SARS-CoV-2 spike – Page 28 – Communicable Diseases Research

Comirnaty-Elicited and Convalescent Sera Recognize Different Spike Epitopes

Article

Published on 2021-12-012022-10-28
Journal: Vaccines [Category] COVID-19,

BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2

Research

Published on 2021-11-302022-10-05
Journal: Nature Immunology [Category] SARS, 변종, 치료제,

Detection of cross-reactive immunoglobulin A against the severe acute respiratory syndrome-coronavirus-2 spike 1 subunit in saliva

중증 급성 호흡기 증후군-코로나 바이러스 -2 스파이크에 대한 교차 반응성 면역 글로불린 A의 검출 1 타액의 서브 유닛

Research Article

Published on 2021-11-232022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술,

[키워드] age analyzed angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 binding Biotin blood sample Blood samples breast milk Chain Reaction correlated cross-react cross-reaction cross-reactive cross-reactivity dental dentist dentists detection determined by enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay help IgG and IgM Immunity immunochromatography Immunoglobulin immunoglobulin A individual Infection involved men mucosal surfaces Mucus Patient patients PCR PCR-negative polymerase chain polymerase chain reaction Prevent proportion Protein provide purified reaction receptor Receptor-binding domain reported Saliva saliva samples SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secretory immunoglobulin A SIgA significantly lower Spike protein subunit suppress the receptor-binding domain university virus was determined women
[DOI] 10.1371/journal.pone.0249979 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients

SARS-CoV-2 재조합 단백질은 COVID-19 회복기 환자의 샘플에서 뚜렷한 세포 및 체액 면역 반응 프로필을 자극합니다

Original Article

Published on 2021-11-232022-09-10
Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens blood sample Blood samples CD3+ cellular Cellular immune response cellular immune responses cellular immunity chemiluminescence Contact contact with convalescent convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient Determination domain Donor ELISA ELISAs examined groups humoral humoral immune response Humoral response IFN-γ IgG antibodies IgG antibody Immune profile immune response immune responses Immunity individual individuals investigated Lymphocytes membrane nucleocapsid overlapping Patient peptide peptide pool peptide pools peptides pool profile Proteins RBD Receptor-binding domain Recombinant protein recombinant proteins regions respiratory S1/S2 SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike sequence serum serum IgG antibodies serum IgG antibody severe acute respiratory syndrome Coronavirus shown stimulate Stimulation T cell T cells T lymphocyte T lymphocytes volunteers
[DOI] 10.6061/clinics/2021/e3548 PMC 바로가기 [Article Type] Original Article

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

TMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다

Research Article

Published on 2021-11-222022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses
[DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article

Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases

중증, 중등도 및 경증 COVID-19 사례의 회복기 샘플에서 SARS-CoV-2 감염의 혈청학적 바이오마커 분석

Comparative Study

Published on 2021-11-192022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료법,

[키워드] acute respiratory syndrome addition antibodies antibody Antibody binding antibody levels Antibody Response Antibody responses Antibody Units Antigen Asymptomatic asymptomatic infection average BAU binding antibodies binding antibody binding antibody units Biomarker Biomarkers candidate Clinical severity convalescent sera correlated correlates of protection COVID-19 COVID-19 disease COVID-19 immune response COVID-19 pandemic COVID-19 patients Electroporation ELISA epidemiological studies Epidemiological study flow cytometry HCW healthcare worker Humoral immunity identify IgA IgM increasingly International international standard international units Lateral flow test microneutralisation test Mild mild or asymptomatic infections multiplex neutralisation neutralisation assay Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses nucleocapsid positive correlation Prevalence protection pseudotyped RBD Re-infection respiratory Sample SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2-specific IgG Serological biomarkers SEROLOGICAL STUDY seronegative seropositive Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severe COVID-19 patient severe COVID-19 patients severity significantly higher spike statistically to define unit vaccination Vaccine vaccine trial variants of concern Virus neutralisation virus neutralisation assay virus neutralising antibody VoC were expressed WHO WHO guideline WHO International Standard World Health Organisation
[DOI] 10.3389/fimmu.2021.748291 PMC 바로가기 [Article Type] Comparative Study

Phosphatidylserine receptors enhance SARS-CoV-2 infection

포스파티딜세린 수용체는 SARS-CoV-2 감염을 강화합니다

Research Article

Published on 2021-11-192022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 치료기술,

[키워드] Ablation ACE2 adhere airway apoptotic apoptotic bodies bemcentinib Betacoronavirus binding cathepsin Cell cell line cell surface receptor cell surface receptors cells contrary coronavirus correlated detect detectable Endosomal acidification ENhance entry of SARS-CoV-2 evaluated Evidence Express expressed expression facilitate facilitated Host human lung identify Infection inhibit SARS-CoV-2 inhibited inhibitor inhibitors Interaction internalization knockout Liposome mechanism MHV mouse hepatitis mouse hepatitis virus murine mutant observation pandemic coronavirus Phosphatidylcholine Phosphatidylserine pseudovirion purified receptor receptors reduce reduced SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 virions Signaling small molecule small molecule inhibitor Small molecule inhibitors Support TAM the SARS-CoV-2 therapeutic potential Vero E6 Vero E6 cell VERO E6 cells virion virus virus entry virus infection viruses
[DOI] 10.1371/journal.ppat.1009743 PMC 바로가기 [Article Type] Research Article

Site-Specific Glycosylation Patterns of the SARS-CoV-2 Spike Protein Derived From Recombinant Protein and Viral WA1 and D614G Strains

Chemistry

Published on 2021-11-192022-10-31
Journal: Frontiers in Chemistry [Category] COVID-19,

[키워드] ACE2 receptor Analysis analyzed Cell cell substrate characterized complex core Critical D614G D614G variant defined domain downstream Eclipse Efficiency glycan glycan shield glycans glycosylated glycosylation glycosylation pattern HEK293 high-mannose Host Host–pathogen interaction hydrophilic in viral Infection Interaction less Local microheterogeneity monomer Mutation N-glycan N-glycosylation N-glycosylation site O-glycosylation Orbitrap pattern predicted produced Protein RBD recent recombinant Recombinant protein reported reveal S1 and S2 S1 domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike Spike protein Spike proteins strain substrate the SARS-CoV-2 Vero Vero cells Vero E6 virus WA1 WA1 strain
[DOI] 10.3389/fchem.2021.767448 PMC 바로가기 [Article Type] Chemistry

Recombinant production of a functional SARS-CoV-2 spike receptor binding domain in the green algae Chlamydomonas reinhardtii

Research Article

Published on 2021-11-182022-10-28
Journal: PLoS ONE [Category] COVID-19,

Development of COVID-19 vaccine using a dual Toll-like receptor ligand liposome adjuvant

Brief Communication

Published on 2021-11-182022-10-04
Journal: NPJ Vaccines [Category] 진단,

[키워드] Adaptive immunity adjuvants COVID-19 vaccine development elicited IgA immunization Ligand Liposome lung Lung injury mice neutralizing antibody receptor robust SARS-CoV-2 spike subunit systemic and local TLR Vaccine virus
[DOI] 10.1038/s41541-021-00399-0 PMC 바로가기 [Article Type] Brief Communication