The cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients돼지에서 대사 증후군의 심장 분자 설정은 질병 감수성을 나타내며 환자에서 Covid-19 결과를 악화시키는 메커니즘을 제안합니다.Article Published on 2021-10-052022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] aggregation Analysis animal model Arterial thrombosis association Blood blood test blood tests capture cardiovascular disease cardiovascular diseases change Comorbidity Complement pathway component components computational analysis COVID-19 CVD deregulation develop diabete diabetes disease elevated enriched pathway enzyme exacerbate expressed greater hallmark hallmarks hypertension identity immune response investigated mechanism metabolic syndrome metabolite metabolites metabolomics molecular Myocardial Myocardium obese obesity outcome overexpressed pathophysiology Patient patients patients with COVID-19 PIGS Platelet platelet aggregation pro-inflammatory pro-inflammatory markers Protein proteomics reveal risk risk factor Risk factors RNA methylation susceptibility syndrome Therapeutic approach thrombosis transcriptomics virus viruses while [DOI] 10.1038/s41598-021-99143-w PMC 바로가기 [Article Type] Article
Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage InteractionsSARS-CoV-2-인간 대식세포 상호작용에 대한 타고난 면역 반응 정의Immunology Published on 2021-10-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation activity acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 ARDS characterized chemokine component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm dendritic cells dysregulation end-organ end-organ disease Evidence evidence of expression Host human monocyte human monocyte-derived macrophages IFN immune Infection Inflammation Inflammatory Innate innate immune innate immune response Interaction interferon investigated life-threatening coronavirus disease Macrophage macrophages malfunctions monocyte-macrophage Monocytes mononuclear phagocyte mononuclear phagocytes morbidities pro-inflammatory pro-inflammatory cytokine profile proteomic proteomics receptor respiratory respiratory distress Respiratory distress syndrome response robust SARS-CoV-2 SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus signaling pathways syndrome systemic inflammation the SARS-CoV-2 tissue damage transcriptomic transcriptomics type I interferon Viral viral infection viral replication virion virions while [DOI] 10.3389/fimmu.2021.741502 PMC 바로가기 [Article Type] Immunology
Acute Kidney Injury in Severe COVID-19 Has Similarities to Sepsis-Associated Kidney Injury: A Multi-Omics Study심각한 COVID-19의 급성 신장 손상은 패혈증 관련 신장 손상과 유사합니다: 다중 오믹스 연구Article Published on 2021-10-012022-09-12 Journal: Mayo Clinic proceedings [Category] MERS, 진단, [키워드] Acute kidney injury adaptive age AKI Analysis analyzed antigen-presenting cells Apoptosis autophagy Autopsy cause CD3 CD4 Characteristics coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case Cytometry diagnostic died downregulation endothelial injury evaluated Evidence glomerular highlight histocompatibility complex immune individual individuals with COVID-19 Inflammation Injury interstitial investigation involved kidney less Mayo Clinic mitochondrial mitochondrial dysfunction molecular morphology necroptosis Older oxidative phosphorylation pathology pathway Pathway analysis Pathways performed peritubular peritubular capillary postmortem interval proteomic proteomics Regulatory renal Seven similarity subset T cell T helper cell therapeutic targets tissue transcriptional Transcriptome transcriptomic vascular dysfunction was performed [DOI] 10.1016/j.mayocp.2021.07.001 PMC 바로가기 [Article Type] Article
SGLT2-Inhibition reverts urinary peptide changes associated with severe COVID-19: An in-silico proof-of-principle of proteomics-based drug repurposingSGLT2-억제는 심각한 COVID-19와 관련된 요로 펩티드 변화를 되돌립니다: 프로테오믹스 기반 약물 용도 변경의 인-실리코 증거Article Published on 2021-10-012022-09-11 Journal: Proteomics [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 진단, [키워드] approach change collected COVID-19 COVID-19 severity database dataset diagnostic drug Drug repurposing drug therapies drug treatment drugs Empagliflozin endothelial endothelial damage Germany Hypothesis in urine in vitro in-silico molecular observation participant patients without COVID-19 peptide peptides positive potential benefit potential benefits principle proof protective mechanisms proteome proteomics Randomized reflected Registered reversed selected severe COVID-19 SGLT2 inhibition significant changes in spironolactone Support Therapeutic benefit therapy Treatment trial testing Urine [DOI] 10.1002/pmic.202100160 PMC 바로가기 [Article Type] Article
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation17개의 SARS-CoV-2 단백질의 근위 프로테옴은 항바이러스 신호 전달 및 숙주 번역을 방해합니다.Research Article Published on 2021-10-012022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Activation antiviral signaling association atlas Card cleavage complex coronavirus Coronaviruses COVID-19 severity CWC22 database Factor FANCD2 Fluorescence functional Host host protein host proteins human cell human protein identify IFNB1 Impact inhibited inhibitor innate immune interferon signaling M protein MAVS membranes nsp1 nsp5 ORF6 Pathogenesis pathogenic coronavirus pathogenic mechanism pathogenic mechanisms pathogenicity peptide peptide sequences promote promoter protease Protein protein translation Proteins proteome proteomics proximal public health threat regulator Regulatory resource RIG-I SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral sequence Signaling subcellular target the SARS-CoV-2 translation translation initiation Transport TRIM4 variant Viral Viral protein Viral proteins [DOI] 10.1371/journal.ppat.1009412 PMC 바로가기 [Article Type] Research Article
Uncovering the Depths of the Human Proteome: Antibody-based Technologies for Ultrasensitive Multiplexed Protein Detection and QuantificationReview article Published on 2021-09-282022-10-05 Journal: Molecular & Cellular Proteomics : MCP [Category] 비임상, [키워드] antibody array antibody microarray aptamer biofluid Biomarker Comparisons complement Concentration cross talk Depth detection disadvantage disease drug target discovery Human immunoassays knowledge mechanisms multiplex plasma Probing Protein Proteins proteome proteomics proximity extension assay quantification recent researcher single-molecule array technology technology advances technology comparison tissue [DOI] 10.1016/j.mcpro.2021.100155 [Article Type] Review article
Identification of Unique Peptides for SARS-CoV-2 Diagnostics and Vaccine Development by an In Silico Proteomics ApproachIn Silico Proteomics 접근법에 의한 SARS-CoV-2 진단 및 백신 개발을 위한 고유 펩티드 식별Immunology Published on 2021-09-242022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료법, [키워드] A549 cell line A549 cell lines acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allergens Analysis Antigen antigenic peptide antigenic peptides antigenicity approach B-cell binding affinity cell line complexes coronavirus COVID-19 COVID-19 diagnosis COVID-19 patients COVID-19 vaccines crystal structure crystal structures develop development diagnostic diagnostic peptides diagnostics disorders docking effort evaluated Evolution examined help histocompatibility complex human proteins human saliva identification immunogenicity in-silico Initially major histocompatibility complex MHC Microbiome paratopes pathogenic peptide peptides Polymorphisms proteomic proteomics respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2-specific antibodies screened selected sequence similarity severe acute respiratory syndrome Coronavirus specific antibodies T-cell receptor TCR tested Toxicity Treatment unique utility Viral virus strain virus strains [DOI] 10.3389/fimmu.2021.725240 PMC 바로가기 [Article Type] Immunology
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19자체 유지 IL-8 루프는 심각한 COVID-19에서 전혈전성 호중구 표현형을 유도합니다Research Article Published on 2021-09-222022-09-12 Journal: JCI Insight [Category] SARS, 진단, [키워드] activated Activation acute respiratory distress acute respiratory distress syndrome Analysis ARDS attenuate autocrine cascade characterized Coagulation complement Complement cascade contribute contributing to coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical CXCL8 Cytokines Defense degranulation dissect dysregulation functional highlighting identify IL-8 immune response immune responses immunopathology in vitro in vivo Infection initiate interfere intrinsic Lung injury mechanism mice NET NETosis neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils Pathogens Patient patients phenotype positive feedback positive feedback loop procoagulant progression proinflammatory proteomics prothrombotic pulmonary microthrombosis recent reduce respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection self-damage severe acute respiratory distress syndrome severe COVID-19 severe SARS severe SARS-CoV-2 Signaling syndrome systemic targeting therapeutic target transcriptomic transition TRAP Vascular Biology vicious cycle [DOI] 10.1172/jci.insight.150862 PMC 바로가기 [Article Type] Research Article
Discovery Proteomics for COVID-19: Where We Are NowReview Published on 2021-09-222023-06-15 Journal: Journal of Proteome Research [Category] MERS, SARS, [키워드] biofluids Biomarkers COVID-19 mass spectrometry plasma proteomics SARS-CoV-2 [DOI] 10.1021/acs.jproteome.1c00475 PMC 바로가기 [Article Type] Review
Analysing the impact of the two most common SARS-CoV-2 nucleocapsid protein variants on interactions with membrane protein in silicoShort Communications Published on 2021-09-202022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] acute respiratory syndrome analysed Analysing coronavirus function globe in silico Interaction less M protein membrane protein mutant Mutation N protein N-M protein interactions nucleocapsid protein predicted Protein proteomics reported Research Salt Bridge SARS-CoV-2 SARS-CoV-2 nucleocapsid sensitivity significant difference supplementary material temperature the SARS-CoV-2 variant virion wild type [DOI] 10.1186/s43141-021-00233-z PMC 바로가기 [Article Type] Short Communications