Treatment of severe acute ulcerative colitis in SARS-CoV-2 infected patients: report of three cases and discussion of treatment optionsCase Series Published on 2021-04-292022-10-28 Journal: Therapeutic Advances in Gastroenterology [Category] COVID-19, [키워드] acute respiratory syndrome acute ulcerative colitis Alpha Asymptomatic biopsies Case series clinical clinical observations coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient diagnosed Diagnosis drug Evidence Future Histopathology IBD immunomodulatory drug immunomodulatory drugs Inflammatory bowel disease inhibitors International knowledge nasopharynx National Necrosis pandemic parameters Patient patients patients with COVID-19 question Research RT-PCR SARS-CoV-2 Standard steroid Steroids stools therapeutic Therapies therapy treated Treatment treatment regimen ulcerative colitis use of steroids [DOI] 10.1177/17562848211012595 PMC 바로가기 [Article Type] Case Series
Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damageCOVID-19 환자의 SARS-CoV-2 RNA의 사후 사후 매핑 및 조직 손상과의 상관 관계Research Article Published on 2021-03-302022-09-10 Journal: eLife [Category] SARS, 진단, 치료기술, 치료제, [키워드] accumulate addition Autopsies Autopsy Blood blood clotting bloodstream cause caused circulating clinical clinical observations coronavirus correlation COVID-19 Deceased detect died disease dissemination distribution drug treatment drug treatments early post-mortem interval effective example experiment extrapulmonary tissue feature help histology host response human body Hypothesis immune reaction impacted Infection Inflammation involved leads lung tissue Lungs more difficult Multiorgan dysfunction New coronavirus observation organ organs other organ other organs pathophysiology Patient patients with COVID-19 performed postmortem examination postmortem examinations postmortem interval Protein provide question regions remained Research SACs sampling SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Support systemic disease tissue tissue damage tissue degradation tissues transmission electron microscopy Travel Viral Viral load viral particle Viral RNA Viremia virus were used while [DOI] 10.7554/eLife.60361 PMC 바로가기 [Article Type] Research Article
COVID-19 engages clinical markers for the management of cancer and cancer-relevant regulators of cell proliferation, death, migration, and immune responseCOVID-19는 암 관리 및 세포 증식, 사멸, 이동 및 면역 반응의 암 관련 조절자를 위한 임상 마커를 사용합니다.Article Published on 2021-03-042022-08-31 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법, [키워드] biological processe biological processes Cancer cancer patient Cancer patients Cancer therapy Cell cell proliferation clinical clinical decision clinical marker clinical markers clinical observations COVID-19 death Diagnosis diagnostic Diversity EGF endothelial engage Engagement epidemiological epithelial FGF immune response immune system immune system cells infected with SARS-CoV-2 initiated Intersection management marker mechanism Migration modifications network network analysis observation pathway Pathways predicted Prognosis provide rationale regulator Regulatory Regulatory networks retrieved SARS-CoV-2 smooth muscle Support Symptom TGFβ Treatment Tumor tumor suppressors tumorigenesis understanding VEGF virus was used [DOI] 10.1038/s41598-021-84780-y PMC 바로가기 [Article Type] Article
S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates코로나19 소단위 백신 후보 S-트리머, 비인간 영장류 보호 면역 유도Article Published on 2021-03-012022-09-12 Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] adjuvant alum animal model animal models Antigen AS03 Cellular immune response clinical observation clinical observations controls COVID-19 COVID-19 pandemic CpG effective enveloped RNA viruses host cells immune responses immunization immunized immunogenicity induce Like Lungs Neutralizing antibodies neutralizing antibody non-human primates pandemic platform protective immunity reduction rhesus macaque rhesus macaques RNA viruses Safe SARS-CoV-2 SARS-CoV-2 spike protein Spike protein subunit Subunit vaccine surface antigen TLR9 trimeric Vaccine vaccine candidate Vaccines Viral load viral loads water [DOI] 10.1038/s41467-021-21634-1 PMC 바로가기 [Article Type] Article
Comprehensive Landscape of Heparin Therapy for COVID-19COVID-19에 대한 헤파린 요법의 종합적인 전망Review Published on 2021-02-152022-09-11 Journal: Carbohydrate polymers [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition administration adverse effect adverse effects Anti-inflammation Anti-inflammatory Anticoagulant anticoagulant agent anticoagulation antiviral activities antivirus binding biochemical caused cells clinical clinical observation clinical observations Comprehensive concerning coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect Effectiveness Evidence heparin in vitro study Infection landscape observation pandemic coronavirus pharmacological mechanism Protein public health emergency pulmonary thrombosis respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein systemic symptom systemic symptoms the Spike therapy thrombosis Viral viral infection [DOI] 10.1016/j.carbpol.2020.117232 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19SARS-CoV-2는 인간의 장에서 SARS-CoV보다 더 강력한 선천 면역 반응을 유도하고 덜 효율적으로 복제합니다.Article Published on 2021-01-012022-09-11 Journal: Cellular and molecular gastroenterology and hepato [Category] SARS, 치료기술, [키워드] Activation alternative route chemokines clinical observation clinical observations coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines dissemination Ex vivo gastrointestinal tract Gene Expression Gut Hong Kong Human human liver immune activation immunohistochemistry indicated infect infected with SARS-CoV-2 Infection Infectious virus Innate innate immune response interferon interferons intestinal epithelium intestinal tissue intestinal tissues intestine kidney tissues less manifestation Particles Patient patients plaque assays pro-inflammatory cytokine pro-inflammatory cytokines processed qRT-PCR replicate replicated Replication replication kinetics reported respiratory response robust SARS-CoV SARS-CoV-2 suggested surgical surgical operation surgical removal tissue tissues type I type I and type III interferons type III Type III interferons virus [DOI] 10.1016/j.jcmgh.2020.09.017 PMC 바로가기 [Article Type] Article
Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection여러 막 결합 세린 프로테이나제에 의한 SARS-CoV-2 S 단백질 프라이밍은 바이러스 감염력 및 전신 COVID-19 감염을 설명할 수 있습니다Review Published on 2020-12-062022-09-12 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 진단, [키워드] α2-AP, α2-antiplasmin ACE2 ACE2, angiotensin-converting enzyme 2 activate addition Affect causative agent cause caused cell tropism circulating clinical observations Concentration contribute coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 infection COVID-19 pandemic death determine effective Exclusive or explain expression Factor HAI-1/SPINT1 heart host cells Infection infection rate information inhibitor inhibitors kidney kidney damage kidneys liver liver dysfunction Lungs MASPs, membrane-associated serine proteinases membrane fusion membrane-associated serine proteinases (MASPs) membrane-bound MERS, Middle East respiratory syndrome much higher myocardial injury Neurological complications organ other organ other organs PAI-1, plasminogen activator inhibitor 1 PCI, protein C inhibitor positive predominant proteinase QM/MD, quantum mechanical/molecular dynamics receptor relative SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS, Severe acute respiratory syndrome Sepsis Serine serine proteinase serpins significantly higher similarity spike (S) protein Spike protein SPINT1 SPINT2 structure–function relationship synergy term the disease the patient the SARS-CoV-2 thrombotic TMPRSS2 transmembrane transmission rate Treatment uPA, urokinase-type plasminogen activator Vaccine viral fusion viral spike protein viral spike proteins [DOI] 10.1074/jbc.REV120.015980 PMC 바로가기 [Article Type] Review
Defining heart disease risk for death in COVID-19 infectionCOVID-19 감염에서 사망에 대한 심장 질환 위험 정의Article Published on 2020-12-012022-09-11 Journal: QJM: An International Journal of Medicine [Category] MERS, SARS, 바이오마커, [키워드] 95% CI acute coagulopathy Acute kidney injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission analyzed arrhythmia cardiovascular cardiovascular disease clinical observation clinical observations clinically evaluated collected Comorbidities Complication coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient COVID-19 patients CVD death death in COVID-19 demographic demographic data disease disease risk glucocorticoid independent risk factor independent risk factors Infection intensive care intensive care unit admission Intervention Laboratory laboratory findings laboratory-confirmed SARS-CoV-2 infection mechanical ventilation men Mortality mortality rate multivariable Cox regression Older Older age outcome outcomes Patient patients with COVID-19 proportion respiratory respiratory distress SARS-COV-2 infection severe acute respiratory syndrome Coronavirus significantly syndrome therapy Treatment ventricular ventricular fibrillation ventricular tachycardia Vigilance Vitamin Vitamin C Wuhan Wuhan, China [DOI] 10.1093/qjmed/hcaa246 PMC 바로가기 [Article Type] Article
Ocular Involvement in Coronavirus Disease 2019: Up-to-Date Information on Its Manifestation, Testing, Transmission, and PreventionMedicine Published on 2020-11-302022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome addition adopted caused clinical observations conjunctivitis Contact coronavirus coronavirus disease COVID-19 described digestive droplet effective incidence Infection information Involvement Laboratory testing manifestation measure mucosal surface ocular Ocular surface pandemic positive SARS-CoV-2 result potential transmission prevention prevention of COVID-19 required risk SARS-CoV-2 SARS-COV-2 infection specimen Testing Transmission virus [DOI] 10.3389/fmed.2020.569126 PMC 바로가기 [Article Type] Medicine
Centrality of G6PD in COVID-19: The Biochemical Rationale and Clinical ImplicationsMedicine Published on 2020-10-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Achille aldosterone (Ald) Analysis antimalarial antioxidant Asymptomatic biochemical biochemical pathway Biomarker clinical Clinical data clinical manifestation clinical observations Cohort Course COVID-19 COVID-19 pathogenesis Critical dataset Defense deficiency develop disease epidemiological Europe explain Fact G6PD Glucose-6-phosphate glucose-6-phosphate dehydrogenase (g6pd) glutathione GSH health condition immune response increase Inflammatory investigated manifestation mechanism metabolic syndrome MONITOR mortality rate nitric oxide nitric oxide - NO observation pathway Patient PMC RAAS rationale reactive oxygen species reactive oxygen specy ROS SARS-CoV-2 syndrome Treatment Trigger unique were used [DOI] 10.3389/fmed.2020.584112 PMC 바로가기 [Article Type] Medicine