DEGs – Page 3 – Communicable Diseases Research

Differing coronavirus genres alter shared host signaling pathways upon viral infection

Research

Published on 2022-06-132022-10-05
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제,

Organ-specific or personalized treatment for COVID-19: rationale, evidence, and potential candidates

Article

Published on 2022-06-012022-10-04
Journal: Functional & integrative genomics [Category] COVID19(2023년), SARS, 신약개발,

[키워드] A549 acute respiratory syndrome analyzed biological pathway candidate Cell Complication coronavirus coronavirus disease COVID-19 DEGs differentially expressed gene Drug repurposing effective Evidence experiment extrapulmonary organ FDA-approved drug Genes increasingly infected cell involved liver lung alveolar manifestation Multiorgan multisystemic network analysis organ organ-specific Organ-specific treatment Organoid organs Pathogenesis pathophysiology Pathway enrichment analysis Personalized medicine pluripotent stem cell PPI protein-protein interaction reported responsible SARS-CoV-2 SARS-COV-2 infection therapeutic therapeutic strategy therapy Treatment was done were used
[DOI] 10.1007/s10142-022-00841-z PMC 바로가기 [Article Type] Article

Gene Set Enrichment Analysis Reveals That Fucoidan Induces Type I IFN Pathways in BMDC

유전자 세트 농축 분석을 통해 후코이단이 BMDC에서 I형 IFN 경로를 유도한다는 사실이 밝혀졌습니다

Article

Published on 2022-05-272022-09-11
Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

[키워드] activate Analysis Antigen presentation Antiviral antiviral activity BMDC CD40 CD80 cytometric DEGs dendritic dendritic cell dendritic cells differentially expressed gene Differentially expressed genes differentially expressed genes (DEGs) driven by enrichment enrichment analysis Flow Flow cytometric analysis fucoidan gene set enrichment analysis gene set enrichment analysis (GSEA) greater GSEA highlighting IFN IFN-stimulated gene immune cells Inflammatory response innate immune Innate immune cells IRF ISG ISGs maturation mechanism MHCII NF-κB NLR nucleic acid pathway Pathways polysaccharide potential mechanism Prevent PRR receptor SARS-CoV-2 Signaling STAT STING sulfated surface marker TLR transcription factors transcriptional change transcriptionally Transcriptome transcriptome change treat Type type I Type I IFN type I interferon upregulated viral infections viruses
[DOI] 10.3390/nu14112242 PMC 바로가기 [Article Type] Article

Identification of Diagnostic Gene Markers and Immune Infiltration in Systemic Lupus

전신성 루푸스에서 진단 유전자 마커 및 면역 침윤의 식별

Article

Published on 2022-05-102022-09-11
Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 바이오마커, 치료기술,

[키워드] Activation advancement Analysis analyzed Atypical autoantibodies autoantibody Autoantigens Autoimmune disease B cells bioinformatics Biomarker Central nervous system characteristic clinical manifestation clinical manifestations Clinical practice coexpressed coexpression network complexes control group coronavirus coronavirus disease correlation COVID-19 current DEGs determine Diagnosis diagnostic differentially expressed gene Differentially expressed genes disease downloaded downregulated Endocrine endocrine system enrichment analysis etiology evaluate expression data Factors fraction functional gene expression profile Genes Genetic GEO database healthy control healthy controls help heterogeneous highest hub genes human body identification identify Immune cell immune cells Immune complexes immune function Infection Interaction joints KEGG kidney leukemia Lupus lupus erythematosus miRNA multiple organs Participation Pathogenesis pathway Pathways Patient patients performed Population Potential biomarker potential biomarkers PPI PPI network protein-protein interaction receiver operating characteristic recognize regulatory network Research resulting ribosome ROC ROC Curve RPL19 RPS17 RPS19 RPS7 selected skin SLE SLE patient SLE patients Symptom systemic systemic lupus erythematosus T cell T cells the disease the healthy transcription factor Treatment turquoise module upregulated variety virus was selected was used weighted gene coexpression network analysis WGCNA whole blood sample
[DOI] 10.1155/2022/3386999 PMC 바로가기 [Article Type] Article

Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus

Research

Published on 2022-04-152022-10-05
Journal: Genes and Immunity [Category] 바이오마커,

Bioinformatics and System Biology Approach to Identify the Influences of COVID-19 on Rheumatoid Arthritis

류마티스 관절염에 대한 COVID-19의 영향을 식별하기 위한 생물정보학 및 시스템 생물학 접근

Article

Published on 2022-04-072022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis approach Arthritis association bioinformatics Biology candidate drug condition coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients dataset datasets DEGs differentially expressed differentially expressed gene Differentially expressed genes drug drug molecule functional functional enrichment generate hub genes identify Infection influence interactions mechanism molecular mechanism molecular mechanisms Mortality ontological Pathway analysis performed potential molecular PPI PPI network progression protein-protein interaction proteinprotein interaction rapid increase Rheumatoid rheumatoid arthritis SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease statistical System Systems biology targeted therapy Transcription transcription factor Treatment were used
[DOI] 10.3389/fimmu.2022.860676 PMC 바로가기 [Article Type] Article

Tracing the SARS-CoV-2 infection on the ocular surface: Overview and preliminary corneoscleral transcriptome sequencing

안구 표면의 SARS-CoV-2 감염 추적: 개요 및 예비 각막 공막 전사체 시퀀싱

Article

Published on 2022-04-012022-09-11
Journal: Experimental eye research [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] absence ADAMTS4 Analysis AQP5 associable caused Cluster Clusters component Cornea Corneal Corneoscleral ring COVID-19 CTRL Cytokines DEGs differentially expressed gene Differentially expressed genes Donor down-regulated gene down-regulated genes enrichment analysis Eye bank gene expression profile Gene ontology Genes genomic genomic RNA GO analysis GO term IL6 Illumina inactive indicated infected individual infected individuals Infection interferon interferon pathway ISG ISG15 ISGs Local Manifestations MMP1 modulation molecular mechanism molecular mechanisms ocular Ocular surface pathway PCA PCA analysis performed Perturbation positive Post-mortem principal Principal component principal component analysis proinflammatory cytokines Protective qRT-PCR RNA RNA-sequencing RSAD2 SARS-CoV-2 SARS-CoV-2 RNA several gene several genes Support tears the interferon the SARS-CoV-2 tissue tracing transcriptional Transcriptome transcriptome analysis transcriptome sequencing virus was performed
[DOI] 10.1016/j.exer.2022.108975 PMC 바로가기 [Article Type] Article

Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing

SARS-COV-2 감염 및 약물 용도에 영향을 미치는 기능, 경로 및 조절제를 강조하는 숙주 게놈 바이오 마커의 계산 식별

Article

Published on 2022-03-112022-08-31
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 신약개발, 치료제,

[키워드] 3CL Analysis analyzed binding affinities Biomarker candidate drugs Computational biology and bioinformatics control sample COVID-19 CXCL2 daclatasvir DEGs differentially expressed gene docking drug Drug discovery drug target drugs Economy effective enrichment analysis FDA approved Drugs function functional functions genomic GUCY1A2 highlighting Host hub-genes identify IGF2 independent indicate infections Interaction investigated IRF7 Ivermectin KEGG pathway KLF6 life miRNA miRNAs molecular docking analysis NEDD9 network analysis PAG1 pandemic pathway Pathways performed PPI Protein Protein–protein interaction Proteins Radotinib Rapamycin receptor receptor protein receptor proteins receptors reduced RNA sequence SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Seven signaling pathway signaling pathways significantly SNRPD2 stability Stat1 Systems biology tacrolimus the SARS-CoV-2 Thiostrepton TLR2 transcriptomics Treatment USP53 vaccination variants of SARS-CoV-2 ZFP36
[DOI] 10.1038/s41598-022-08073-8 PMC 바로가기 [Article Type] Article

An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages

조작된 나노 리포솜 인간 ACE2 미끼는 쥐와 인간 대식세포 모두에서 SARS-CoV-2 스파이크 단백질 유도 염증을 중화합니다

Article

Published on 2022-03-062022-09-11
Journal: Theranostics [Category] SARS, 유전자 메커니즘,

[키워드] abrogate abrogated ACE2 activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding biotinylated canonical CCL-2 chemokines competitive inhibitor complex coronavirus CXCL-10 cytokine D614G deficiency DEGs demonstrated differentially expressed gene Effect enzyme expressing expression fusion generate glycoprotein hACE2 human ACE2 human host cells human macrophage human macrophages IKKβ IKKβ/NF-κB signaling IL-1β IL-6 Immune cell immune cells in vitro in vivo Infection Inflammation Inflammatory response Inflammatory responses inhibit SARS-CoV-2 inhibitor internalization Intravenous injection IκB lentivirus Liposome Liposome-Human ACE2 Macrophage macrophages mechanism mice molecular murine myeloid-specific IKKβ knockout. neutralize NF-κB NF-κB activation NF-κB signaling Protein rationale receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 spike glycoprotein severe acute respiratory syndrome Coronavirus Signaling spike spike glycoprotein Spike protein stimulated Therapeutic approach tissue inflammation TNFα Treatment was used wild type
[DOI] 10.7150/thno.66831 PMC 바로가기 [Article Type] Article

Bioinformatics approach to identify common gene signatures of patients with coronavirus 2019 and lung adenocarcinoma

코로나바이러스 2019 및 폐 선암종 환자의 공통 유전자 서명을 식별하기 위한 생물정보학 접근법

Article

Published on 2022-03-012022-09-11
Journal: Environmental science and pollution research inter [Category] MERS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] approach association bioinformatics biological process cells cellular component co-expressed commonality Coronavirus 2019 coronavirus disease Coronavirus disease 2019 correlation COVID-19 database dataset DEGs develop differentially expressed gene Differentially expressed genes Diseases enrichment analysis evaluate expressed Gene Expression Gene regulatory networks gene signature global pandemic Healthcare systems hub gene hub genes identify immune immune infiltration infected with COVID-19 lung adenocarcinoma lung cancer management Methylation molecular organs pathological mechanism Pathways Patient patients with COVID-19 platform PPI protein-protein interaction Regulatory reveal SARS-CoV-2 severe disease significantly Spearman transcription factor treating Treatment was obtained were used with COVID-19
[DOI] 10.1007/s11356-021-17321-9 PMC 바로가기 [Article Type] Article