Prevalence of SARS-CoV-2 Antibodies in Children and Adults with Type 1 Diabetes제1형 당뇨병이 있는 소아 및 성인에서 SARS-CoV-2 항체의 유병률Article Published on 2021-07-012022-09-11 Journal: Diabetes technology & therapeutics [Category] MERS, SARS, 진단, 치료법, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Care children coronavirus COVID-19 COVID-19 disease COVID-19 infections death diabete diabetes diagnosed disease Evidence General population Hospitalization individual Infection New-onset not differ not different positive Prevalence prevalence of COVID-19 remained Research design respiratory risk factor SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody severe acute respiratory syndrome Coronavirus severe symptoms subset the antibody Type Type 1 diabetes with COVID-19 Youth [DOI] 10.1089/dia.2020.0609 PMC 바로가기 [Article Type] Article
High Dose Lopinavir/Ritonavir Does Not Lead to Sufficient Plasma Levels to Inhibit SARS-CoV-2 in Hospitalized Patients With COVID-19Pharmacology Published on 2021-07-012022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antiviral effect antivirals clinical benefit Concentration COVID-19 COVID-19 patient COVID-19 positive patient defined dose EC50 exhibit female High dose hospital in vivo In-vitro interquartile range IQR large trial Level Loading dose Lopinavir Lopinavir/ritonavir LPV median age no difference not differ pandemic Patient plasma plasma concentration positive correlation Protein Ritonavir SARS-CoV-2 severe COVID-19 significantly significantly higher Spearman Steady state Tablet Treatment trough unlikely were measured [DOI] 10.3389/fphar.2021.704767 PMC 바로가기 [Article Type] Pharmacology
Rapid diagnostic testing for SARS-CoV-2: Validation and comparison of three point-of-care antibody testsSARS-CoV-2에 대한 신속한 진단 테스트: 3가지 현장 진료 항체 테스트의 검증 및 비교Article Published on 2021-07-012022-09-11 Journal: Journal of medical virology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody test antibody tests Chain Reaction Clinical practice collected Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect diagnostic diagnostic test diagnostic tests evaluated IgG IgM Immunoglobulin Negative predictive value not differ Patient plasma POC point-of-care point-of-care test polymerase chain reaction positive predictive values Rapid respiratory reverse transcription Reverse transcription-polymerase chain reaction routine clinical practice RT-PCR RT-PCR diagnosis SARS-CoV-2 sensitivities sensitivity serum serum sample severe acute respiratory syndrome Coronavirus significantly Specificities specificity tested validation Whole blood Z-tests [DOI] 10.1002/jmv.26913 PMC 바로가기 [Article Type] Article
Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccineSARS-CoV-2 및 BNT162b2 mRNA COVID-19 백신에 대한 항체의 효율적인 산모-신생아 전달Multicenter Study Published on 2021-07-012022-09-12 Journal: The Journal of Clinical Investigation [Category] SARS, 진단, [키워드] Antenatal anti-S antibody approach assigned Biology BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 mRNA vaccine collected Control COVID-19 COVID-19 vaccine Effectiveness efficient elicit Evidence fetal fetal blood first dose foundation humoral IgG IgG and IgM IgG response IgM response immune response immunoglobulins induce Infection lack Maternal mother multicenter Neonatal Neonates Newborn not differ Obstetrics/gynecology offspring Panel parturient PCR-confirmed Placenta Pregnancy pregnant women presenting RBD recruited Reproductive Biology. risk robust SARS-CoV-2 Science significantly lower transfer umbilical vaccination Vaccine Weizmann were measured [DOI] 10.1172/JCI150319 PMC 바로가기 [Article Type] Multicenter Study
Impact of SARS-CoV-2-Pandemic on Mental Disorders and Quality of Life in Patients With Pulmonary Arterial HypertensionPsychiatry Published on 2021-06-242022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] Affect Anxiety arterial baseline Care category changes in COVID-19 pandemic Depression EQ-5D Follow-up Impact life measure median Mental disorder mental health not affected not differ PAH pandemic Patient Perceived pulmonary pulmonary arterial hypertension Quality Quality of life question Regulation Safe scale significant changes in therapy timepoint were assessed [DOI] 10.3389/fpsyt.2021.668647 PMC 바로가기 [Article Type] Psychiatry
Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?Endocrinology Published on 2021-06-232022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS, [키워드] ACE ACE inhibitors ACE2 activated ADAM9 AGT Angiotensin-converting enzyme aptamer case-control study Cell class clinical co-expressed cofactor Control controls COVID-19 determine disintegrin elevated endothelial ENhance enzyme Glucose growth factor hypoglycemia Increased increased risk inhibitor Ligand mechanism Neuropilin-1 no difference not differ not different NRP1 plasma plasma protein promote protection Protective proteolytic RAS Registration remained REN response Result SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection SEMA3A serum slow stratified Stress subject subsequent System T2D therapy Type type 2 diabete type 2 diabetes VEGF [DOI] 10.3389/fendo.2021.665134 PMC 바로가기 [Article Type] Endocrinology
Obesity Strongly Predicts COVID-19-Related Major Clinical Adverse Events in Coptic ClergyArticle Published on 2021-06-222022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Adverse adverse event adverse events age Analysis cardiovascular disease cardiovascular risk factors cardiovascular system Clergy clinical Coptic clergy COVID-19 COVID-19-related complications death died Europe group hypertension identify increased risk independent Infection Interaction International less MAE MAEs Major major adverse events management mechanical ventilation not differ obese obesity pandemic participant predicted predictor Prevalence prevalence of COVID-19 prevalent recommendation risk factor source of infection suffered the WHO USA were assessed were infected [DOI] 10.3390/jcm10132752 PMC 바로가기 [Article Type] Article
Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients입원한 COVID-19 환자의 비타민 D 대사 산물 및 임상 결과Article Published on 2021-06-222022-09-10 Journal: Nutrients [Category] MERS, SARS, 바이오마커, [키워드] Admission calcium clinical Clinical course clinical courses Clinical data Clinical outcome Cohort Concentration Course COVID-19 COVID-19 patient COVID19 CRP cytokine Cytokine storm Degradation degradation products determined by died females Frequency functions Graz hospital hospital information systems hospitalized COVID-19 patient IL-6 immune response information Information Systems Laboratory male marker mechanical ventilation metabolism metabolite Non-survivors not differ Older outcome patients peak concentration peak concentrations phosphate required Retrospective study serum serum concentrations serum sample significantly Support survivor Survivors university university hospital Vitamin D vitamin D metabolites Vitamin D status [DOI] 10.3390/nu13072129 PMC 바로가기 [Article Type] Article
Impact of the COVID-19 pandemic on drug treatment of patients with peripheral arterial disease: an observational cross-sectional studyOriginal Article Published on 2021-06-172022-10-30 Journal: Jornal Vascular Brasileiro [Category] COVID-19, [키워드] Anxiety claudicação intermitente claudication COVID-19 COVID-19 pandemic cross-sectional DAP database Depression disease Diseases drug drug treatment drugs greater group groups Health Impact impairment intermittent claudication Isolamento Social Neste not differ objective Pandemia pandemic Patient Precaution proportion questionnaire recruited reported Result saúde SARS-CoV-2 social isolation Stress the patient tratamento medicamentoso Treatment two group [DOI] 10.1590/1677-5449.210021 PMC 바로가기 [Article Type] Original Article
A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19Research article Published on 2021-06-172022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 1:1 95% CI ACE2 Adverse affected all-cause hospitalization analyzed angiotensin receptor blocker ARBs Arm Biotechnology blinded Cell clinically Community contributing to COVID-19 did not reduce disease disrupting Dyspnea Effects Efficacy enrolled enzyme event event rate expected finding functional funding Genomics glomerular filtration rate hospital Hospitalization hospitalizations likelihood losartan Lung injury Mild mitigate multicenter not differ outcome Outpatient outpatients participant Participants partnership Patient Placebo placebo-controlled Primary outcome proportion RAAS Randomized randomized clinical trial RCT Replication SARS-CoV-2 virus secondary significantly statistically Support supported symptom onset symptomatic symptomatic COVID-19 disease temperature treat Treatment treatment group Trial viral entry Viral load was reduced were blinded with COVID-19 [DOI] 10.1016/j.eclinm.2021.100957 [Article Type] Research article