Heterogeneous groups of alveolar type II cells in lung homeostasis and repair폐 항상성 및 복구에서 폐포 유형 II 세포의 이종 그룹Review Published on 2020-12-012022-09-11 Journal: American journal of physiology. Cell physiology [Category] SARS, 유전자 메커니즘, [키워드] allergens alveolar alveolar epithelium Alveolar Type II alveoli AT2 cause Cell cells coronavirus disease Coronavirus disease 2019 COVID-19 differentiation finding function group heterogeneity homeostasis Injury integrity Lineage lung Lung disease lung; maintain marker gene mechanism pandemic Pathogens pathological conditions progenitor repair revelation scRNA-seq Single-cell RNA-sequencing stem cell stem cells subpopulation target targets tissue type II cells virus [DOI] 10.1152/ajpcell.00341.2020 PMC 바로가기 [Article Type] Review
Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19Article Published on 2020-10-202022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] airway alveolar epithelium analyzed Cell cell type Consequences COVID-19 death rate demonstrated Express implication Infection Lower respiratory tract lung epithelial resulting RNA-seq dataset SARS-CoV-2 SARS-CoV-2 entry factor SARS-CoV-2 entry factors SARS-COV-2 infection severe respiratory failure severity stem cell transcriptomics viral infection [DOI] 10.1038/s41598-020-74598-5 PMC 바로가기 [Article Type] Article
Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosisReview Published on 2020-10-142022-10-30 Journal: Molecular Medicine [Category] Coronavirus, MERS, SARS, [키워드] Activation Alter alveolar cells alveolar epithelium arise capillary Cell cellular COVID-19 patient Critical cytoskeletal Effect endothelial cells Epigenetic epithelial epithelial cells Extracellular matrix fibroblast fibroblasts fibrosis Gas exchange generate Injury Local Lung fibrosis Macrophage Mast cells mechanical stress Mechanical stress niche mechanical ventilation Mild pathology pulmonary pulmonary fibrosis receive Regulation repeated severe hypoxemia stages stem cells subject subsequent Supportive treatment tissue variety vascular permeability [DOI] 10.1186/s10020-020-00223-w PMC 바로가기 [Article Type] Review
The Potential Role of Coagulation Factor Xa in the Pathophysiology of COVID-19: A Role for Anticoagulants as Multimodal Therapeutic AgentsReview Article Published on 2020-10-072022-10-29 Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19, [키워드] Activation agent alveolar epithelium Anticoagulants cardiac myocytes cardiopulmonary disease Cell cleavage Coagulation conditions coronavirus COVID-19 expressed Factor X factor Xa fibrosis high-risk patient increased risk Inflammation inhibitor liver Local macrophages observation pathophysiology Patient patients Potential produced Prophylactic resulting role SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection serine protease severe COVID-19 shown Spike protein therapeutic Therapeutic treatment viral infectivity Viral load with COVID-19 [DOI] 10.1055/s-0040-1718415 PMC 바로가기 [Article Type] Review Article
Acute Ischemic and Hemorrhagic Stroke in COVID-19: Mounting EvidenceNeurology Published on 2020-08-312022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome alveolar epithelium angiotensin-converting enzyme 2 binding blood vessel case sery caused clinical evidence co-morbidity Comorbidities Complication complication of COVID-19 Coronavirus-2 COVID-19 COVID-19 patients COVID-19 positive patient diagnosed hospital Hospital stay incidence Infection Interaction Intracerebral hemorrhage Ischemic life-threatening mechanism Mortality Mounting novel coronavirus disease observation Patient physician receptor responsible Risk factors SARS-CoV-2 stroke the patient threshold Vascular endothelium weakness [DOI] 10.7759/cureus.10157 PMC 바로가기 [Article Type] Neurology
The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlationOriginal Article Published on 2020-06-302022-10-29 Journal: Virchows Archiv [Category] COVID-19, SARS, [키워드] accompanied alveolar epithelium Autopsy autopsy study Capillaritis caused characterized coronavirus disease correlation COVID-19 death Diffuse alveolar damage disease disease course Disseminated intravascular coagulation early-onset Endothelial cell Evolution fatal COVID-19 fibroblast IL-1beta IL-6 Infarction intra-alveolar invasive therapies laboratory feature Laboratory features Liver damage lung Lung pathology Microthrombosis multi-organ failure neutrophilic Organizing pneumonia Pandemia patients Pneumocytes pro-inflammatory cytokine storm proliferation Pulmonary pathology RNA Stage stages supplementary material thrombosis thrombotic vessels virus particle [DOI] 10.1007/s00428-020-02881-x PMC 바로가기 [Article Type] Original Article
Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic ValueReview Published on 2017-08-012022-10-06 Journal: American Journal of Respiratory and Critical Care [Category] 진단, [키워드] acute lung injury acute respiratory distress adipose alveolar epithelium alveolar fluid clearance antiinflammatory antimicrobial effect ARDS assays Biology Bone marrow causes Cell clinical trial Clinical use conditioned media Effect Efficacy Endothelium ENhance Factor Factors heterogeneous Hyperinflammatory lung Lung injury Mesenchymal stromal cells Microvesicles MSC MSCs paracrine patients with ARDS phagocytosis phase phase 1 trial Potential preclinical studies Pulmonary edema respiratory Serious Adverse Events Support syndrome therapeutic therapeutic potential therapy tissue transfer umbilical up-regulating value Year [DOI] 10.1164/rccm.201701-0107CP PMC 바로가기 [Article Type] Review
Viral Pathogens and Acute Lung Injury: Investigations Inspired by the SARS Epidemic and the 2009 H1N1 Influenza PandemicArticle Published on 2013-08-012023-06-14 Journal: Seminars in Respiratory and Critical Care Medicine [Category] MERS, 신종인플루엔자, [키워드] acute respiratory distress syndrome (ARDS) alveolar epithelium Angiotensin-converting enzyme 2 (ACE2) lung endothelium Pulmonary edema [DOI] 10.1055/s-0033-1351122 PMC 바로가기 [Article Type] Article
Time Course and Cellular Localization of SARS-CoV Nucleoprotein and RNA in Lungs from Fatal Cases of SARSResearch Article Published on 2006-02-032022-10-29 Journal: PLoS Medicine [Category] Coronavirus, MERS, [키워드] 2003 acute respiratory syndrome alveolar alveolar epithelium antiviral therapy appear assay association Autopsy Canada case cellular China Clinical course clinical disease collected compared coronavirus detected died disease etiological Evidence finding Hong Kong humans illness onset immunohistochemistry In situ Infected involved knowledge less Localization lung lung tissue Lungs Macrophage macrophages monoclonal antibody nucleoprotein outbreak Pathogenesis Patient patients with SARS pneumocyte Pulmonary pathology Region Replication RNA SARS Coronavirus SARS-CoV Seven symptom onset target the disease time Toronto Treatment viral infection virus widespread [DOI] 10.1371/journal.pmed.0030027 PMC 바로가기 [Article Type] Research Article