SARS-CoV-2 in silico binding affinity to human leukocyte antigen (HLA) Class II molecules predicts vaccine effectiveness across variants of concern (VOC)인간 백혈구 항원(HLA) 클래스 II 분자에 대한 SARS-CoV-2 in silico 결합 친화도는 관심 변이체(VOC) 전반에 걸쳐 백신 효과를 예측합니다Article Published on 2022-05-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha antibody production Antigen arising Beta binding affinity caused class clinical effectiveness concern Delta Effectiveness Gamma HLA Human human leukocyte antigen in silico Lancet leukocyte offer omicron overlap pool predict predicted Predictive SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants spike glycoprotein statistically significant Vaccine variant variants of concern VoC widespread Williams [DOI] 10.1038/s41598-022-11956-5 PMC 바로가기 [Article Type] Article
Study of humoral and cellular immunity in vaccinated with mRNA-1273mRNA-1273 백신을 접종한 체액성 및 세포성 면역 연구Article Published on 2022-05-012022-09-12 Journal: Apmis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition anti-S IgG antibody antibody production cellular immunity cellular response circulating decrease health worker humoral Humoral immunity Humoral response Immunity induce infection with COVID-19 Moderna Moderna vaccine mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273 vaccine Observing Patient Protective antibody raised SARS-CoV-2 second dose subsequent Vaccine Vaccines [DOI] 10.1111/apm.13215 PMC 바로가기 [Article Type] Article
Low clinical protective response to SARS-CoV-2 mRNA COVID-19 vaccine in patients with multiple myeloma다발성 골수종 환자에서 SARS-CoV-2 mRNA COVID-19 백신에 대한 낮은 임상 보호 반응Observational Study Published on 2022-05-012022-09-12 Journal: International journal of hematology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] administration age Analysis anti-CD38 Anti-CD38 antibody antibody antibody production Antibody Response Antibody titer Antibody titers B-cell booster CD19+ Cell clinically conducted coronavirus disease COVID-19 COVID-19 vaccine evaluate evaluated healthy controls IgG immunomodulatory drug Japan lymphocyte lymphopenia mRNA mRNA vaccine much lower Multiple Multiple myeloma Patient patients plasma Plasma cell Plasma cell dyscrasia polyclonal Prevalence Protective protocol receiving SARS-CoV-2 Seropositivity significantly higher significantly lower suggested symptomatic therapy vaccination Vaccine vaccine administration [DOI] 10.1007/s12185-022-03300-4 PMC 바로가기 [Article Type] Observational Study
High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease SeverityCOVID-19 환자에서 낮은 친화도 항체의 높은 역가는 질병 중증도와 관련이 있습니다Article Published on 2022-04-132022-09-12 Journal: Frontiers in Immunology [Category] Coronavirus, COVID19(2023년), SARS, 진단, [키워드] addition Affect affinity analyzed antibodies antibody production Antibody Response Antibody titer Antigen association binding clinical information coronavirus disease COVID COVID-19 COVID-19 patient Critically ill critically ill patients disease Disease progression disease severity domain epitope mapping humoral IgA IgA antibody IgG IgG antibody titer IgM immunoassay Infectious diseases Interaction investigated isotype material maturation pandemic Patient peptide positive Prognostic marker Protein Proteins RBD SARS-CoV2 sera severity specific antibody SPRi (surface plasmon resonance imagery) the RBD titer viral infection [DOI] 10.3389/fimmu.2022.867716 PMC 바로가기 [Article Type] Article
Persistence of Naturally Acquired and Functional SARS-CoV-2 Antibodies in Blood Donors One Year after Infection감염 1년 후 헌혈자의 자연적으로 획득되고 기능적인 SARS-CoV-2 항체의 지속성Article Published on 2022-03-182022-09-11 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] AB0 blood groups Acquired Affect age anti-N antibodies anti-N antibody anti-S antibody antibodies antibody antibody levels antibody production Awareness Blood blood donation blood donor Blood donors Blood Group Cohort Course COVID-19 COVID-19-related symptom declining developmental disease course Europe evaluated FIVE functional groups healthy immune response in vitro individual Infection investigated long-COVID Naturally nine participant produced SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection Seroprevalence Sex significantly lower spike-protein the disease the viral nucleocapsid vaccination Vaccination Status Viral Year [DOI] 10.3390/v14030637 PMC 바로가기 [Article Type] Article
Short-term effectiveness of COVID-19 vaccines in immunocompromised patients: A systematic literature review and meta-analysisReview article Published on 2022-03-012022-10-05 Journal: The Journal of Infection [Category] SARS, 변종, 진단, [키워드] 95% CI anti-SARS-CoV-2 antibody production calculated control group controls COVID-19 COVID-19 infection COVID-19 mRNA vaccine COVID-19 vaccine Diagnosis diagnostic effective Effectiveness groups healthy IgG IgG antibody Immunocompromised Immunocompromised patient Immunocompromised patients Inflammatory investigated laboratory-confirmed literature review malignant disease Medical conditions Meta-analysis much higher objective Odds ratio Prevent Research Result rheumatic disease solid organ transplant Spike protein stratified symptomatic [DOI] 10.1016/j.jinf.2021.12.035 [Article Type] Review article
Recall response to COVID-19 antigen is preserved in people with multiple sclerosis on anti-CD20 medications – A pilot study항-CD20 약물에 대한 다발성 경화증 환자에서 COVID-19 항원에 대한 회상 반응이 보존됨 - 파일럿 연구Article Published on 2022-03-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] Coronavirus, MERS, SARS, 진단, [키워드] anti-CD20 anti-CD20 therapy antibody antibody levels antibody production Antibody Response Antibody titers Antigen B cell B cell depletion booster booster dose booster vaccination Booster vaccine both group Cell Cohort cohorts condition COVID-19 elicited enrolled evaluated humoral immunization implication individual management mean difference medication medications multiple sclerosis no correlation Patient peripheral circulation pilot study preserved proportion recall respond SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 vaccination significantly higher Therapies vaccination [DOI] 10.1016/j.msard.2022.103560 PMC 바로가기 [Article Type] Article
Evaluation of the Levels of Peripheral CD3 + , CD4 + , and CD8 + T Cells and IgG and IgM Antibodies in COVID-19 Patients at Different Stages of Infection감염 단계에서 COVID-19 환자에서 말초 CD3 +, CD4 + 및 CD8 + T 세포 및 IgG 및 IgM 항체의 수준의 평가Research Article Published on 2022-02-232022-08-31 Journal: Microbiology Spectrum [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect antibody production association Blood CD3 CD4 CD45 CD8 Cell Cell-mediated immunity Cellular immune response cellular immune responses cellular immunity changes in China clinical sample clinical samples collected conducted coronavirus COVID-19 cytometry analysis determine died ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Flow flow cytometry Flow cytometry analysis groups healthy individual help Hospitalized IgG IgG and IgM IgM IgM and IgG immune responses immune system Immunity infected with SARS-CoV-2 Infection Level levels of antibodies levels of antibody lymphopenia main role medication moderate Patient patients patients with moderate peripheral Peripheral blood peripheral blood samples recovered patients reduction in reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 treatment SARS-CoV-2-infected patient SARS-CoV-2-infected patients serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 shown significant increase significantly Stage stimulatory Support T cell T cells Vaccine virus was performed were used [DOI] 10.1128/spectrum.00845-21 PMC 바로가기 [Article Type] Research Article
Population antibody responses following COVID-19 vaccination in 212,102 individualsArticle Published on 2022-02-162022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법, [키워드] Affect age antibody antibody production Antibody Response Antibody test benefit ChAdOx1 co-morbidities Community Comorbidities COVID-19 vaccination cross-sectional declines decrease dose England Epidemiology Factor female first dose group help Host identify immune response individual individuals Infection lateral flow Lateral flow test obese of BNT162b2 pandemic Population positive REACT-2 REACT-2 study recipients reduced SARS-CoV-2 second dose Sex significantly smoker Surveillance the SARS-CoV-2 vaccinated individual vaccination Vaccine vaccine doses Vaccines viral infection [DOI] 10.1038/s41467-022-28527-x PMC 바로가기 [Article Type] Article
Pregnant Women Develop a Specific Immunological Long-Lived Memory Against SARS-COV-2임산부는 SARS-COV-2에 대한 특정 면역학적 장수 기억력을 발달시킵니다.Immunology Published on 2022-02-102022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addressed Against analyzed antibody antibody production asymptomatic subjects changes in co-stimulatory molecule comparable decrease elicited expression female Follow-up General population IgG IgG response immune response immune system Immunity immunological Immunological memory Immunological response immunological tolerance increased risk induce Infection Inflammation investigated long term lymphocyte management memory Obstetric organism patients physiological adaptation Pregnancy pregnant pregnant women pro-inflammatory progression Regulatory Result resulting SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection severe disease Specific subset T cell memory T-cell triggered vaccinal while [DOI] 10.3389/fimmu.2022.827889 PMC 바로가기 [Article Type] Immunology