Adaptive immune response – Page 3 – Communicable Diseases Research

Molecular mechanisms involved in pathogenicity of SARS-CoV-2: Immune evasion and implications for therapeutic strategies

Article

Published on 2022-09-012022-11-16
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종,

Humoral and adaptive immune responses to the SARS-CoV-2 vaccine

Article

Published on 2022-09-012022-11-15
Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단,

A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial – implications for therapeutic immune modulation

Research article

Published on 2022-08-182022-10-05
Journal: EClinicalMedicine [Category] 바이오마커, 변종, 임상,

[키워드] 1:1 Activation Adaptive immune response addition adverse event ARCADIA assigned AZD1656 Clinical improvement clinical trial Complete COVID-19 cytokine Czech Republic Day death decrease diabetes diabetic patient diabetic patients dose double-blind duration of hospitalisation Efficacy Excalibur False positive finding Full Analysis Set funding Glucokinase activator group homeostatic hospital hospital discharge hospitalised identify immune Immune cell immune modulation immune response Immunochemistry immunomodulatory effect Immunophenotyping implication indicated Innovation investigated involved less Medicine multicentre nine no difference Patient phase Phase 2 Placebo placebo-controlled placebo-controlled clinical trial primary analysis primary endpoint pro-inflammatory randomised Randomly receive recruited reduction in Registered regulatory T cells required risk Romania SARS-CoV-2 screened statistically significant difference suggested Tablet the placebo group therapeutic therapeutic effect treated Treatment treatment allocation Tregs Trial usual care with COVID-19
[DOI] 10.1016/j.eclinm.2022.101604 [Article Type] Research article

Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling

푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다

Article

Published on 2022-08-102022-09-11
Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution virus virus entry virus spread
[DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article

Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapies

B 세포 고갈 요법을받는 다발성 경화증 환자에서 COVID-19 예방 접종에 대한 강력한 T 세포 활성화

Article

Published on 2022-08-052022-09-11
Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response Adaptive immunity analyzed anti-CD20 anti-CD20 therapy antibodies antibody production B-cell binding blocking activity BNT162b2 Cellular immune response cellular response Cohort competent Complication condition controls coronavirus COVID-19 COVID-19 vaccination depleting disease driven by form forms hACE2 healthy control humoral Humoral and cellular responses IFNγ IgG antibodies IgG antibody IL-2 immunocompromised individuals Immunotherapy implication individual individuals Infection investigation mRNA mRNA-1273 mRNA-based mRNA-based vaccine multiple sclerosis no difference Ocrelizumab Patient patients proliferation RBD receiving Receptor binding domain recognizing reduced regimen relapsing respiratory rituximab SARS-CoV-2 Seroconversion seroconversion rate severe acute respiratory syndrome Coronavirus significantly significantly higher Spike protein Strong strong T-cell susceptible T-cell T-cell activation T-cell Response therapy vaccination Vaccine design virus infection
[DOI] 10.3389/fimmu.2022.926318 PMC 바로가기 [Article Type] Article

Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond

바이러스 감염 및 전신 염증: COVID-19 및 그 이후에서 배운 교훈

Review

Published on 2022-07-142022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 치료제,

[키워드] Adaptive immune response addition Antiviral Avian Influenza COVID-19 disease Effectiveness etiological agent facilitate high mortality highlight highly pathogenic highly pathogenic avian influenza human infection human infections immune immune responses immunomodulatory include Infection Inflammatory responses Influenza Influenza virus influenza viruses interferon lesson Local mechanism organ organ-specific pandemic Perturbation Replication respiratory respiratory infections responses responsible SARS-CoV-2 severe disease similarity systemic systemic inflammation target organ therapeutic strategy viral infection viral replication viral spread virus zoonotic
[DOI] 10.3390/cells11142198 PMC 바로가기 [Article Type] Review

Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children

상기도 유전자 발현은 소아에서 SARS-CoV-2에 대한 보다 강력한 적응 면역 반응을 보여줍니다

Article

Published on 2022-07-082022-09-11
Journal: Nature Communications [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단,

Nasopharyngeal Bacterial Microbiota Composition and SARS-CoV-2 IgG Antibody Maintenance in Asymptomatic/Paucisymptomatic Subjects

무증상/무증상 피험자의 비인두 세균성 미생물총 구성 및 SARS-CoV-2 IgG 항체 유지 관리

Article

Published on 2022-07-062022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Analysis anti-RBD antibody Asymptomatic Asymptomatic carriers Bacterial best cause characterized condition coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 enrolment Evidence IgG antibody immune response immunoglobulins Immunological memory Infection influence investigated knowledge Lung injury maintenance mechanism microbiota multi-organ failure nasopharyngeal nasopharyngeal bacterial microbiota. Nasopharyngeal swab Odds ratio performed positive positive serology predict Regulation respiratory respiratory infection respiratory infections SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 infections SARS-CoV-2 RNA serum severe acute respiratory syndrome Coronavirus severity subject tested UNICORN Viral viral entry viral infections
[DOI] 10.3389/fcimb.2022.882302 PMC 바로가기 [Article Type] Article

Avidity in antibody effector functions and biotherapeutic drug design

Reviews

Published on 2022-07-052022-10-05
Journal: Nature Reviews Drug Discovery [Category] 변종, 유전자 메커니즘, 치료제,

Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine

나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다

Article

Published on 2022-07-012022-09-11
Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants
[DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article