Comparative performance data for multiplex SARS-CoV-2 serological assays from a large panel of dried blood spot specimensResearch article Published on 2022-08-282022-10-05 Journal: Heliyon [Category] 유전자 메커니즘, [키워드] Anti-spike Antibody titers assays binding domain Bio-rad Blood Canada collected Comparative convalescent COVID-19 patient COVID-19 COVID-19 pandemic DBS sample Direct Dried blood spots Elecsy evaluated IgG immunoassays individual Infection Mount Sinai MSD multiple antigen multiplex observé Panel protocols RBD resulting Roche SARS-CoV-2 SARS-CoV-2 antibody testing SARS-CoV-2 IgG sensitivity Serological assay serology Serosurvey Serosurveys specificity specimen transmitted university [DOI] 10.1016/j.heliyon.2022.e10270 [Article Type] Research article
Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patientsArticle Published on 2022-08-272022-10-05 Journal: Cell Death & Disease [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] acute phase addition analyzed anti-S Anti-spike antibody-dependent cellular cytotoxicity Apoptosis apoptotic build CD4 T cell CD4 T-cell Cell contribute Convalescent patients coronavirus 2 correlated COVID-19 COVID-19 patient CXCL10 death demonstrated disease severity early phase help humoral IgA IgG IgG response IgM Immunoglobulin individual infected individual infected individuals Infection inflammatory reaction lymphopenia magnitude marker membrane neutralization pathogenicity Patient plasma predominant programmed cell death Proteins reducing reported respiratory response responses SARS-CoV-2 nucleocapsid soluble Fas ligand specific IgG antibodies T-cell the S protein [DOI] 10.1038/s41419-022-05190-0 [Article Type] Article
IgG Against Human Betacoronavirus Spike Proteins Correlates With SARS-CoV-2 Anti-Spike IgG Responses and COVID-19 Disease SeverityArticle Published on 2022-08-262022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome Against anti-S anti-S antibody anti-S2 anti-SARS-CoV-2 antibody Anti-spike antibody Antibody Response bidirectional cohorts common cold common cold human coronaviruses (HCoVs) coronavirus correlated COVID-19 cross-react cross-reactive antibody cross-reactive antibody response decrease disease disease severity domain Effect elicited HKU1 homologous Human human coronavirus IgG IgG antibody immune immune imprinting. Immunoglobulin morbidity and mortality Multiplex assay OC43 Organ failure Protective RaTG13 recognizing response S proteins S1-reactive antibodies SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection sera serum sample severe coronavirus disease Severity of disease significantly increased SOFA spike strain subject with COVID-19 [DOI] 10.1093/infdis/jiac022 PMC 바로가기
Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria: Updated Analysis Involving 22,607 Blood Donors Covering the Period October 2021 to April 2022Article Published on 2022-08-252022-11-15 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] age anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-Spike IgG anti-spike IgG antibodies antibody average Blood Blood donors category Covering detectable estimate female geometric IgG IgG antibody IgG level incidence individual infected with SARS-CoV-2 Involving median P -value participant percentage Period proportion public health quantified remained required SARS-CoV-2 seropositive participant seropositive participants Seroprevalence undetectable vaccinated individual [DOI] 10.3390/v14091877 PMC 바로가기
Host Predictors of Broadly Cross-Reactive Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern Differ Between Infection and Vaccination중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 광범위한 교차 반응성 항체의 숙주 예측 인자는 감염과 예방 접종 사이에 차이가 있습니다.Observational Study Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against antibody Antibody Response B.1.1.7 B.1.351 B.1.617.2 BMI booster Clinical characteristics clinician Clinicians Cohort collected concern contributed coronavirus coronavirus 2 cross-reactive cross-reactive antibodies cross-reactive antibody disease severity enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Factor Health healthy highest Host identify IgG IgG antibodies IgG antibody IgG level immunization Immunocompromised Immunoglobulin Immunoglobulin G individual Infection information metabolic health mounted mRNA vaccination P.1 participant plasma sample plasma samples Population populations predict prospective observational cohort Protective Protective antibody RBD Receptor binding domain Regression model regression models researchers respiratory responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spike receptor binding domain tested These data vaccination Vaccine Variability variants variants of concern Viral Viral variants virus variants Wuhan younger people [DOI] 10.1093/cid/ciab996 PMC 바로가기 [Article Type] Observational Study
Evidence for deleterious effects of immunological history in SARS-CoV-2SARS-CoV-2에서 면역학적 병력의 유해한 영향에 대한 증거Article Published on 2022-08-242022-09-11 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] Amino acid amino acid change antibodies binding antibody Antigen antigenic association binding binding assay Binding assays blood sample COVID-19 disease COVID-19 disease severity COVID-19 infections cross-reactive cross-reactivity deleterious effect demonstrated epitope H3N2 hallmark hallmarks homologous identify IgG immunological Immunological memory Infection Influenza influenza A influenza A virus influenza infection influenza strain influenza vaccine Injury Patient presence of antibody Protein SARS-CoV-2 SARS-CoV-2 nucleocapsid sequence severe COVID-19 infections underlie upregulation Vaccine widespread [DOI] 10.1371/journal.pone.0272163 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RBD-Specific Antibodies Induced Early in the Pandemic by Natural Infection and Vaccination Display Cross-Variant Binding and InhibitionArticle Published on 2022-08-242022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding acute respiratory syndrome angiotensin-converting enzyme 2 antibody approved Beta binding BNT162b2 ChAdOx1 nCoV-19 circulating collected coronavirus country COVID-19 cross-reactive cross-reactivity Denmark display dose Efficacy examined Gamma greater IgG Immunity induced infected with SARS-CoV-2 inhibited inhibition inhibitory less mechanisms natural natural infection omicron Oxford-AstraZeneca pandemic Pfizer-BioNTech receptor Receptor binding domain reduced regimen response SARS-CoV-2 Strains subject subjects susceptibility sustained symptomatic transmission rate vaccination Vaccine vaccine candidate variant variants of concern were used wild-type [DOI] 10.3390/v14091861 PMC 바로가기
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSARS-CoV-2 항체의 구조 연구는 스파이크 삼량체를 분해하여 오미크론 변이체를 중화하는 광범위한 항체를 식별합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation antibody caused conservation conserved convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy cryo-EM develop Effectiveness electron microscopy epitope Epitopes function hidden IgG Immune escape investigated monoclonal antibodies monoclonal antibody NAb NAbs neutralize Neutralizing antibodies neutralizing antibody omicron Omicron variant pandemic Protein pseudovirus raised raising RBD reagent Receptor binding Receptor binding domain respiratory S trimer S trimers SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants steric hindrance subset target the SARS-CoV-2 the Spike therapeutic therapy trimer Vaccines variant variants of SARS-CoV-2 virion virus VoC VOCs [DOI] 10.1128/jvi.00480-22 PMC 바로가기 [Article Type] Article
Correlation between In Vitro Neutralization Assay and Serological Tests for Protective Antibodies DetectionArticle Published on 2022-08-242022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, 치료기술, [키워드] 2019-nCoV Accuracy alternative method analyses antibodies assays Biosafety Level 3 coefficients correlation detection diagnostics Elecsy ELISA Epidemiological study Epidemiology Euroimmun gold standard highest humoral Humoral immunity IgG immunoassay individual Kappa coefficient Linear regression neutralizing antibody operators outcome Pearson performed plaque reduction neutralization plaque reduction neutralization test (PRNT) positive Predictive PRNT Protective antibody protective immunity reference method ROC ROC Curve Roche S-RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S sensitivity serological serological test serum samples Spearman Spearman coefficient specificity Spread surrogate virus neutralization test (sVNT). sVNT Test virus neutralization test [DOI] 10.3390/ijms23179566 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 특이적 T 세포 및 항체, 코로나바이러스 질병 2019(COVID-19) 보호: 전향적 연구Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed antibody Antibody Response Antibody responses CD4+ CD8+ T cell CD8+ T cells clinical comparable coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 demonstrated ELISPOT enzyme enzyme-linked immunosorbent evaluated flow cytometry followed by fraction Fractions frequencies Frequency healthcare highest IFN-γ IgG immune immune response Immunoglobulin Immunoglobulin G immunoglobulin M individual Infection interferon gamma interleukin interleukin 2 Kaplan-Meier estimator membrane nucleocapsid pandemic positive Probability Prospective PROTECT protective effect question Registration respiratory response SARS-CoV-2 SARS-COV-2 infection Spike protein Spike proteins staining T cell T cells T-cell T-cell and antibody responses T-cell Response T-cell responses the SARS-CoV-2 virus virus-specific antibodies Virus-specific IgG were infected with infection [DOI] 10.1093/cid/ciac278 PMC 바로가기 [Article Type] Article