SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases당화 혈청 알부민의 SARS-CoV-2 스파이크 단백질 결합-COVID-19 임상 증후군의 발병에 대한 잠재적 역할 및 당뇨병 전단계/2형 당뇨병 및 대사 질환이 있는 개인에 대한 편견Article Published on 2022-04-082022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] acute respiratory distress albumin analysed Anti-nucleocapsid antibodies Anti-spike anti-spike and anti-nucleocapsid antibodies antibody atherosclerotic Bacteria Bia binding capture clinical Complete convalescent convalescent plasma COVID-19 Diabetic disease end product explain flight form fusion glycated albumin high affinity Human serum albumin immune evasion immune response immunoglobulins individual mass spectrometry metabolic metabolic disease molecular feature molecular features nucleocapsid nucleocapsid protein Nucleocapsid proteins pathogenic pathology Patient plasma protein plasma proteins Potential pre-fusion preference respiratory distress role SARS-CoV-2 SARS-COV-2 infection semi-automated magnetic rack serum albumin Serum protein serum proteins severity spike Spike protein the spike protein virus viruses [DOI] 10.3390/ijms23084126 PMC 바로가기 [Article Type] Article
Development of magnetic particle-based chemiluminescence immunoassay for measurement of SARS-CoV-2 nucleocapsid proteinSARS-CoV-2 뉴클레오캡시드 단백질 측정을 위한 자성입자 기반 화학발광 면역분석법 개발Article Published on 2022-04-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, 치료제, [키워드] addition antibody antigen detection BALB/c mice capture caused Cell cell line cells chemiluminescence Chemiluminescence enzyme immunoassay chemiluminescence immunoassay Clinical diagnosis coding sequence Coefficient of variance coronavirus disease Coronavirus disease 2019 COVID-19 detection antibody develop development diagnostic disease E. coli cell E. coli cells ELISA enzyme enzyme immunoassay enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated expressed expression fused global pandemic highest immunized immunoassay IPTG kDa mAb mAbs molecular weight monoclonal antibodies monoclonal antibody nucleic acid Nucleic acid detection nucleocapsid protein pandemic disease Precision Protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid secreted selected sensitivity spleen Spread structural protein variance was obtained [DOI] 10.1016/j.jviromet.2022.114486 PMC 바로가기 [Article Type] Article
Plasmonic Detection of SARS-CoV-2 Spike Protein with Polymer-Stabilized Glycosylated Gold Nanorods폴리머 안정화 글리코실화 금 나노로드를 사용한 SARS-CoV-2 스파이크 단백질의 플라즈몬 검출Article Published on 2022-03-152022-09-11 Journal: ACS macro letters [Category] COVID19(2023년), SARS, 치료기술, [키워드] binding capture clinical samples Control experiment correlated correlation COVID-19 COVID-19 pandemic demonstrated detection diagnostic dose-dependent galactosamine glycan glycans glycosylated gold highlight immobilization Infection Particle Patient Polymer reducing response responses against rod SARS-CoV-2 SARS-CoV-2 spike protein selective shown spike Spike protein Surveillance swab samples the SARS-CoV-2 utility [DOI] 10.1021/acsmacrolett.1c00716 PMC 바로가기 [Article Type] Article
Real-time infection prediction with wearable physiological monitoring and AI to aid military workforce readiness during COVID-19COVID-19 동안 군사 인력 준비를 돕기위한 웨어러블 생리적 모니터링 및 AI를 통한 실시간 감염 예측Article Published on 2022-03-082022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, [키워드] Algorithm AUC average barrier capture COVID-19 COVID-19 pandemic Defense Department diagnostic diagnostic testing early infection feasibility Garmin healthy Impact impacts implementation increased risk Infection infection risk Infectious diseases Isolation machine learning maintenance observé physiological physiological change positive Predictive Predictive model predictive models reduce risk SARS-CoV-2 service Threats Transmission United State United States [DOI] 10.1038/s41598-022-07764-6 PMC 바로가기 [Article Type] Article
Dietary supplements to reduce symptom severity and duration in people with SARS-CoV-2: study protocol for a randomised, double-blind, placebo controlled clinical trialSARS-CoV-2 환자의 증상 중증도 및 기간을 줄이기 위한 식이 보조제: 무작위, 이중 맹검, 위약 대조 임상 시험을 위한 연구 프로토콜Article Published on 2022-03-032022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] Analysis approach approval approved assessment Canada capture case report form caused clinical trials college Community complementary complementary medicine Controlled clinical trial Controlled trial COVID-19 COVID-19 test death diagnosed with COVID-19 dietary double-blind effective Efficacy Ethical approval Ethics feasibility Frequency Health Health Canada Health status herd immunity hospitalisation hospitalisations Immunity include independent mean score mean scores Medicine monitoring board morbidity Mortality natural network Open Access Outpatient outpatients parallel-group Patient peer-reviewed Placebo placebo-controlled platform Primary outcome product randomised randomised controlled trial recorded recruited reduce registration number Regulatory Research Research Ethics Result Science secondary outcome Secondary outcomes Study protocol symptom severity t tests Treatment Two-arm underlying condition underlying conditions vaccination Vaccine vaccine efficacy Vaccine hesitancy Visual Vitamin C Vitamin D vitamin K Zinc [DOI] 10.1136/bmjopen-2021-057024 PMC 바로가기 [Article Type] Article
Technical procedures and REDCap tools for internet-based clinical trials인터넷 기반 임상 시험을 위한 기술 절차 및 REDCap 도구Article Published on 2022-03-012022-09-11 Journal: Contemporary clinical trials [Category] 임상, [키워드] Automation capture clinical clinical trial clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 Data base management feature flexible Hydroxychloroquine Patient-oriented research Pragmatic Prophylaxis REDCap researcher Support survey Technical procedure Treatment Trial trials [DOI] 10.1016/j.cct.2021.106660 PMC 바로가기 [Article Type] Article
Rolling Reviews During COVID-19: The European Union Experience in a Global ContextCovid-19의 롤링 리뷰 : 글로벌 맥락에서 유럽 연합 경험Article Published on 2022-03-012022-08-31 Journal: Clinical therapeutics [Category] MERS, 신약개발, [키워드] accelerate added addressed applied approach approval approved as required benefit capture collected complement conducted Context COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines critical condition disease dynamic regulatory assessment effective Efficiency EMA European European Medicines Agency example expedited approval pathways experience faster focus globe Health authority health emergency help indicate information Intensive learning life-threatening literature medical need not limited offered Other pandemic Patient Regulatory required resource review Rolling rolling review Society submitted the vaccine the vaccines Treatment union unmet need Unmet Needs Vaccine Vaccines website [DOI] 10.1016/j.clinthera.2022.01.001 PMC 바로가기 [Article Type] Article
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbationsCOVID-19 관련 대사 흔적은 다기관 시스템 섭동에 대한 통찰력을 제공합니다Article Published on 2022-03-012022-09-11 Journal: European Journal of Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Affect aligned alteration capture cellular circulating metabolome Comorbidities Comorbidity confounding factor Corona Coronavirus-2 COVID-19 COVID-19 severity damage defined disease driven by hospitalized COVID-19 patient immune activation immunological immunology indicated Inflammation integration metabolite metabolome metabolomics molecular multi Multi-omics Multiorgan multiple pathway multiple pathways network Neuroinflammation neurological organ damage organ systems performed Perturbation perturbations proteomic question recent resource respiratory SARS-CoV-2 Seroconversion severe acute respiratory syndrome Coronavirus severe COVID-19 patients severity switch trajectory unique [DOI] 10.1002/eji.202149626 PMC 바로가기 [Article Type] Article
Development of rapid antigen test prototype for detection of SARS-CoV-2 in saliva samples타액 샘플에서 SARS-CoV-2 검출을 위한 신속 항원 검사 프로토타입 개발Original Article Published on 2022-02-252022-09-10 Journal: Upsala Journal of Medical Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD anti-receptor-binding domain Anti-spike antibody Antigen antigen test Asymptomatic capture Chain Reaction clinical analysis Cohort Combination combinations coronavirus coronavirus disease COVID-19 demonstrated detect detection antibody development diagnostic Diagnostic accuracy Diagnostic method diagnostic methods domain early stage ELISA ENhance enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated exhibited followed by hospitalized COVID-19 patient hospitalized COVID-19 patients immunized improvement individual Infection interquartile range lateral flow lateral flow assay median time NPV onset of symptom pilot study point-of-care testing polyclonal antibodies polyclonal antibody polymerase chain reaction positive PPV RBD reference method respiratory Result reverse transcription Reverse transcription-polymerase chain reaction rRBD rRT-PCR Saliva saliva samples sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus sensitivity severe acute respiratory syndrome Coronavirus specificity Spike protein stratified symptomatic patient tested the median the SARS-CoV-2 validation study virus was used were used [DOI] 10.48101/ujms.v127.8207 PMC 바로가기 [Article Type] Original Article
Electrochemical detection of ACE2 as a biomarker for diagnosis of COVID-19 and potential male infertilityCOVID-19 및 잠재적 남성 불임 진단을 위한 바이오마커로서의 ACE2의 전기화학적 검출Article Published on 2022-02-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, 치료제, [키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Biomarker Blood can not capture Clinical practice complex Covalent biosensing COVID-19 diagnosis of COVID-19 electrochemical potential enzyme Host index infertility male male infertility outcomes peptide Protein Proteins reagents restrict risk SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection secreted serum Serum level serum proteins serum sample serum samples target treating COVID-19 Viral Viral host target. viral invasion Viral load [DOI] 10.1016/j.bios.2021.113788 PMC 바로가기 [Article Type] Article