Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathyReview Published on 2021-12-192022-10-31 Journal: Experimental Hematology & Oncology [Category] COVID-19, [키워드] activated Activation alveolar capillary leak syndrome Cell cleavage clinical trial coagulation cascade complement Complement activation Complement inhibitor Complement pathway complexes contribute damage-associated molecular pattern DAMP DAMPs Diagnostic Criteria disease endothelial cells endothelial injury Hematopoietic stem cell Hematopoietic stem cell transplantation-associated thrombotic microangiopathy hemorrhage heterogeneity host cells Inflammation Injury lectin pathway life-threatening MASP-2 occur organ damage Pathogenesis Pediatric patient Pneumonia populations procoagulant risk factor role serine protease Stem cell transplantation Symptoms syndrome thrombin thrombotic Treatment Variability [DOI] 10.1186/s40164-021-00249-8 PMC 바로가기 [Article Type] Review
COVID-19 adenovirus vaccine triggers antibodies against PF4 complexes to activate complement and plateletsCOVID-19 아데노바이러스 백신은 PF4 복합체에 대한 항체를 유발하여 보체와 혈소판을 활성화합니다Article Published on 2021-12-012022-09-12 Journal: Thrombosis research [Category] MERS, SARS, 진단, [키워드] activate activating Activation activation of platelet Adenovirus adenovirus vaccine administration aggregation Analysis analyzed Anti-PF4 antibodies antibody caused ChAdOx1 ChAdOx1 vaccine coagulation disorder complement Complement activation complexes Control COVID-19 COVID-19 infection EDTA Effect elevated ELISA enzyme Fcγ-receptor II glycoprotein GPIIb/IIIa receptor healthy donor High-dose human immunoglobulin IgG immunoassay inhibitor Interaction involved Patient PF4 plasma plasma sample Platelet Platelets Platelets aggregation procoagulant Protein receptor reported suppressed the patient therapeutic thrombotic Trigger triggered vaccine-induced thrombotic thrombocytopenia Vaccines were used [DOI] 10.1016/j.thromres.2021.10.027 PMC 바로가기 [Article Type] Article
Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs중증 COVID-19 질환 환자의 폐에서 세포내 보체의 활성화는 폐의 T-세포 활성을 감소시킵니다Immunology Published on 2021-11-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation activity acute respiratory syndrome coronavirus alleviate Asymptomatic bioinformatics cellular and molecular Cellular and molecular mechanisms classical complement Complement activation conducted coronavirus coronavirus 2 COVID-19 COVID-19 patients decrease disease pathology disease severity downregulation Effect examined help Ingenuity Pathway Analysis Intracellular knowledge lung lung cell lung cells Lung pathology Lungs mechanical ventilator mechanism modulation multi-organ failure Novel coronavirus potential mechanisms proinflammatory reduce respiratory respiratory distress responsible RNA sequencing data SARS-CoV-2 SARS-COV-2 infection sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 disease severe COVID-19 patients Severe respiratory distress Support survival T-cell T-cells Treatment upregulation [DOI] 10.3389/fimmu.2021.700705 PMC 바로가기 [Article Type] Immunology
Analysis of transcriptomic data sets supports the role of IL-6 in NETosis and immunothrombosis in severe COVID-19전 사체 데이터 세트의 분석은 중증 covid-19에서 네토 시스 및 면역 혈증에서 IL-6의 역할을 뒷받침합니다.Research Published on 2021-11-142022-09-10 Journal: BMC Genomic Data [Category] MERS, 유전자 메커니즘, [키워드] Activation Blood Blood oxygen saturation cascade co-expression Coagulation coagulation cascade complement Complement activation Complication contributing to correlated COVID-19 COVID-19 disease COVID-19 illness data sets downstream driving dysfunction enrichment analysis event Evidence evidence of expression functional Gene Expression gene set enrichment analysis Genes IL-6 IL-6 expression IL6 immunothrombosis life-threatening lung moderate Mortality negative correlation NETosis Neutrophil extracellular trap Non-survivors oxygen oxygen saturation Pathogenesis pathological process patients with COVID-19 respiratory Respiratory function Result robust Scientific community severe COVID-19 severe COVID-19 disease severe COVID-19 illness severity severity of illness subject supplementary material Support Temporal the disease therapy transcriptional transcriptomic data transcriptomics Treatment Unsupervised clustering up-regulation was performed with COVID-19 [DOI] 10.1186/s12863-021-01001-1 PMC 바로가기 [Article Type] Research
Plasma Gradient of Soluble Urokinase-Type Plasminogen Activator Receptor Is Linked to Pathogenic Plasma Proteome and Immune Transcriptome and Stratifies Outcomes in Severe COVID-19가용성 Urokinase-Type Plasminogen Activator Receptor의 혈장 구배는 병원성 Plasma Proteome 및 면역 전사체와 연결되어 심각한 COVID-19의 결과를 계층화합니다Immunology Published on 2021-10-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, [키워드] 95% confidence interval Activation acute respiratory distress acute respiratory distress syndrome Analysis analyzed ARDS benefit Biomarker caused characteristic circulating Clinical outcome clinical outcomes coagulation disorder coagulation disorders Cohort complement Complement activation coronavirus COVID-19 COVID-19 disease COVID-19 patients Critical care Cutoff cutoff value cytokine Cytokines Cytometry differential expression disease effective expressed faster Flow flow cytometry Gradient hazard ratio hyper-inflammation hypercoagulable Hypercoagulable state hyperinflammation immune mass spectrometry morbidity and mortality Mortality myeloid cell myeloid cells Next-generation sequencing Odds ratio operator pathogenic patient cohort performed Peripheral blood peripheral blood cell peripheral blood cells plasma plasma sample plasma samples plasma suPAR Plaur predict Prognosis proteome proteomics receiver receptor respiratory distress risk stratification SARS-CoV-2 coronavirus Sequencing sequencing data severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients Single-cell RNA sequencing soluble uPAR statistical analyses suPAR survival syndrome systemic hyper-inflammation systemic hyperinflammation Transcriptome urokinase Urokinase-Type Plasminogen Activator was done were measured [DOI] 10.3389/fimmu.2021.738093 PMC 바로가기 [Article Type] Immunology
Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19중요한 COVID-19에서 항체 및 보체 의존성 폐렴 손상과 관련된 향상된 호산구 매개 염증Article Published on 2021-10-052022-09-11 Journal: Cell Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation adaptive immune responses addition airway airways antibody Antibody Response biopsy complement Complement activation complexes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical critical COVID-19 patients Critical disease disease pathogenesis driver enhanced eosinophil evidenced Fcγ receptor FcγR hallmark immune immune complex Immune complexes immune responses Inflammation innate immune responses lung lung biopsies mechanism membrane myeloid cell myeloid cells pandemic Pathogenesis Pneumonia receptor respiratory respiratory specimen respiratory specimens SARS-CoV-2 SARS-COV-2 infection Signaling subsequent T helper vasculature Viral Viral pneumonia [DOI] 10.1016/j.celrep.2021.109798 PMC 바로가기 [Article Type] Article
When Immunity Kills: The Lessons of SARS-CoV-2 OutbreakImmunology Published on 2021-09-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] accumulating acute respiratory distress ARDS Asymptomatic B cell response Complement activation develop disease Evidence Gas exchange immunopathology impair include infected individual Inflammatory knowledge lesson massive alveolar damage Mild SARS-CoV-2 severe disease Spread syndrome systemic manifestation T cell response T cell responses T-cell Response virus clearance while [DOI] 10.3389/fimmu.2021.692598 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 Antibody Isotypes in Systemic Lupus Erythematosus Patients Prior to Vaccination: Associations With Disease Activity, Antinuclear Antibodies, and Immunomodulatory Drugs During the First Year of the Pandemic예방 접종 전 전신 홍반성 루푸스 환자의 SARS-CoV-2 항체 아이소타입: 유행병 첫 해 동안 질병 활성, 항핵항체 및 면역조절 약물과의 연관성Immunology Published on 2021-08-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] a minor Activation activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 albumin all subjects analyzed anti-dsDNA antibodies antibody antibody isotypes Antibody Response antinuclear antibodies antinuclear antibody Arthritis Blood Blood Group BMI Cell cell receptor collected complement Complement activation complement-immunological terms coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19-related symptom dose drug Effects ELISA envelope protein exposure to Fever followed by glucocorticoid Hydroxychloroquine IgA IgG IgM Impact include individual Infection interferon investigated isotype longitudinal samples Lupus lupus (SLE) lupus erythematosus minor multiplex neutralization (effect of) neutralizing capacity objective pandemic Patient patients with SARS-CoV-2 PCR-confirmed progression proportion Proteins respiratory Result Rheumatic diseases rheumatologist risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection serological severe acute respiratory syndrome Coronavirus severe SARS severe SARS-CoV-2 SLE SLE patient smoking steroid Steroids subject Swedish Symptom systemic systemic lupus erythematosus the cell Thromboembolism type I interferon use of hydroxychloroquine vaccination were measured women Year [DOI] 10.3389/fimmu.2021.724047 PMC 바로가기 [Article Type] Immunology
Thromboinflammation Supports Complement Activation in Cancer Patients With COVID-19혈소판 염증은 COVID-19에 걸린 암 환자의 보체 활성화를 지원합니다Immunology Published on 2021-08-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] accompanied Activation addition amyloid A analyzed C1-Inhibitor C3a C5a Cancer cancer patient Cancer patients cascade cascades circulating Coagulation complement Complement activation Complement inhibitor complement inhibitors conducted COVID-19 COVID-19 pathology D-dimer D-dimer level D-dimers described disease pathology dysfunction elevated Endothelial cell Endothelial dysfunction evaluate evaluated examined Factor FEU ICAM-1 increase Inflammation Inflammatory response inhibitors marker objective P-selectin Patient plasma platelet activation receptor Result SC5b-9 serum amyloid significantly increased soluble urokinase plasminogen activator receptor stratified Support systemic inflammation Thromboinflammation thrombomodulin Vascular Vascular damage with COVID-19 [DOI] 10.3389/fimmu.2021.716361 PMC 바로가기 [Article Type] Immunology
Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 PatientsArticle Published on 2021-08-122022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] Activation Alternative pathway alveolar cells Analysis antibody Autopsy C1q capillary caused circulating classical classical pathway complement Complement activation component COVID-19 COVID-19 patient COVID-19 patients Deceased deposition detectable determine died distribution IgG immunofluorescence Increased Inflammation information kidney kidneys liver Local lung Lungs MASP-2 mechanism Mild multi-organ deposition organ pathway Patient patients with COVID-19 performed reported Respiratory failure SARS-CoV-2 specimen Spike protein staining Support the disease tissue tissue damage vessel were stained [DOI] 10.3390/biomedicines9081003 PMC 바로가기 [Article Type] Article