Secondary outcomes – Page 27 – Communicable Diseases Research

Impact of implementation of an individualised thromboprophylaxis protocol in critically ill ICU patients with COVID-19: A longitudinal controlled before-after study

COVID-19가 있는 중환자 중환자실 환자에서 개별화된 혈전 예방 프로토콜 시행의 영향: 종단적으로 통제된 전후 연구

Article

Published on 2020-10-012022-09-11
Journal: Thrombosis research [Category] 바이오마커,

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers A Randomized Clinical Trial

의료 종사자의 사전 노출 SARS-CoV-2 예방을 위한 하이드록시클로로퀸 대 위약의 효능 및 안전성 무작위 임상 시험

Randomized Controlled Trial

Published on 2020-09-302022-08-13
Journal: JAMA Internal Medicine [Category] Fulltext, MERS, 임상,

[키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered adverse effects adverse event Arm ARMS Asymptomatic baseline Care clinical clinical benefit Clinical outcome clinical outcomes clinical trial clinically cohorts conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect determined by double-blind effective Efficacy Enrollment evaluate exposure to finding Follow-up Frequency futility HCW HCWs Health Health care Health care worker health care workers hospital Hospitalization hospitals Hydroxychloroquine Identifier Importance incidence individual infection rate infection rates knowledge measure median median age Nasopharyngeal swab no significant difference not differ Nurses objective outcome participant Participants Patient patients with COVID-19 per day pharmacologic prophylaxis Philadelphia Physicians Placebo placebo-controlled placebo-controlled clinical trial Point polymerase chain positive result Prevent prevention Primary outcome Prophylaxis prophylaxis strategy QTc QTC prolongation Randomized randomized clinical trial receive reduce regimen Registration Relevance required respiratory Result reverse-transcriptase polymerase chain reaction risk Safety SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2–positive secondary Secondary outcomes setting severe acute respiratory syndrome Coronavirus significant difference Transmission transmission of SARS-CoV-2 Treatment Trial Trial registration Viral women worker
[DOI] 10.1001/jamainternmed.2020.6319 PMC 바로가기 [Article Type] Randomized Controlled Trial

Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)

COVID-19 치료를 위한 중재: 메타 분석 및 시험 순차 분석을 통한 살아있는 체계적인 검토(The LIVING Project)

Research Article

Published on 2020-09-172022-08-13
Journal: PLoS Medicine [Category] Biochemistry, COVID-19, SARS,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus Admission adverse event adverse events aggregate data meta-analyses all age group all age groups all-cause mortality assessment caused certainty certainty of evidence Clinical effect Clinical research Clinical significance clinical trials Cochrane guidelines Comparisons conducted convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients database development Dexamethasone driven by Effect Evidence evidence of experimental intervention Families GRADE high risk Hydroxychloroquine individual patient data meta-analyses individuals Infection intensive care International Intervention Intervention effects item Juul lack life Lopinavir Lopinavir–ritonavir mechanical ventilation meta-analyses Meta-analysis Network meta-analysis no effect no effects no evidence of nonserious adverse event nonserious adverse events on mechanical ventilation outbreak outcome outcomes participant Participants Patient patient data paucity of data performed Placebo Primary outcomes Quality of life random errors random-effects meta-analyses randomized clinical trial randomized clinical trials rapidly spreading disease rate ratio reduce reduced reducing Remdesivir renal replacement therapy replacement therapy Reporting Research researcher respiratory Respiratory failure review risk risk of bia risk of death risk ratio Ritonavir SARS-CoV-2 searched secondary Secondary outcomes Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single trial single trial randomizing Sophie Spread standard care statistically significant systematic review systematic reviews Treatment treatment for COVID-19 treatment intervention treatment of COVID-19 treatments for COVID-19 treatments of COVID-19 Trial Trial methodology trial randomizing trial sequential analyses trial sequential analysis website with COVID-19
[DOI] 10.1371/journal.pmed.1003293 PMC 바로가기 [Article Type] Research Article

A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial

미분화 결합 조직 질환이 있는 여성의 반복적인 임신 상실을 치료하기 위한 하이드록시클로로퀸 및 저용량 프레드니손의 3군, 다기관, 공개 라벨 무작위 대조 시험: LIFE(LIFE) 시험을 위한 면역억제 요법에 대한 프로토콜

Study Protocol

Published on 2020-09-092022-09-10
Journal: Trials [Category] SARS, 임상,

[키워드] abortion Activation addition Anticoagulant anticoagulation Arm assigned connective tissue connective tissue disease Controlled trial defined disease Efficacy eligible patient evaluate Evidence HCQ Hydroxychloroquine immune Immunosuppressant include induce Inflammation live births low-dose morbidities multicenter Open-label open-label randomized controlled trial outcome Patient patients placental Prednisone Pregnancy Prevent Primary outcome Prognosis progression protocol Randomized controlled trial Randomly Recurrent pregnancy loss Recurrent spontaneous abortion regimen secondary Secondary outcomes spontaneous abortion treat Trial Trial registration Undifferentiated Undifferentiated connective tissue disease Vascular damage women
[DOI] 10.1186/s13063-020-04716-1 PMC 바로가기 [Article Type] Study Protocol

Qingfei Paidu decoction for treating COVID-19 A protocol for a meta-analysis and systematic review of randomized controlled trials

3800

Published on 2020-09-042022-10-30
Journal: Medicine [Category] COVID-19, SARS,

[키워드] acute infectious disease adverse event CBM China Chinese clinical history Clinical symptoms CNKI Cochrane Library conducted Coronavirus disease 2019 COVID-19 data extraction database Decoction disease effective Effectiveness Efficacy and safety English Epidemic evaluated Evidence expressed Fatality rate fixed global public health heterogeneity Infectious disease lack Lung CT mean difference Meta-analysis outbreak outcomes peer-reviewed protocol Qingfei Paidu decoction random effect model Randomized controlled trial RCTs REM Research researcher risk Secondary outcomes SMD systematic review Total Traditional Chinese medicine treating COVID-19 Treatment VIP Web of Science
[DOI] 10.1097/MD.0000000000022040 PMC 바로가기 [Article Type] 3800

Hydroxychloroquine plus personal protective equipment versus standard personal protective equipment alone for the prevention of COVID-19 infections among frontline healthcare workers: the HydrOxychloroquine Prophylaxis Evaluation(HOPE) trial: A structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-08-312022-10-29
Journal: Trials [Category] COVID-19, MERS,

[키워드] 1:1 absolute reduction addition Administered Admission adverse event adverse events all-cause mortality allocation Arm ARMS assigned assumed baseline Bia breast-feeding China clinical Combination Compliance conducted Confirmed COVID-19 infection Contamination COVID-19 COVID-19 infection Date detect dissemination dose ECG element eligible end point enrolled enrolment evaluate evaluate the effect excluded Follow-up frontline healthcare worker greater HCQ HCW HCWs Health personnel healthcare hospital Hospitalization hospitals Hydroxychloroquine ICU India Infection infection rate initiated intensive care Intervention intervention arm invasive ventilation investigator Italy Laboratory Loading dose medication MONITOR Non-invasive number objective Open-label organ support outcome parallel group participant Patient performed Personal protective equipment PPE pregnant Prevent prevention of COVID-19 Primary outcome proportion protocol provided QT prolongation QTc randomisation randomised randomised controlled trial randomization Randomized controlled trial rate of infection readmission receive reduction Registered registry renal replacement therapy reported Research Sample size Secondary outcomes secure Standard Statistical power status stratified Study protocol Treatment Trial two-sided Vasopressor website
[DOI] 10.1186/s13063-020-04679-3 PMC 바로가기 [Article Type] Letter

Acupressure therapy and Liu Zi Jue Qigong for pulmonary function and quality of life in patients with severe novel coronavirus pneumonia (COVID-19): a study protocol for a randomized controlled trial

중증 신종 코로나바이러스 폐렴(COVID-19) 환자의 폐 기능 및 삶의 질을 위한 지압 요법 및 Liu Zi Jue Qigong: 무작위 대조 시험을 위한 연구 프로토콜

Study Protocol

Published on 2020-08-272022-08-13
Journal: Trials [Category] MERS, 임상,

[키워드] 1:1 2019 novel coronavirus activities activity Acupressure Acupressure therapy addition Admission Adverse adverse events analyst assessor-blinded assessment assessments assigned Barthel Index both groups can be used Chinese Chinese Clinical Trial Registry clinical clinical scale clinical scales complementary Controlled trial COVID-19 Daily discharge Dyspnea effective therapy Efficacy evaluate event Evidence evidence of Hospitalization in both group include intervention group Liu Zi Jue Qigong Liu Zi Jue Qigong exercises Medical Research Council Modified Medical Research Council Dyspnea Scale Novel coronavirus parallel-design Patient Patient Health Questionnaire-9 Scale patients with COVID-19 performed Pneumonia poor prognosis Primary outcome Pulmonary function Qigong Qigong exercise Qigong exercises Quality of life Randomized controlled trial randomized trial Randomly receive recorded recruited registry rehabilitation respiratory Respiratory Symptoms Scale safety evaluation scale secondary outcome Secondary outcomes severe COVID-19 severe disease Study protocol supportive care symptomatic TCMR therapy therapy for COVID-19 Traditional Chinese medicine Traditional Chinese medicine rehabilitation Treatment Trial twice a day Two-arm Wuhan Wuhan, China
[DOI] 10.1186/s13063-020-04693-5 PMC 바로가기 [Article Type] Study Protocol

High dose dexamethasone treatment for Acute Respiratory Distress Syndrome secondary to COVID-19: a structured summary of a study protocol for a randomised controlled trial

COVID-19에 따른 급성 호흡곤란 증후군에 대한 고용량 덱사메타손 치료: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2020-08-262022-08-13
Journal: Trials [Category] MERS, 임상,

[키워드] 1:1 active cancer acute respiratory distress acute respiratory distress syndrome Adult patients advance directives Advanced cancer age alpha error anticipated approved ARDS assessment assigned bilateral pulmonary infiltrates Blinding block breast-feeding Buenos Aires capture cardiac disease CEMIC clinical clinical trial code Complete concealed Confirmed COVID-19 COVID-19, Dexamethasone, Acute Respiratory Distress Syndrome, Randomised controlled trial, protocol, Steroids delirium develop Dexamethasone diagnosis of SARS-CoV-2 directive discharge disease dissemination do not resuscitate dose Effectiveness element End-Expiratory Pressure evaluate exclusion criteria Expiratory Pressure explained failure followed by Frequency glucocorticoid Glucocorticoids group hemodynamic High dose HIV infection hypoxemic Hypoxemic respiratory failure ICU Immunosuppression Immunosuppressive agents include inclusion criteria Infection Informed consent intensive care unit International legal guardian Length less Life expectancy local Ethics Committee mechanical ventilation Mortality multicenter muscle weakness Nosocomial infection Nosocomial infections number objective open open label open trial other disease other diseases outcome Palliative care PaO parallel group participant Participation Patient Patient care platform Pneumonia Positive end-expiratory pressure power power of 80% Prednisone pressure Prone position protocol R language random randomised randomised controlled trial randomization Randomized randomized clinical trial receive recruitment Registered renal renal disease respiratory respiratory distress Respiratory distress syndrome Respiratory failure resuscitate order RT-PCR Sample size SARS-COV-2 infection SARS-CoV-2 pneumonia secondary Secondary outcomes secondary to sequence Sequential Organ Failure Assessment severe immunosuppression SOFA Standard deviation status Stratified randomization Study protocol subject Support syndrome table terminal Terminal disease title Treatment treatment groups Trial Trial registration two-tailed alpha error Variation ventilator ventilator-free day Ventilator-free days ventilatory Version viral shedding weakness website women
[DOI] 10.1186/s13063-020-04646-y PMC 바로가기 [Article Type] Letter

Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial

만성 폐쇄성 폐질환의 근육량 개선을 위한 강화 유청 음료: 단일 맹검, 무작위 임상 시험

Research

Published on 2020-08-172022-09-06
Journal: Respiratory Research [Category] Communicable Disease,

[키워드] analyzed Bioelectrical Impedance Analysis Body body composition body protein Cachexia calculated change changes in chronic obstructive Concentration concentrations conducted control group COPD Cytokines Effect effective Efficacy fat-free mass fortified glutathione handgrip strength IL-6 Inflammation Inflammatory cytokine Inflammatory cytokines interleukin Intervention intervention group life Lung diseases Magnesium Malnutrition malondialdehyde muscle mass Muscle strength Necrosis nutritional intervention nutritional supports obstructive pulmonary diseases participant Patient Primary outcome Primary outcomes progression pulmonary disease Quality of life randomized clinical trial randomized trial Result secondary outcome Secondary outcomes serum serum concentrations significant changes in significant decrease significantly single-blind Skeletal muscle suggested Support TNFα Tumor tumor necrosis tumor necrosis factor two groups variables Vitamin Vitamin C was performed were measured whey
[DOI] 10.1186/s12931-020-01466-1 PMC 바로가기 [Article Type] Research

Efficacy and safety of Lianhua Qingwen in the treatment of patients with moderate COVID-19 infection A protocol for systematic review and meta analysis

4900

Published on 2020-08-142022-10-30
Journal: Medicine [Category] COVID-19, MERS,

[키워드] adjusted adverse event Analysis Antiviral baseline Biology calculate carried Chest computed tomography China Chinese clinical decision Clinical symptoms Cochrane Library collaboration control group coronavirus disease Coronavirus disease 2019 correlation COVID-19 infection COVID-2019 database Efficacy Efficacy and safety Egger Endpoint estimates evaluate Evidence forest plot Government heterogeneity identify independent Infrastructure linear regression test Manifestations Medicine Meta-analysis Novel coronavirus patients with COVID-19 patients with moderate Pneumonia positive Primary outcomes protocol provided reported Result risk risk of bia Science secondary outcome Secondary outcomes severe cases systematic review technology Traditional Chinese herbal medicine Treatment Vaccine
[DOI] 10.1097/MD.0000000000021614 PMC 바로가기 [Article Type] 4900