CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1
CRISPRi는 COVID-19 GWAS 유전자좌를 LZTFL1 및 RAVER1에 연결합니다.
Article
[키워드] activated
Affect
affected
airway
Analysis
antiviral immune response
antiviral response
cell lines
chromosome
coactivator
coding regions
conducted
COVID-19
COVID-19 disease
COVID-19 disease severity
CRISPRi
Critical
Critical illness
dataset
datasets
disease severity
epithelial cell
epithelial cells
exonic region
expression
finding
funding
Gene expression analysis
Genes
Genetic variant
Genome-wide association studies
Genome-wide association study
GWAS
highest
Host
humans
ICAM1
identified variant
identify
IFIH1
indicated
induce
intron
investigated
loci
locus
lung
lung epithelial
lung epithelial cell
Lung epithelial cells
LZTFL1
MDA5
neighbouring genes
NIH
non-coding regions
pathway
RAVER1
Region
regulated
risk allele
RNA-Seq
significantly
sn/scRNA-seq
SNPs
susceptible
variant
Viral
viral clearance
was performed
weakened
with COVID-19
[DOI] 10.1016/j.ebiom.2021.103806 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.ebiom.2021.103806 PMC 바로가기 [Article Type] Article