Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico ScreeningMicrobiology Published on 2021-07-202022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] absence acute respiratory syndrome Antiviral antiviral activities approach approved drug AutoDock binding free energy clinical settings clinical trial combat combinatorial therapy coronavirus COVID-19 curative treatment Dexamethasone docking domain drug Drug repurposing effective Effectiveness ExoN proofreading exonuclease exonuclease inhibitor identify in silico in vitro inhibitor inhibitors Interaction MD simulation molecular molecular docking molecular docking and MD simulation nsp14 nucleoside nucleoside analog Prophylactic RdRP RdRp inhibitor RNA RNA-dependent RNA polymerase SARS-CoV-2 screened Screening shown solvent Strategy the disease therapy treat Treatment [DOI] 10.3389/fmicb.2021.647693 PMC 바로가기 [Article Type] Microbiology
Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2Review Published on 2021-07-202023-07-01 Journal: Journal of controlled release : official journal o [Category] SARS, [키워드] COVID-19 drug delivery Drug repurposing drug targeting inhalation therapy nanomedicine [DOI] 10.1016/j.jconrel.2021.07.028 PMC 바로가기 [Article Type] Review
Modulating the host immune response to fight against COVID-19: Where are we in 2021?Covid-19와의 싸움을위한 숙주 면역 반응 조절 : 2021 년 우리는 어디에 있습니까?Editorial Published on 2021-07-052022-09-10 Journal: Virulence [Category] SARS, 신약개발, 치료제, [키워드] coronavirus COVID-19 Drug repurposing Host immune response immune system immunology immunomodulation pharmacotherapy SARS-CoV-2 [DOI] 10.1080/21505594.2021.1943275 PMC 바로가기 [Article Type] Editorial
SAVER: sodium valproate for the epigenetic reprogramming of high-risk oral epithelial dysplasia—a phase II randomised control trial study protocolSaver : 고위험 경구 상피의 후성 재 프로그래밍을위한 나트륨 valproate-2 상 무작위 대조 시험 연구 프로토콜Study Protocol Published on 2021-07-052022-09-01 Journal: Trials [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 진단, [키워드] acceptability adverse effects Blood blood sample Blood samples cancer development Chemoprevention childbearing potential clinical collected Compliance Diagnosis Drug repurposing dysplasia Effect Endpoint Epigenetic Epigenetic reprogramming epithelial European Evidence evidence of excluded feasibility GRADE IIb include lead lesion size malignancy management medication notable observation Open-label oral cancer Oral epithelial dysplasia outcome Patient Perception preliminary evidence Primary outcome protective mechanism provide randomisation randomised randomised controlled trial recruited recruitment reduced risk reduction in regions Registered risk secondary care sodium Sodium valproate Study protocol subsequent supplementary material surgery surgical resection Surveillance targets teratogenic Trial Trial registration Valproate [DOI] 10.1186/s13063-021-05373-8 PMC 바로가기 [Article Type] Study Protocol
Heparin: A simplistic repurposing to prevent SARS-CoV-2 transmission in light of its in-vitro nanomolar efficacyResearch article Published on 2021-07-012022-10-05 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, [키워드] ACE2 ACE2 binding ACE2angiotensin-converting enzyme 2 Analysis angiotensin-converting enzyme 2 Anti-SARS-CoV-2 Activity antiviral activity Antiviral compound available data CDCCenters for Disease Control and Prevention Cell Centers for Disease Control and Prevention Complete Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 disrupting drug Drug repurposing Eagle's Minimum Essential Medium Efficacy EMEMEagle's Minimum Essential Medium epithelia evaluated FBSfetal bovine serum FDA FDAU.S. Food and Drug Administration fetal bovine serum high throughput virtual screening HTVShigh throughput virtual screening IC50 identity IDidentity in-silico In-vitro include independent indicated interact Interaction LMWHlow-molecular-weight heparin Low-molecular-weight heparin mutant nasal Neuropilin-1 Novel coronavirus NRP1neuropilin-1 P/Spen strep pandemic Pathogens pathology PBSphosphate-buffered saline PDBProtein Data Bank pen strep phosphate-buffered saline potential transmission Prevent Protein Data Bank RBDReceptor Binding Domain Receptor binding domain reducing reported SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 Spike protein Spike proteins Support thrombotic event TMPRSS2transmembrane serine protease 2 transmembrane serine protease 2 Transmission treat U.S. Food and Drug Administration UFHunfractionated heparin unfractionated heparin United States variant viral entry Viremia Virtual screening virus assay with COVID-19 [DOI] 10.1016/j.ijbiomac.2021.04.148 [Article Type] Research article
Modern computational intelligence based drug repurposing for diabetes epidemicReview article Published on 2021-07-012022-10-05 Journal: Diabetes & metabolic syndrome [Category] 신약개발, [키워드] analyzed artificial intelligence berberine Candidates Clobetasol diabete diabetes Diabetic Diacerein drug Drug repurposing Efficiency Epidemic highlighting IMPROVE information methazolamide Modern computational intelligence models Molecular property diagnostic suite diabetes mellitus (MPDSDM) objective recent Result significantly Toxicity [DOI] 10.1016/j.dsx.2021.06.017 [Article Type] Review article
Interaction of selected terpenoids with two SARS-CoV-2 key therapeutic targets: An in silico study through molecular docking and dynamics simulations두 개의 SARS-CoV-2 주요 치료 표적과 선택된 테르페노이드의 상호 작용: 분자 도킹 및 역학 시뮬레이션을 통한 in silico 연구Article Published on 2021-07-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 신약개발, [키워드] 3CL hydrolase ACE2 receptor Amino acid amino acid residue amino acid residues Analysis Antiviral approved drug binding catalytic dyad caused Complete Compound Computational approaches confirmation Contact contact with contrary Course COVID-19 disease docking docking score Drug repurposing effective enzyme growth hydrolase in silico in vitro in vivo inhibit inhibitors inhibitors of SARS-CoV-2 inhibitory Interaction interfere lack Limonoids molecular molecular docking molecular dynamics Molecular dynamics simulation MPro outbreak pharmacokinetic predicted profiles protease Protein provided RBD SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 replication selected spike Spike protein terpenoids the spike protein therapeutic therapeutic target [DOI] 10.1016/j.compbiomed.2021.104538 PMC 바로가기 [Article Type] Article
Detection of Binding Sites on SARS-CoV-2 Spike Protein Receptor-Binding Domain by Molecular Dynamics Simulations in Mixed Solvents혼합 용매의 분자 역학 시뮬레이션을 통한 SARS-CoV-2 스파이크 단백질 수용체 결합 도메인의 결합 부위 검출Article Published on 2021-07-012022-09-11 Journal: IEEE/ACM transactions on computational biology and [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] accelerate accelerated ACE2 ACE2 binding ACE2 receptor addition angiotensin antibody attachment binding site Compound described detection domain Drug discovery Drug repurposing Dynamics effective drug effective drugs finding identify inhibit inhibitor insight Interaction molecular dynamics Molecular dynamics simulation molecular dynamics simulations observation offer pathogen Prevent probe Protein protocol RBD RBD-ACE2 receptor S protein SARS-CoV-2 SARS-COV-2 infection Simulation Site small molecule Small molecules solvent spike suggested the disease the S protein viral entry Virtual screening [DOI] 10.1109/TCBB.2021.3076259 PMC 바로가기 [Article Type] Article
COVID-19 Management at IHU Méditerranée Infection: A One-Year ExperienceArticle Published on 2021-06-292022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] adaptation analyzed autonomy in decision-making Care case fatality ratio Cell culture CFR clinical care contagious Continuous COVID-19 COVID-19 outbreak Diagnosis diagnostic disease Drug repurposing EKG Epidemic experience Facebook feature France Genetic variant Genome hospitalized patient inoculated isolates leadership low dose management Marseille nasopharyngeal sample Outbreaks outcome Outpatient pandemic Patient patients with COVID-19 PCR test performed positive preparedness provided rerouting of tests Research returned scanner serology the disease unrestricted access to care with COVID-19 [DOI] 10.3390/jcm10132881 PMC 바로가기 [Article Type] Article
Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19Pharmacology Published on 2021-06-242022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] adjuvant Can COVID-19 drug Drug repurposing immunomodulators Infection Inflammation mucolytic serratiopeptidase [DOI] 10.3389/fphar.2021.603997 PMC 바로가기 [Article Type] Pharmacology