Implementation Science to Respond to the COVID-19 PandemicPublic Health Published on 2020-09-022022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, [키워드] Analysis approach contribute COVID-19 COVID-19 pandemic dissemination ENhance Evidence example expand heterogeneous identify implementation Implementation science Local National Novel coronavirus penetration Personal protective equipment PPE public health Public health response qualitative data responses SARS-CoV-2 Science social distancing structures [DOI] 10.3389/fpubh.2020.00462 PMC 바로가기 [Article Type] Public Health
Signal amplification by reversible exchange for COVID-19 antiviral drug candidatesArticle Published on 2020-08-312022-10-04 Journal: Scientific Reports [Category] MERS, 치료법, 치료제, [키워드] amplification Analytical chemistry antiviral drug candidate carried Clinical treatment Coronavirus pneumonia COVID-19 dependent on Diagnosis disease drug drug candidate Favipiravir feature Hydroxychloroquine labeling Medical and clinical diagnostics molecular NMR spectroscopy nuclear nuclei Perspective Research signal structures tested therapeutic transfer Treatment Trial [DOI] 10.1038/s41598-020-71282-6 PMC 바로가기 [Article Type] Article
Protocol: Leveraging a demographic and health surveillance system for Covid-19 Surveillance in rural KwaZulu-NatalStudy Protocol Published on 2020-08-252022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] affecting Care Cohort collected data conducted coronavirus disease COVID-19 Critical Disease surveillance effort Epidemic Epidemics Epidemiology Health Health and Demographic Surveillance System HIV individual Intervention lack Local NPI outbreak pandemic Population positive Prevalence protocol Questionnaires resources risk Screening South Africa structures Support Surveillance the epidemic Tuberculosis unique [DOI] 10.12688/wellcomeopenres.15949.2 PMC 바로가기 [Article Type] Study Protocol
Progress in Developing Inhibitors of SARS-CoV-2 3C-Like ProteaseReview Published on 2020-08-182022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 3CL pro acute respiratory syndrome adopted Antiviral antivirals applied caused cleavage cleaving coronavirus Coronavirus disease 2019 COVID-19 Developing drug design Drug discovery drug target ENCODE enzyme feasibility functional Genome Health High-resolution Infection inhibitor inhibitors M pro nonstructural proteins pandemic polyprotein Prevent processed Progress protease Protease inhibitor Proteases Protein protein structures Proteins SARS-CoV-2 Spread structures therapeutic option Vaccine viral genome viral outbreak Viral protein viral replication virus World Health Organization [DOI] 10.3390/microorganisms8081250 PMC 바로가기 [Article Type] Review
Structure-Based Drug Design of an Inhibitor of the SARS-CoV-2 (COVID-19) Main Protease Using Free Software: A Tutorial for Students and Scientistspreprint Published on 2020-08-122022-10-31 Journal: ChemRxiv [Category] COVID-19, [키워드] AutoDock coronavirus COVID-19 disseminate drug drug candidate drug design experimental validation Free help homologous information inhibitor Interaction M pro modify molecular docking pandemic Pandemics peptide Peptide inhibitor protease provide SARS Coronavirus SARS-CoV SARS-CoV M SARS-CoV-2 scientist structure-based design structures student supplementary material the SARS-CoV-2 tutorial UCSF Chimera X-ray X-ray crystallographic structure [DOI] 10.26434/chemrxiv.12791954 PMC 바로가기 [Article Type] preprint
Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune EvasionArticle Published on 2020-07-282022-10-28 Journal: Viruses [Category] COVID-19, [키워드] alphacoronavirus alphacoronavirus nsp1 Analysis Basis Betacoronavirus Biological biological function Cell cell cycle cell cycle genes Cellular immune response characterized composed conserved creating crystal structure experiment full-length Host host cell host protein host proteins IFN IFN-I immune Infectious disease inhibit inhibiting inhibitory effect interfere interferon mammalian cell mechanism PEDV Phosphorylation proliferation Protein regulate regulated Regulatory Renilla luciferase RNA sequence RNA sequencing selected Seven significantly structure-function structures subtype TGEV treated Viral virulence virus western blotting β-CoV β-CoVs [DOI] 10.3390/v12080812 PMC 바로가기 [Article Type] Article
Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical TrialsReview Published on 2020-07-232022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome block caused Clathrin-mediated endocytosis clinical clinical trial clinical trials combating coronavirus Coronavirus-2 COVID-19 described disease early stage effective endocytosis ENhance enzyme facilitate Health care system Host host protein include Infection lack life macromolecule mechanism mechanisms monoclonal antibodies pandemic polypeptides Potential presenting Prevent protease PROTECT reported researcher SARS-CoV-2 serine 2 small molecule Spike protein Stage structures sulfated polysaccharides target Therapeutics TMPRSS2 transmembrane treat Vaccine viral entry viral fusion viral infection viral life cycle viral spike protein [DOI] 10.3390/ijms21155224 PMC 바로가기 [Article Type] Review
Consolidation in a crisis: Patterns of international collaboration in early COVID-19 researchResearch Article Published on 2020-07-212022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] accelerate activity addition article catastrophic China coronavirus country COVID-19 COVID-19 pandemic COVID-19 research implication International involved loci pandemic pandemic era pattern Policy produced producing question raise Research structures the United State The United States United Kingdom United State [DOI] 10.1371/journal.pone.0236307 PMC 바로가기 [Article Type] Research Article
COVID-19 vaccine development and a potential nanomaterial path forward Reviews Published on 2020-07-152022-10-05 Journal: Nature nanotechnology [Category] SARS, 임상, [키워드] adjuvants Antigen approach benefit clinical trial coronavirus COVID-19 pandemic COVID-19 vaccine development distribution genome sequence highlight inactivated Incubation period lack Lipid nanoparticles mitigate mRNA vaccine Nanotechnology nCoV Pandemics Prevalence Prophylaxis Protein SARS-CoV-2 structures Subunit vaccine Treatment Vaccine vaccine candidate Vaccine design vaccine platform Vaccines viral strains [DOI] 10.1038/s41565-020-0737-y [Article Type] Reviews
In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their LifecyclesMicrobiology Published on 2020-07-032022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3′UTR acid binding Bioinformatic coronavirus determine evaluate Evidence G-quadruplex Genome genomic RNA genomic sequence Human human protein Including indicate inverted repeats loci mechanism MERS-CoV molecular motif mRNA Nidovirale notable nucleic acid nucleotides Regulation Regulatory RNA role SARS-CoV SARS-CoV-2 SARS-CoV-2 RNA sequenced Structure structures [DOI] 10.3389/fmicb.2020.01583 PMC 바로가기 [Article Type] Microbiology