Comparative genomic analysis of the human genome and six bat genomes using unsupervised machine learning: Mb-level CpG and TFBS islands비지도 머신 러닝을 사용한 인간 게놈과 6개의 박쥐 게놈 비교 게놈 분석: Mb 수준 CpG 및 TFBS 섬Comparative Study Published on 2022-07-082022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure 3D Structures addition Algorithm Analysis artificial artificial intelligence bat bats binding Centromeric heterochromatin characteristic Characteristics chromosomes class Clustering Comparative conducted contributing to CpG diagnostic dinucleotide disease-causing distribution Ebola Emerging infectious disease feature Features function Gene Expression Genome genomes genomic Genomic analysis help hosts Human Human genome humans Infectious disease information Interaction involved knowledge machine machine learning motif natural reservoir nuclear oligonucleotide Oligonucleotide composition oligonucleotides Protein Region regions Regulation reveal RNA viruses SARS-CoV-2 self-organization Self-organizing map Self-organizing map. sequence TFS the SARS-CoV-2 thought transcription factor transcription factors variety virus viruses zoonotic [DOI] 10.1186/s12864-022-08664-9 PMC 바로가기 [Article Type] Comparative Study
Controlling SARS-CoV-2 in schools using repetitive testing strategies반복적인 테스트 전략을 사용하여 학교에서 SARS-CoV-2 제어Article Published on 2022-07-052022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] absenteeism Administered Analysis approach approved attack rate Child children class contrary controlling COVID-19 Epidemic epidemic control Epidemiology global health Human Infection Infectious disease Intervention Isolation Microbiology mitigate Number of school positive primary school reactive reduce reduced repetitive testing. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant School Schools screened significantly Spread symptomatic symptomatic individual symptomatic individuals the epidemic the SARS-CoV-2 thresholds time intervals triggered vaccination Vaccine while [DOI] 10.7554/eLife.75593 PMC 바로가기 [Article Type] Article
A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape상어 유래 단일 도메인 항체 클래스는 SARS 관련 코로나바이러스와 중화 및 오미크론 탈출의 구조적 기초를 광범위하게 중화할 수 있습니다Article Published on 2022-07-012022-09-11 Journal: Small methods [Category] COVID19(2023년), SARS, 변종, [키워드] administration affinity Alpha antibodies antibody Basis bat Beta beta variants bind binding class complementary conserved coronavirus Delta disrupt domain epitope escape hidden impair Interaction Lambda mice motif Mutation neutralization Neutralizing activity offer omicron Omicron variant pangolin Prophylactic PROTECT RBD Receptor binding domain receptor binding domain (RBD) reported sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus therapeutic option unique variant variants variants of concern variants of concerns (VOCs). VOCs Wuhan β-sheet [DOI] 10.1002/smtd.202200387 PMC 바로가기 [Article Type] Article
Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors than Isoflavone and Flavones상업적으로 이용 가능한 플라보놀은 이소플라본 및 플라본보다 더 나은 SARS-CoV-2 억제제입니다Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] 50% effective concentration acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-SARS-CoV-2 apigenin Atazanavir Better Calu Calu-3 calu-3 cells circulating class comparable Compound coronavirus COVID-19 COVID-19 treatment different disease different diseases drugs evaluate ExoN exonuclease Fisetin flavone flavones flavonoids flavonol flavonols fruits Genistein humoral immune response hydroxyl hydroxyl group hydroxyl groups IMPROVE in silico inhibit SARS-CoV-2 inhibiting inhibitor isoflavone kaempferol Luteolin M pro Modification molecular molecular docking myricetin natural product Orientation potency protease quercetin SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus target TNF-α Treatment Vaccines variants variants of concern [DOI] 10.3390/v14071458 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopesSARS-CoV-2 Delta 변이체는 주로 클래스 1 및 2 항체 에피토프에 초점을 맞춘 항체 반응을 유도합니다Article Published on 2022-06-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition antibodies antibody Antibody binding antibody epitope antibody immunity Antibody Response Antibody responses antigenic Beta Beta variant binding class D614G Delta delta variant Effect elicit elicited epitope Epitopes exposure help Impact induce Infection infections K417N mRNA mRNA vaccine Mutation neutralization Neutralizing antibody response polyclonal polyclonal antibody RBD Receptor-binding domain reduce responses SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variant SARS-CoV-2 variants specificity the RBD the receptor-binding domain vaccination Vaccinations Vaccine variant virus viruses [DOI] 10.1371/journal.ppat.1010592 PMC 바로가기 [Article Type] Article
Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children소아에서 SARS-CoV-2 감염에 대한 효과적인 고처리량 RT-qPCR 스크리닝Article Published on 2022-06-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Alpha Alpha variant approach children class correlated delta variant Deprivation diagnosed effective Frequency Germany incidence indicated individual Infection infection control Local Non-invasive positive powerful tool RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 surveillance SARS-CoV-2 testing School Schools sensitivities sensitivity statistical Support Surveillance tested variant Viral load viral loads [DOI] 10.1038/s41467-022-30664-2 PMC 바로가기 [Article Type] Article
Immune Response and Safety of SARS-CoV-2 mRNA-1273 Vaccine in Patients With Myasthenia Gravis중증 근무력증 환자에서 SARS-CoV-2 mRNA-1273 백신의 면역 반응 및 안전성Observational Study Published on 2022-06-212022-09-12 Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% CI activity adverse event AEs baseline blood sample cellular Cellular immune response cellular response changes in class classification clinical clinically collected Combined therapy conducted coronavirus disease correlated country Course COVID-19 determine doses Efficacy ELISA Evidence first dose humoral immune response immunosuppressive drug immunosuppressive therapy induce interferon gamma Messenger RNA mRNA mRNA vaccination mRNA-1273 mRNA-1273 vaccine Myasthenia occurred Participants Patient performed plasma Prednisone Primary outcome Prospective Study provide receiving response Safe Safety SARS-CoV-2 second dose Seroconversion significant changes in statistically significant Surveillance Symptom T-cell T-cell Response the disease the patient vaccination vaccination schedule Vaccine were assessed were measured worsening [DOI] 10.1212/NXI.0000000000200002 PMC 바로가기 [Article Type] Observational Study
Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins기억 B 세포의 분석은 변이체 SARS-Cov-2 스파이크 단백질의 N-말단 도메인에서 보존된 중화 에피토프를 식별합니다Article Published on 2022-06-142022-09-11 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] anti-NTD neutralizing antibodies. antibodies antibody capture Cell class clinical outcomes Cohort conserved contribute Course domain epitope Epitopes Gamma group identify infected individuals Infection memory B cell memory B cells N-terminal domain neutralized Neutralizing Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses neutralizing epitope NTD omicron plasma Plasma cell probe producing Rapid RBD Re-infection Receptor-binding domain recruitment SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants Spike protein spike trimer Subsequent infection subsequent infections target targeted epitope vaccination variant [DOI] 10.1016/j.immuni.2022.04.003 PMC 바로가기 [Article Type] Article
Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccineesCOVID-19 mRNA 백신에 있는 Omicron BA.1 및 BA.2 중화 항체의 해부학Article Published on 2022-06-132022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered antibody BNT162b2 BNT162b2 mRNA vaccine class conserved COVID-19 COVID-19 pandemic cross-neutralize cross-neutralizing antibodies cross-neutralizing antibody cross-protection Donor Effect elicited epitope Epitopes Evidence germlines IGHV1-58 IGHV1-69 IGHV2-5 mitigate molecular molecular basis mRNA mRNA vaccine NAb NAbs neutralization neutralize Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody not neutralize NTD omicron other coronaviruses predominant question RBD Receptor binding domain recognize Region S protein SARS-CoV-1 SARS-CoV-1 virus SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccines seronegative seropositive Spike protein tested the S protein the SARS-CoV-2 vaccination Vaccine design vaccinee Vaccines variants variety virus Wuhan [DOI] 10.1038/s41467-022-31115-8 PMC 바로가기 [Article Type] Article
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like ProteaseSARS-CoV-2 파파인 유사 프로테아제 표적화의 진행 상황 및 과제Review Published on 2022-06-092022-09-11 Journal: Journal of medicinal chemistry [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료제, [키워드] addition Antiviral antiviral drug target approval approved causative agent challenge class cleavage clinic combating COVID-19 pandemic Encouraging highlight Host include inhibitor inhibitors innate immune response knowledge mechanism modulate molnupiravir Nirmatrelvir offer pandemic Papain-like protease pharmacokinetic polymerase polyprotein Progress Protease inhibitor Remdesivir Ritonavir SARS-CoV-2 structure-based design targeting the SARS-CoV-2 U.S. FDA Vaccine variant variants viral infection [DOI] 10.1021/acs.jmedchem.2c00303 PMC 바로가기 [Article Type] Review