combination therapies – Page 3 – Communicable Diseases Research

Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection

TMPRSS2와 카텝신 B/L을 함께 표적으로 삼는 것은 SARS-CoV-2 감염에 대해 상승적일 수 있습니다

Research Article

Published on 2020-12-082022-08-13
Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, SARS,

[키워드] ‘repurposing’ drugs achievement activate Activation blockade blocking blocking virus entry cathepsin Cathepsin B/L Cell cell lines cell population levels cell types cells clinical trials combination therapies combination therapy corresponding protease expression level COVID-19 COVID-19 pandemic cysteine cysteine protease cysteine proteases deployability dose-dependent manner drug drug combination drug combinations drugs targeting Effect Efficacy Efficiency effort entry of SARS-CoV-2 Evidence expression level facilitate help highlighting host protease host proteases host serine protease IMPROVE in vitro in vitro data in vivo independent independent entry pathway inhibitor inhibitors involved mathematical mathematical model minimal toxicities pathway Pathways potential treatment option predict predicted Prevent protease Proteases required SARS-CoV entry SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine Single Cell Spike protein synergistic Synergistic drug combination Synergistic drug combinations synergy target cell target cells targeting the cell tissue tropism TMPRSS2 toxicities Treatment triggered virus entry
[DOI] 10.1371/journal.pcbi.1008461 PMC 바로가기 [Article Type] Research Article

Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes

SARS-CoV-2 감염 및 인간의 정량적 표현형에 관여하는 ACE2 및 TMPRSS2 유전자의 유전적 변이체 간의 연관성 부족

Genetics

Published on 2020-06-082022-08-13
Journal: Frontiers in Genetics [Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 gene acute respiratory distress acute respiratory distress syndrome angiotensin angiotensin converting enzyme Angiotensin II Anti-inflammatory ARBs ARBs (angiotensin II receptor blockers) association associations Biomarkers blocker carried cause causes Cell chronic inflammation Cohort combination therapies combination therapy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokines death disease enzyme examined example expression female females flu-like symptoms General population genetic data Genetic predisposition Genetic variant Genetic variation genetics Human human genes hypertension include Infection Invasion male medication medications Mild modulate multifactorial no symptoms NSAIDs (non-steroidal anti-inflammatory drugs) nucleotide outcome phenotype PheWAS Pneumonia priming Quantitative reached receptor Receptor Blockers respiratory distress Respiratory distress syndrome responsible S protein sample sizes SARS-CoV-2 SARS-CoV-2 virus Serine serine protease serine protease TMPRSS2 severe cases severe COVID-19 severity of symptoms significantly Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs syndrome threshold thrombocyte Thrombocytes thrombocytopenia TMPRSS2 Usage Variability variant Variation virus clearance Volunteer while
[DOI] 10.3389/fgene.2020.00613 PMC 바로가기 [Article Type] Genetics

Development of multi-specific humanized llama antibodies blocking SARS-CoV-2/ACE2 interaction with high affinity and avidity

Letter

Published on 2020-05-222022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, SARS,

Addressing COVID‐19 Drug Development with Artificial Intelligence

Essay

Published on 2020-04-272022-10-28
Journal: Advanced Intelligent Systems (Weinheim an Der Bergstrasse, Germany) [Category] COVID-19,

[키워드] acute respiratory syndrome antibodies antibody approach approaches artificial artificial intelligence cause clinical trial Combination combination therapies combination therapy composed coronavirus COVID-19 COVID‐19 development drug drug combination Drug development Drug screening Efficacy effort ENhance evaluated Healthcare system identify Inc include Infectious disease intelligence Moderna Multiple outcomes pandemic pathogen Phase I regimen repurposed therapies SARS‐CoV‐2 severe acute respiratory syndrome coronavirus 2 sustained therapy timeline Treatment turn Vaccine Vaccine development Vaccines virus widespread
[DOI] 10.1002/aisy.202000070 PMC 바로가기 [Article Type] Essay

Attenuating the emergence of anti-fungal drug resistance by harnessing synthetic lethal interactions in a model organism

모델 유기체에서 합성 치명적인 상호 작용을 활용하여 항진균제 내성의 출현을 완화

Research Article

Published on 2019-08-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] allele alleles antifungal drug resistance antifungal therapy antimicrobial resistance approach Bacteria best Candida Care caused Cell clinically combination therapies Community community acquired death Deletion drug drug resistance drug-resistant drugs effective Evolution experiments Express expressing FIVE fluconazole fungal Fungal infection fungal infections fungi Gain gain-of-function Genetic genetic component genetic screens genus growth hospitals Host identify Immunosuppressed inactivation incidence Infection infections inhibit inhibited Interaction investigated isolate knowledge life life-threatening mediator mediators Medical care Mortality MRSA mucosal mutant Mutation organism pathogen Pathogens patient population performed phenotype powerful tool Prevent proof proof of concept Protein provide resistance mechanisms responsible Saccharomyces cerevisiae significantly target target proteins Testing therapy thrush Treatment yeast
[DOI] 10.1371/journal.pgen.1008259 PMC 바로가기 [Article Type] Research Article

Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies

병용 요법을 위해 저항성 말라리아 기생충에 대한 클로로퀸의 효과 활용

Research Article

Published on 2019-04-152024-07-27
Journal: BMC Bioinformatics [Category] 말라리아,

[키워드] Chloroquine combination therapies malaria Metabolic modeling
[DOI] 10.1186/s12859-019-2756-y PMC 바로가기 [Article Type] Research Article