cellular receptor – Page 3 – Communicable Diseases Research

Aging-Related Impairments to M Cells in Peyer’s Patches Coincide With Disturbances to Paneth Cells

Immunology

Published on 2021-12-062022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

Detailed Analyses of the Expression Patterns of Potential Severe Acute Respiratory Syndrome Coronavirus 2 Receptors in the Human Heart Using Single-Nucleus RNA Sequencing

Cardiovascular Medicine

Published on 2021-11-302022-10-31
Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19,

[키워드] ACE2 ACE2 expression ACE2-positive cell acute respiratory syndrome adipocyte adipocytes analyzed ANPEP BSG cardiac injury cardiovascular complication Cell cell entry receptor cell types cells cellular receptor cellular receptors Characteristics clinical study coronavirus coronavirus 2 coronavirus disease COVID-19 determinant distribution expression expression features expression level fibroblast Frequency heart HSPA5 Human indicated Infection Injury Intervention investigated involved KREMEN1 mechanism NRP1 patients with COVID-19 pattern pericyte pericytes Potential receptor respiratory RNA RNA-Seq SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor sequence similarity significantly significantly higher single-cell level subset susceptibility susceptible target transcriptional ventricular virus receptor
[DOI] 10.3389/fcvm.2021.757362 PMC 바로가기 [Article Type] Cardiovascular Medicine

Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections

비교 게놈 분석은 코로나 바이러스 감염에 대한 다양한 수준의 포유류 적응을 보여줍니다.

Comparative Study

Published on 2021-11-182022-09-10
Journal: PLoS Computational Biology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] 229E ACE2 ACE2 protein ACE2 proteins acting adaptation adaptive Affect Amino acid amino acid substitution amino acid substitutions aminopeptidase aminopeptidase N Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Animal host APN bats binding causative agent cause caused cellular receptor Chinese Chinese Horseshoe bats clade class common cold Comparative coronavirus Coronavirus infection Coronaviruses COVID-19 Evidence evidence of Evolution genomic Genomic analysis HCoV HCoV-229E Health horseshoe horseshoe bats Host host receptor host susceptibility hosts human coronavirus human coronavirus 229E Interaction Lineage lineages mammal mammalian pathogen Pathogens pattern Phylogeny primates Protein receptor Research reservoir resistance to infection resistance to infections respiratory Respiratory Coronavirus reveal rodent rodents SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SARS-like coronaviruses SARS-like virus SARS-like viruses severe acute respiratory coronavirus severe acute respiratory coronavirus 2 severity of symptom shown species Spike protein susceptible symptomatic disease the SARS-CoV-2 these viruses Tolerance Variation Viral viral entry viral infection viral infections Viral vector virus viruses zoonotic origin
[DOI] 10.1371/journal.pcbi.1009560 PMC 바로가기 [Article Type] Comparative Study

The Renin-Angiotensin System: A Key Role in SARS-CoV-2-Induced COVID-19

레닌-안지오텐신 시스템: SARS-CoV-2-유도 COVID-19의 핵심 역할

Review

Published on 2021-11-172022-09-10
Journal: Molecules [Category] MERS, SARS, 유전자 메커니즘,

[키워드] ACE-2 ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected age Ang II Ang II/AT1R axis angiotensin Angiotensin II Angiotensin-converting enzyme ARDS Asia AT1R balance blood pressure cardiovascular diseases cascade causative agent cellular receptor characterized Comorbidities Comorbidity complications coronavirus coronavirus disease Coronavirus disease 2019 correlation country COVID-19 Cytokine storm diabetes downregulation dual dysregulation effective electrolyte balance Europe Factor feature followed by Gender Genetic polymorphism genetic polymorphisms Health Organization higher risk Host host susceptibility factors human tissue Hypercoagulation individual Infection Interaction involved less lung Lungs mechanism morbidity Mortality Multiple organ damage organ damage organs other organs outcome overactivation pandemic pathogenicity pathology produced proinflammatory promote RAS RAS imbalance receptor renin–angiotensin system respiratory respiratory distress risk factor role SARS-CoV-2 severity spread to subsequent syndrome the disease type I underlying diseases Vaccine vasoconstriction Viral virus while WHO World Health Organization Wuhan Wuhan, China
[DOI] 10.3390/molecules26226945 PMC 바로가기 [Article Type] Review

Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects

Physiology

Published on 2021-11-152022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

Pathogenesis and Mechanism of Gastrointestinal Infection With COVID-19

Immunology

Published on 2021-11-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] ACE2 acute respiratory syndrome Angiotensin-converting enzyme 2 (ACE2) Anti-inflammatory cause caused Cell cellular receptor coronavirus Coronavirus disease 2019 (COVID-19) COVID-19 cytokine release Cytokine storm decrease downregulation dysfunction enzyme expressing expression functional Gastrointestinal Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract gut–lung axis immune response infect Infectious disease Interaction intestinal intestinal epithelial cell intestinal epithelial cells Local mechanism outbreak pathological mechanism Patient prognosis of patients Pulmonary infection RAS RAS system recent replicated respiratory tract SARS-CoV SARS-CoV-2 SARS-COV-2 infection Spread target tissue viral infection virus cycle
[DOI] 10.3389/fimmu.2021.674074 PMC 바로가기 [Article Type] Immunology

Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein

키메라 스파이크 단백질을 발현하는 VSV 벡터에 의해 유발되는 SARS-CoV-2에 대한 보호 면역 강화

Article

Published on 2021-11-102022-09-12
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 administration Antigen cellular receptor Chimera chimeric coronavirus COVID-19 vaccines cross-neutralizing cross-reactivity dose elicit elicited enhanced expressing Genetic glycoprotein hACE2 Human human ACE2 humoral immune response immunization immunized immunized mice indicate intramuscular intranasal lesion Lungs macaque macaques mice Mouse models NAb nAb response NAbs neutralizing antibody protective immunity RBD receiving Receptor binding domain replacing rVSV-SARS-CoV-2 S protein Safe SARS-CoV SARS-CoV S SARS-CoV-2 SARS-CoV-2 RBD sera serum significantly significantly increased similarity single dose spike Spike protein spikes the S protein the SARS-CoV-2 titers transplantation Vaccines viruses VSV wild-type
[DOI] 10.1038/s41392-021-00797-9 PMC 바로가기 [Article Type] Article

ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics

Research Article

Published on 2021-11-022022-10-28
Journal: Advances in Pharmacological and Pharmaceutical Sciences [Category] COVID-19,

Susceptibility of Dog, Hamster, and Mouse Cells to the Replication-Competent Adenovirus 11p E1/E3 Green Fluorescence Protein Vector Has Implications for the Selection of Animal Vaccine Models

Microbiology

Published on 2021-10-272022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] Ad5 Adenovirus animal animal cells animal model Antigen can be used candidate CD46 Cell cell line cell lines cellular receptor CHO cells Critical cytotoxicity DNA replication dog dose E1/E3 vector Efficacy Express expressed expression Fluorescence generate GFP GFP expression green hamster host cell Human in vitro experiments infect infecting Infection manifested MDCK cells Model mouse not express Protein qPCR assay RCAd11pGFP SARS-CoV-2 vaccine Selection specificity susceptibility the vaccine Trial undetectable Vaccine Vaccines vector viral DNA virus virus infection virus particle
[DOI] 10.3389/fmicb.2021.698999 PMC 바로가기 [Article Type] Microbiology

Changes in the SARS-CoV-2 cellular receptor ACE2 levels in cardiovascular patients: a potential biomarker for the stratification of COVID-19 patients

심혈관 환자에서 SARS-CoV-2 세포 수용체 ACE2 수준의 변화: COVID-19 환자 계층화를 위한 잠재적 바이오마커

Original Article

Published on 2021-10-212022-09-11
Journal: GeroScience [Category] MERS, SARS, 바이오마커,

[키워드] ACE2 ACE2 expression ACEi activities activity affected angiotensin Angiotensin converting enzyme 2 (ACE2) Angiotensin-converting enzyme angiotensin-converting enzyme 2 Biomarker blood pressure cardiovascular disease cardiovascular diseases cardiovascular status cellular entry cellular receptor change circulating Comorbidity Compliance controls COVID-19 COVID-19 patient Effect Ejection fraction elevated ELISA enzyme enzyme activity healthy individuals heart failure Heart transplantation human serum hypertension hypertensive hypertensive patients individual inhibitory left left ventricle left ventricular ejection fraction lung lung cancer lung tissue male Male sex medication medications Mortality negative correlation no correlation obese Older overweight Pathomechanism Pathomechanisms Patient patients RAAS inhibitors RAS renin-angiotensin-aldosterone system (RAAS) SARS-CoV-2 serum severe COVID-19 severity Sex Stratification subject the SARS-CoV-2 Thoracic Thoracic Surgery tissue Treatment Ventricle ventricular ventricular ejection was increased without affecting
[DOI] 10.1007/s11357-021-00467-2 PMC 바로가기 [Article Type] Original Article