hACE2 – Page 27 – Communicable Diseases Research

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

SARS-CoV-2를 무력화하는 강력하고 탄력적인 hACE2 미끼의 새로운 설계

Report

Published on 2020-12-042022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 치료제,

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice

K18 인간 안지오텐신 전환 효소 2 형질전환 마우스에서 SARS-CoV-2 감염의 치사율

Article

Published on 2020-11-302022-09-10
Journal: Nature Communications [Category] 치료기술,

[키워드] airway epithelium angiotensin angiotensin converting enzyme animal model animal models Antiviral benefit both lungs Brain characterization chemokine COVID-19 disease cytokeratin 18 promoter cytokine Cytokine storm enzyme expressing hACE2 human angiotensin converting enzyme 2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 induce Infection K18 K18-hACE2 lethality lung mice Pathogenesis peaked produced Prophylactic SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease spleen susceptible therapeutic Therapeutics transgenic mice Vaccine Viral viral infection viral pathogenesis virus
[DOI] 10.1038/s41467-020-19891-7 PMC 바로가기 [Article Type] Article

NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

NVX-CoV2373 백신은 SARS-CoV-2 공격으로부터 사이노몰구스 마카크 상부 및 하부 기도를 보호합니다.

Article

Published on 2020-11-252022-09-12
Journal: Vaccine [Category] SARS, 진단,

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

SARS-CoV-2 감염의 3가지 동물 모델에서 높은 예방 및 치료 효능을 가진 인간 항체의 신속한 식별

530

Published on 2020-11-242022-09-12
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단,

[키워드] Ab1 ACE2 ADCC ADCC activity Administered aggregate aggregation animal model animal models antibody antibody-dependent cellular cytotoxicity Antigen assays BALB/c mice binding Combination competition Complete Coronaviruses COVID-19 Culture dose effective Efficacy elicited exhibited expressing Fab glycoprotein hACE2 hamster hamsters human ACE2 human cell human cell membrane human monoclonal antibodies Human monoclonal antibody IgG1 in vitro inhibited lack lowest mAb mAbs mechanism microbes monoclonal neutralization neutralized pandemic Prophylactic prophylactically Prophylaxis Protein Proteins public health threat Rapid RBD Receptor binding domain replication-competent SARS-CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 replication SARS-CoV-2 spike scFv sequence Significance somatic mutations tested the SARS-CoV-2 therapeutic antibodies therapeutic efficacy therapy tissue tissue culture transgenic mice Vaccines virus virus infection was selected wild-type
[DOI] 10.1073/pnas.2010197117 PMC 바로가기 [Article Type] 530

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

SARS-CoV-2 성장, 퓨린 절단 부위 적응 및 급성 감염 입원 COVID-19 환자의 혈청을 사용한 중화

Research Article

Published on 2020-11-212022-09-10
Journal: The Journal of General Virology [Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptation angiotensin antigenic target Betacoronavirus both viruses causative agent caused Cell cell lysate cell surface cells characterized cleavage clinical isolates comparable coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deaths deleted Deletion demonstrated disease expand furin furin cleavage generate glycoprotein growth hACE2 Healthcare system Healthcare systems hospitalized COVID-19 patient host range human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo indirect immunofluorescence inefficient Infection insertion investigated Like MinION Munich neutralization Neutralizing antibodies neutralizing antibody titre neutralizing antibody titres Pathogenesis patients reached receptor respiratory S glycoprotein S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 spike Sequencing serum serum sample severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spread to strain the cell the S protein the SARS-CoV-2 variant Vero E6 Vero E6 cell VERO E6 cells virus virus stock virus stocks viruses
[DOI] 10.1099/jgv.0.001481 PMC 바로가기 [Article Type] Research Article

Sensitization of Non-permissive Laboratory Mice to SARS-CoV-2 with a Replication-Deficient Adenovirus Expressing Human ACE2

인간 ACE2를 발현하는 복제 결핍 아데노바이러스를 사용한 SARS-CoV-2에 대한 비허용 실험용 쥐의 감작

Article

Published on 2020-11-092022-09-11
Journal: STAR protocols [Category] SARS, 치료기술,

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection

Research Article

Published on 2020-11-062022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS,

Effective screening of SARS-CoV-2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein

Article

Published on 2020-11-052022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

[키워드] 293T biosafety convalescent patient Efficiency expressing full-length G glycoprotein glycoprotein hACE2 highly pathogenic IgG levels lentiviral lentivirus mammalian cell mammalian cells Microbiology much higher neutralized Particle Patient Preclinical research produced provide pseudotype pseudotyped Pseudotyped virus recovered COVID-19 patient retroviral SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 receptor SARS-CoV-2 spike glycoprotein SEROLOGICAL STUDY serum specific IgM specific neutralizing antibody spike tested the SARS-CoV-2 transduced vesicular stomatitis virus Virology virus VSV-G while
[DOI] 10.1038/s41598-020-76135-w PMC 바로가기 [Article Type] Article

De novo design, retrosynthetic analysis and combinatorial synthesis of a hybrid antiviral (VTAR-01) to inhibit the interaction of SARS-CoV2 spike glycoprotein with human angiotensin-converting enzyme 2

Research Article

Published on 2020-10-152022-10-27
Journal: Biology open [Category] COVID-19,

[키워드] De novo designing ACE2 Analysis angiotensin converting enzyme 2 Antiviral antiviral molecule Ascorbate bind binding caused complex COVID-19 disease de novo dependent on docking domain enzyme hACE2 high mortality human Angiotensin-converting enzyme Hybrid antiviral molecule Hydroxychloroquine Infection inhibit interact Interaction MDs molecular Molecular dynamics simulation morbidity outbreak Pathogenesis Protein RBD RBD-ACE2 recognize responsible Retrosynthetic analysis ribavirin SARS-CoV2 SARS-CoV2 spike glycoprotein SARS-like coronavirus spike spike glycoprotein Spike protein tested the receptor-binding domain variant virus were used
[DOI] 10.1242/bio.054056 PMC 바로가기 [Article Type] Research Article

De novo design, retrosynthetic analysis and combinatorial synthesis of a hybrid antiviral (VTAR-01) to inhibit the interaction of SARS-CoV2 spike glycoprotein with human angiotensin-converting enzyme 2

Research Article

Published on 2020-10-152022-10-27
Journal: Biology open [Category] Coronavirus, COVID-19, Fulltext,

[키워드] De novo designing ACE2 Analysis angiotensin converting enzyme 2 Antiviral antiviral molecule Ascorbate bind binding caused complex COVID-19 disease de novo dependent on docking domain enzyme hACE2 high mortality human Angiotensin-converting enzyme Hybrid antiviral molecule Hydroxychloroquine Infection inhibit interact Interaction MDs molecular Molecular dynamics simulation morbidity outbreak Pathogenesis Protein RBD RBD-ACE2 recognize responsible Retrosynthetic analysis ribavirin SARS-CoV2 SARS-CoV2 spike glycoprotein SARS-like coronavirus spike spike glycoprotein Spike protein tested the receptor-binding domain variant virus were used
[DOI] 10.1242/bio.054056 PMC 바로가기 [Article Type] Research Article