 PMC 바로가기 [Article Type] Article
A Biochemical Perspective of the Nonstructural Proteins (NSPs) and the Spike Protein of SARS CoV-2비구조 단백질(NSP)과 SARS CoV-2의 스파이크 단백질에 대한 생화학적 관점Review Published on 2021-06-012022-09-11 Journal: The protein journal [Category] SARS, 변종, [키워드] 501Y.V1 501Y.V2 ACE2 receptor aspartate caused change Chemistry D614G effort ENhance Enzymes global pandemic glycine Host increasingly Interaction N501Y nonstructural protein nonstructural proteins Nsp12 nsp13 nsp14 Nsp15 Nsp3 nsp5 pandemic position Proteases Proteins Receptor binding domain SARS CoV SARS CoV-2 Spike protein strain the Spike the spike protein variant Viral proteins virus [DOI] 10.1007/s10930-021-09967-8 PMC 바로가기 [Article Type] Review
Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clustersCOVID-19 패밀리 클러스터로부터 분리 된 SARS-COV-2의 분자 역학Research Published on 2021-06-012022-09-01 Journal: BMC Medical Genomics [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Amino acid Analysis change clade Cluster Clusters collected Combination COVID-19 COVID-19 severity D614G D614G mutation dataset Deceased disease epidemiological data Epidemiology Families family Family cluster Frame Genome highlight Illumina Miseq Indonesia Infection involved Multiple spike protein mutations Mutation mutations next-generation sequencer nucleic acid Open reading frame ORF outcomes Patient patients patients with COVID-19 Phylogenetic analysis Protein Q677H regions Result resulting SARS-CoV-2 SARS-CoV-2 transmission sequence sequences SNP Spike protein supplementary material survived transmission of SARS-CoV-2 virus virus sample virus samples viruses was performed Whole genome sequencing [DOI] 10.1186/s12920-021-00990-3 PMC 바로가기 [Article Type] Research
Different SARS-CoV-2 haplotypes associate with geographic origin and case fatality rates of COVID-19 patients다양한 SARS-CoV-2 일배체형은 COVID-19 환자의 지리적 기원 및 사례 치사율과 관련이 있습니다.Article Published on 2021-06-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] allelic allelic variant approach association bioinformatics Case fatality rate caused COVID-19 COVID-19 case COVID-19 patient D614G D614G mutation Factor Fatality risk Genotype genotyping Geographic Haplotype haplotypes Haplotypes - geno-to-pheno correlation involved mechanism nucleotide pandemic of COVID-19 Pathogenesis pathogenic polymorphism question regions SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 virus sequence severity Single nucleotide polymorphism SNP statistically significant strain Strains the SARS-CoV-2 virus variant Variation viral genome virus while [DOI] 10.1016/j.meegid.2021.104730 PMC 바로가기 [Article Type] Article
A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity유리한 생체 분포 패턴과 유망한 면역성을 지닌 코어 쉘 구조의 COVID-19 mRNA 백신Article Published on 2021-05-312022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 비임상, 임상, 진단, 치료제, [키워드] addition administration biodistribution composed COVID-19 COVID-19 vaccine COVID-19 vaccines Critical D614G effective effective vaccine Extensive facilitate full-length SARS-CoV-2 full-length SARS-CoV-2 spike protein humans Immunity inoculation intramuscular levels of antibody liver LPP mice mRNA mRNA vaccine N501Y Neutralizing non-human primate non-human primates packaged Protein Safe SARS-CoV-2 spike Spike protein stability T cell T cell response Translational research unique Vaccine vaccine candidate Vaccines variant variants wild-type SARS-CoV-2 [DOI] 10.1038/s41392-021-00634-z PMC 바로가기 [Article Type] Article
Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9Research Article Published on 2021-05-282022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Bacterial Biomarker Campylobacter jejuni Cas9 Cas9 nuclease cellular cellular RNA complexes coronavirus CRISPR CRISPR-Ca CRISPR-Cas9 D614G Defense detect diagnostic Diagnostic method DNA example genetic material Genome guide RNA Host hybridizing orthologs Patient platform PROTECT recognize RNA RNAs SARS-CoV-2 Science transcript variant viral DNA virus viruses while [DOI] 10.1126/science.abe7106 PMC 바로가기 [Article Type] Research Article
Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-22020년 2월 어린이의 다기관 염증 증후군 및 SARS-CoV-2에 대한 게놈 시퀀싱의 의미Case Reports Published on 2021-05-282022-09-11 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused children complicate coronavirus COVID-19 D614G D614G variant described disease Europe Infection Inflammatory Lineage MIS-C outbreak Patient predominant pseudotumor cerebri syndrome SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein syndrome the spike protein the United State United States viral lineage. [DOI] 10.1093/jpids/piaa167 PMC 바로가기 [Article Type] Case Reports
Molecular dynamics analysis of N-acetyl-D-glucosamine against specific SARS-CoV-2’s pathogenicity factorsResearch Article Published on 2021-05-272022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] 6M0J Analysis antibody bacterial cell binding carried computational analysis cough D614G domain ectodomain effective evade Factor Fever Host immune response immune system induce Infection inhibit manipulative MERS mimicking molecular molecular docking molecular docking analysis molecular dynamics mutant Mutation neutralizing antibody not affected nucleocapsid occurred pandemic pathogenicity performed Predictive protease Protein protein-ligand interaction Proteins Receptor binding domain responsible SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 S SARS-CoV-2 spike selected Severe case severe respiratory illness Shortness of breath shown Staphylococcus aureus supported Symptom temperature the SARS-CoV-2 virus trimer virus [DOI] 10.1371/journal.pone.0252571 PMC 바로가기 [Article Type] Research Article