Induction of remission with tacrolimus in a patient with severe acute, cortisone refractory ulcerative colitis and severe Covid-19 pneumonia: a case reportCase Report Published on 2022-01-152022-10-27 Journal: BMC Gastroenterology [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] acute respiratory syndrome adjusted Admission Case report clinical response Clinical symptoms clinician coronavirus cortisone cortisone therapy Course COVID-19 COVID-19 pneumonia defined discharged dose High-dose hospital IBD Immunosuppression IMPROVE increased risk induction infected patient Infection Inflammatory Inflammatory bowel disease inhibitor initiated intravenous managing medication outbreak pandemic Patient patients positive Prednisolone presenting regimen risk SARS-CoV-2 severe coronavirus disease Symptoms the patient therapeutic option therapy treat Treatment ulcerative colitis viral infection viral reactivation was tested [DOI] 10.1186/s12876-022-02094-3 PMC 바로가기 [Article Type] Case Report
Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and HypercytokinemiaMedicine Published on 2022-01-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] “cytokine storm” acute respiratory distress syndrome (ARDS) All the patient analyzed benefit Berlin C-reactive protein Case series clinical response clinically coronavirus 2019 disease COVID-19 Critically ill patient cytokine cytokine removal D-dimer death dysregulated Europe evaluate failure ferritin Germany hemoadsorption high risk hypercytokinemia ICU identifying IL-6 Ill improvement in-hospital mortality inflammatory biomarkers Inflammatory response intensive care interleukin-6 Invasive mechanical ventilation organ dysfunction Oxygenation PaO pathophysiology Patient plasma Prone position prone positioning reduction in rescue respiratory Respiratory failure Retrospective study SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia severe respiratory failure significant difference single center SOFA score Therapies therapy Treatment with COVID-19 [DOI] 10.3389/fmed.2021.779038 PMC 바로가기 [Article Type] Medicine
Neutralization Assessments Reveal High Cardiothoracic Ratio and Old Age as Independent Predictors of Low Neutralizing Antibody Titers in Hemodialysis Patients Receiving a Single Dose of COVID-19 VaccineArticle Published on 2022-01-072022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] acute respiratory syndrome age antibody applied assessment ChAdOx1 clinical response Cohort coronavirus COVID-19 COVID-19 vaccine domain Effectiveness elicited enrolled enzyme-linked immunosorbent first dose GMT healthy control healthy subject Hemodialysis humoral International mRNA-1273 Multiple linear regression NAb neutralization titer Neutralizing antibodies neutralizing antibody Patient patients predict predictor quantification Ratio receiving regression analysis SARS-CoV-2 single dose single-center study the SARS-CoV-2 titer viral spike protein [DOI] 10.3390/jpm12010068 PMC 바로가기 [Article Type] Article
The clinical efficacy of low-dose whole-lung irradiation in moderate-to-severe COVID-19 pneumonia: RTMX-20 trialClinical Trial Published on 2022-01-012022-10-04 Journal: Radiotherapy and oncology : journal of the Europea [Category] SARS, 임상, [키워드] acute respiratory distress syndrome (ARDS) Clinical efficacy clinical response cohort study COVID-19 COVID19 pneumonia distress dose IMPROVE Low dose radiotherapy (LDRT) low-dose moderate-to-severe COVID-19 patients patients with COVID-19 patients with moderate Radiotherapy SARS-CoV2 syndrome Trial [DOI] 10.1016/j.radonc.2021.11.013 PMC 바로가기 [Article Type] Clinical Trial
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistaminesObservational Study Published on 2022-01-012022-10-05 Journal: Journal of investigative medicine : the official p [Category] SARS, 임상, [키워드] acute illness addressed alteration anaphylaxis Anecdotal antagonist Asymptomatic CD28 CD4+ CD8+ Cell cells central memory characteristic characterized Clinical improvement clinical response COVID COVID-19 diagnostic diagnostic tests effector memory etiology expression Hospitalization HRA immunologic tests individual Long long-COVID mechanism Mild participant Patient Perturbation programmed cell death Protein quantified question questionnaire receptor reduced regulated reported required routine SARS-CoV-2 SARS-COV-2 infection Symptom symptomatic Symptoms T cell T cell subset T cells [DOI] 10.1136/jim-2021-002051 PMC 바로가기 [Article Type] Observational Study
Strategies to minimize heterogeneity and optimize clinical trials in Acute Respiratory Distress Syndrome (ARDS): Insights from mathematical modelling급성 호흡 곤란 증후군(ARDS)에서 이질성을 최소화하고 임상 시험을 최적화하기 위한 전략: 수학적 모델링의 통찰력Article Published on 2022-01-012022-09-11 Journal: EBioMedicine [Category] 임상, [키워드] Action angiotensin approval baseline biologic Biomarker Biomarkers center Characteristics clinical response clinical responses clinical trial clinically Clustering complex interaction Corticosteroids COVID-19 Critical Critical care Critical illness Curie determined by Diabetic diabetic patients disease severity disparate driven by example expression foundation heterogeneity heterogeneity of treatment effect hyperinflamed hyperinflamed patient hyperinflamed patients identify IL6 immune response immunomodulation immunomodulatory Immunomodulatory therapies Immunosuppression individual Infection initiated Injury insight manuscript marker Mathematical modelling Microthrombosis Model modelling modulating neutrophil neutrophil recruitment NMF non-negative matrix factorization obese Older older patients outcome parameter Patient predict predicted Predictive Principal component principal component analysis RAS reduction Renin renin-angiotensin system representing Research respiratory respond responsible Strategy supported System System biology systemic cytokine Systems biology the disease therapy Treatment treatment initiation trials Trust [DOI] 10.1016/j.ebiom.2021.103809 PMC 바로가기 [Article Type] Article
Persistent SARS-CoV-2 infection in patients with secondary antibody deficiency: successful clearance following combination casirivimab and imdevimab (REGN-COV2) monoclonal antibody therapy2 차 항체 결핍 환자의 지속적인 SARS-COV-2 감염 : Casirivimab 및 Imdevimab (Regn-Cov2) 모노클로 날 항체 요법에 따른 성공적인 통관Case Reports Published on 2021-12-302022-09-01 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] SARS, 변종, 진단, 치료기술, [키워드] accompanied administration antibody Antibody deficiency Antibody Response Antibody responses antiviral therapy B cell B cell depleting therapy benefit Case report case reports Casirivimab Chronic COVID-19 Chronic lymphocytic leukaemia clearance Clinical improvement clinical recovery clinical response clinical study Clinical use Combination convalescent plasma deficiency delivery depleting ecological ecological niche Effectiveness evade Evidence Evolution failure fatigue female follicular Follicular lymphoma Formal highlight hospitalised Ibrutinib Imdevimab immune evasion Immunotherapy increased risk individuals Infection Inflammation lack lymphoma malaise male monoclonal antibody monoclonal antibody combination nasopharyngeal swabs neutralisation omicron outcome Passive immunisation Patient patients persistent persistent infection Primary and secondary immunodeficiency raised REGN-CoV2 Remdesivir Ronapreve (REGN-COV2) SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants secondary antibody secure Sequence analysis spike variant suffered sustained therapeutic therapy treated Treatment variants variants of concern Viral viral clearance viral evolution virological clearance with COVID-19 withdrawn [DOI] 10.1186/s12941-021-00491-2 PMC 바로가기 [Article Type] Case Reports
Eosinophilic Granulomatosis with Polyangiitis Relapse after COVID-19 Vaccination: A Case ReportCase Report Published on 2021-12-232022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] clinical response COVID-19 diagnosed Dyspnea EGPA Eosinophilic first dose granulomatosis limb mepolizumab Mild monoclonal antibody mRNA BNT162b2 vaccine myalgia occurred polyangiitis Relapse report SARS-COV-2 infection tested treated Treatment Vaccine [DOI] 10.3390/vaccines10010013 PMC 바로가기 [Article Type] Case Report
Molecular and Clinical Aspects of COVID-19 Vaccines and Other Therapeutic Interventions Apropos Emerging Variants of ConcernPharmacology Published on 2021-12-232022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome aspect cell-based therapies cellular therapy clinical clinical response clinical responses complement concern coronavirus Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines effective Efficacy effort evade Evidence healthcare immune protection immunological Immunological response Immunomodulatory agent imperative molecular molecular mechanism monoclonal antibodies monoclonal antibody Other Protective recent recent finding SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 variant Therapeutics therapy trajectory Treatment treatment regimen vaccination Vaccine Vaccines variant variant of concern variants of SARS-CoV-2 vicious cycle virulent VOCs while [DOI] 10.3389/fphar.2021.778219 PMC 바로가기 [Article Type] Pharmacology
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular diseaseCardiovascular System & Vascular Biology Published on 2021-12-152022-10-31 Journal: Clinical Science (London, England : 1979) [Category] COVID-19, SARS, [키워드] ACE2 Activation acute respiratory syndrome alterations angiotensin converting enzyme 2 angiotensin-converting enzyme 2 antibody cause caused CD147 Cell cellular clinical response contributing to coronavirus COVID-19 death disease disrupt dysfunction elicited Endothelial cell events exposure to Extracellular Factor functional Hypothesis Implications in vitro induce infect infected patients Infection involved Ligand mechanism Microvascular damage Microvascular disease microvascular injury Migration mRNA neutralisation Patient pericyte Peripheral blood pro-apoptotic pro-inflammatory molecule Protein receptor recombinant S protein reduced rescued S protein SARS-CoV-2 secretion spike Spike protein stimulate Stress Support tested the cytokine storm the S protein the SARS-CoV-2 therapeutic variant Vascular wildtype [DOI] 10.1042/CS20210735 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology