Reconcile the debate over protective effects of BCG vaccine against COVID-19Article Published on 2021-04-162022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] age Atla Bacillus BCG BCG vaccination center COVID-19 COVID-19 outbreak COVID-19 vaccines early stage Effectiveness Epidemiology Evidence Health policy highlight immunization Johns Hopkins University new virus notable observé offer older population pandemic Policy Practice proportion protective effect receive researcher SARS-COV-2 infection stages vaccination Vaccine variety viral infection virus while [DOI] 10.1038/s41598-021-87731-9 PMC 바로가기 [Article Type] Article
Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection폐 선암 환자는 SARS-CoV-2 감염 위험이 더 높습니다Research Paper Published on 2021-01-312022-09-10 Journal: Aging (Albany NY) [Category] 유전자 메커니즘, [키워드] ACE2 addition Alter Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assumed Atla AZU1 Bioinformatics analysis center coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCL9 enzyme expressed FCN3 followed by functional Gene Expression Omnibus higher risk HYAL1 IL6 immunological IRAK3 lung adenocarcinoma mechanism microRNA MicroRNAs miR-125b-5p miRNA MMP12 mRNA mRNAs network Patient patients profile pulmonary inflammation receptor risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility screened signaling pathway tissue Toll-like receptor was increased [DOI] 10.18632/aging.202375 PMC 바로가기 [Article Type] Research Paper
Decreased expression of JAK1 associated with immune infiltration and poor prognosis in lung adenocarcinomaResearch Paper Published on 2021-01-312022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] addition Analysis analyzed Atla Cell cell line CIBERSORT clinical feature clinicopathological parameter correlated correlation database decrease Decreased evaluate examined expression GSEA Immune cell immune cells immune infiltration Jak JAK1 Janus kinase 1 Kaplan–Meier lung adenocarcinoma M1 macrophages macrophages marker Methylation mRNA expression Patient poor prognosis Prognosis prognostic biomarker Prognostic value proportion signaling pathway significantly suggested tumorigenesis was increased was used were used [DOI] 10.18632/aging.202205 PMC 바로가기 [Article Type] Research Paper
Can natural products stop the SARS-CoV-2 virus? A docking and molecular dynamics study of a natural product databaseResearch Article Published on 2021-01-082022-10-31 Journal: Future Medicinal Chemistry [Category] COVID-19, MERS, [키워드] 3CLpro Abstract Atla benefit binding Can catalytic conformation COVID-19 database docking domain drugs enzyme futalosine inhibitor inhibitors Ligand maturation molecular molecular dynamics Molecular dynamics simulation natural natural product atlas product protease residue SARS-CoV-2 suggested target the SARS-CoV-2 Virtual screening was performed [DOI] 10.4155/fmc-2020-0248 PMC 바로가기 [Article Type] Research Article
Rapid single cell evaluation of human disease and disorder targets using REVEAL: SingleCell™Database Published on 2021-01-062022-10-28 Journal: BMC Genomics [Category] COVID-19, [키워드] ACE2 Array native database Atla caused Cell cell type annotation cells cellular co-expression complex coronavirus COVID-19 COVID-19 pandemic Data storage and retrieval database dataset datasets described develop diagnostics disorder evaluate evaluated Evaluating exacerbated example explain expressed expressing expression expression profile facilitate Gene Expression Genes Hierarchical Human human cell human disease hypothese hypotheses include individual cell infected patient Infection infections Infectious disease Information extraction involved less manuscript Metadata Multiple studies oncology Ontology organs platform populations Precision prevalent Protein question Rapid resource returned SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 research SARS-CoV-2 virus SciDB selected Sequencing Single Cell Single cell analysis single-cell single-cell dataset spread of COVID-19 supplementary material target target gene targets threshold tissue TMPRSS2 utility Vaccine viral entry virulence virus worldwide pandemic [DOI] 10.1186/s12864-020-07300-8 PMC 바로가기 [Article Type] Database
Atlas of ACE2 gene expression reveals novel insights into transmission of SARS-CoV-2Research Article Published on 2020-12-262022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] 2019-nCoV ACE2 ACE2 expression ACE2 gene analyzed Atla carrier caused clinical symptom conserved COVID-19 COVID-19 patients DNA expresse expression expression pattern Host hosts human tissue infect mammal mammalian mammalian cell mammals MOST novel Novel coronavirus observé pandemic peptide Potential Potential host reveal SARS-CoV-2 susceptibility tissue transmembrane protein transmission of SARS-CoV-2 viral infection yielding [DOI] 10.1016/j.heliyon.2020.e05850 PMC 바로가기 [Article Type] Research Article
Renal Carcinoma Is Associated With Increased Risk of Coronavirus InfectionsMolecular Biosciences Published on 2020-11-202022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 affected age ANPEP approach Atla bioinformatics Brain Cancer Cancer patients cancer tissue carcinoma Cell cellular immunity chemokine Comorbidity coronavirus Coronavirus infection correlation CoV receptor COVID-19 pandemic cytokine database Diabetes Mellitus DPP4 Endocrine ENPEP estimation exhibited expression expression level GI Tract help Human hypertension immune Immune cell infiltration immune infiltration immunohistochemistry Immunosuppression IMPROVE Increased indicate investigated kidney knowledge liver lung malignancy marker modulating molecular multiple organ pancreas pathogenic mechanism Patient patients profiling analysis protein expression receptor receptor protein receptors renal reproductive organs subtype T cell the disease therapeutic approaches tissue tissues TMPRSS2 Tumor tumor stage were used [DOI] 10.3389/fmolb.2020.579422 PMC 바로가기 [Article Type] Molecular Biosciences
Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analyses컴퓨터 분석을 사용한 SARS-CoV-2 감염 관련 폐암의 잠재적 바이오마커로서의 ACE2 단백질 식별Article Published on 2020-11-012022-09-11 Journal: Genomics [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 expression ACE2 receptor age Analysis analyzed angiotensin-converting enzyme 2 Atla best Biomarker Biomarkers cancer patient caused Clinical characteristics co-expressed COVID-19 COVID-19 disease eight expression Factor functional Functional assessment Gender Genes Host identification interactions investigated knowledge lack lung lung adenocarcinoma lung cancer lung cancer patient lung cancer patients mechanism miRNAs mRNA expression mRNA expression analysis. pandemic performed positive Potential Potential biomarker Prognosis Protein relationship Relationship of lung cancer and COVID-19 SARS-CoV-2 SARS-COV-2 infection signaling pathway Spread survival rate susceptible TFS therapy transcription factors up-regulation was performed [DOI] 10.1016/j.ygeno.2020.09.002 PMC 바로가기 [Article Type] Article
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019Genetics Published on 2020-09-302022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] addition Analysis analyzed association Atla changes in conducted coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-2019 database dataset elevated enrichment analysis examined expression expression level Gene expression profiling GEO GSEA HPA Human immune Immune cell immune cell type immune infiltration in vitro in vivo Infection malignancy marker Methylation Occurrence Ontology Pathway analysis positively correlated PPI Prognosis prognostic biomarker promoter Prostate prostatic adenocarcinoma protein-protein interaction resource serine proteases shown significantly increased survival susceptible the microarray tissue TMPRSS2 TMPRSS2 expression transmembrane serine protease Type type 2 transmembrane serine protease [DOI] 10.3389/fgene.2020.575770 PMC 바로가기 [Article Type] Genetics
Thoughts on detecting tissue distribution of potential COVID-19 receptorsShort Communication Published on 2020-08-122022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] ACE2 Atla BSG caused CD209 CLEC4M Clinical data coronavirus disease COVID-19 COVID-19 infection datasets distribution Epidemic expressed help high-risk organ Human intestine kidney liver Lungs material nerve tissue Novel coronavirus organ organs Placenta receptor Research RNA-Seq searched susceptible tissue Tissue distribution variety Viral pneumonia [DOI] 10.2217/fvl-2020-0136 PMC 바로가기 [Article Type] Short Communication