Manifesto of the pediatricians of Emilia-Romagna region, Italy, in favor of vaccination against COVID in children 5–11 years oldDebate Published on 2022-03-052022-10-29 Journal: Italian Journal of Pediatrics [Category] COVID-19, MERS, SARS, [키워드] activity Adults age Caccine hesitancy caused children conscious contribute COVID COVID-19 COVID-19 vaccines Cultural developmental disease effective Emilia-Romagna family favor Federation form growth Health hospital information Italian Italy Manifesto mental health neonatology Paediatric infectious diseases pandemic parent parents pathology Pediatrician pediatrics PROTECT Region regulatory authority Safe SARS-CoV-2 SARS-COV-2 infection School Side effects Society Spread Stress the vaccine union Vaccinating vaccination Vaccine virus [DOI] 10.1186/s13052-022-01229-2 PMC 바로가기 [Article Type] Debate
Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis폐 섬유증에서 폐포 상피 줄기 세포 노화 및 노화 관련 분화 장애의 분자 기전Review Published on 2022-03-032022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] accelerated alveolar caused Cell cell senescence cellular senescence COVID-19 Degradation developmental differentiation disorder disrupt DNA damage DNA damage response dysfunction epithelial fibrosis followed by framework Idiopathic pulmonary fibrosis induce inhibiting inhibitor Intervention IPF low-grade inflammation mechanism molecular mechanism molecular mechanisms OIS oncogene pathway Premature Protein pulmonary pulmonary fibrosis replicative replicative senescence reported reverse transcriptase RNA SARS-CoV-2 viral infection senescence senescent cell senescent cells STEM stem cell suppression susceptibility telomerase telomerase and telomeres. telomeres TERC TERT TGF TGF-β TGF-β signalling TPP1 transcriptase Viral viral infection [DOI] 10.3390/cells11050877 PMC 바로가기 [Article Type] Review
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M pro inhibitor in animal models동물 모델에서 경구용 SARS-CoV-2 M pro 억제제인 니르마트렐비르(PF-07321332)의 생식 및 발달 안전성Article Published on 2022-03-012022-09-11 Journal: Reproductive toxicology (Elmsford, N.Y.) [Category] 치료제, [키워드] administration age animal model Antiviral Clinical studies clinical study clinically coronavirus COVID-19 Critical death developmental during pregnancy Effect Embryo Embryo-Fetal development embryonic embryonic development enhancer evaluated Factor female female fertility Fertility Genetic Genetic toxicity high risk Hospitalization hospitalized patient ICH in viral infected with SARS-CoV-2 information inhibitor lack limit dose M pro male mammalian cells manifestation Nirmatrelvir NMV no effect no effects oral Oral COVID-19 therapy patient population Paxlovid PF-07321332 pharmacokinetic phase Pregnancy Prevent progression protease Protein rabbit RAT Rat. RATs Replication reported reproductive risk Ritonavir SARS-CoV-2 SARS-CoV-2 main protease selective severe disease shown specific protein the SARS-CoV-2 therapeutic option therapeutic target therapy Toxicity viral replication virus [DOI] 10.1016/j.reprotox.2022.01.006 PMC 바로가기 [Article Type] Article
Drug repurposing for SARS-CoV-2 main protease: Molecular docking and molecular dynamics investigationsResearch article Published on 2022-03-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] Analysis approved approved drug benefit binding free energy ChEMBL collected COVID-19 developmental docked docking docking score drug Drug repurposing Ebola illness less main protease management medication MERS-CoV molecular molecular docking molecular dynamics MPro novel corona virus PDB Precision protease receptor Repurposed drugs Research risk SARS-CoV-2 therapeutic strategy therapeutic targets viral disease Virtual screening virus [DOI] 10.1016/j.bbrep.2022.101225 [Article Type] Research article
Evaluation of Swab-Seq as a scalable, sensitive assay for community surveillance of SARS-CoV-2 infectionArticle Published on 2022-02-232022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] addition asymptomatic individual clinically collected Community developmental diagnostic Effectiveness effort evaluated expand gold standard independent individual Intensive lab less Modification nasal swab nasopharyngeal Next-generation sequencing noninvasive NP swab polymerase chain protocol qRT-PCR qRT-PCR assay Quantitative repeated resource reverse transcription RNA RNA sequencing Saliva SARS-COV-2 infection SARS-CoV-2 pandemic Scientific community stability subsequent Surveillance Swab symptomatic and asymptomatic utility viral infection [DOI] 10.1038/s41598-022-06901-5 PMC 바로가기 [Article Type] Article
Linked nosocomial COVID-19 outbreak in three facilities for people with intellectual and developmental disabilities due to SARS-CoV-2 variant B.1.1.519 with spike mutation T478K in the NetherlandsSARS-COV-2 변형으로 인한 지적 및 발달 장애가있는 사람들을위한 3 개의 시설에서 연결된 병원체 CovID-19 발생 B.1.1.519 네덜란드에 스파이크 돌연변이 T478K가있는Research Published on 2022-02-102022-09-10 Journal: BMC Infectious Diseases [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] Asymptomatic attack attack rate B.1.1.519 variant Characteristics circulating variants clinical clinical information confirmed case COVID-19 infection developmental developmental disabilities died dominant Evidence Genotype Hospitalized increased risk index individual Infection prevention Infection prevention and control information Intellectual and developmental disability intrinsic measure Median viral load morbidity morbidity and mortality Mortality Netherland Netherlands no significant difference nosocomial COVID-19 notification Observed outbreak PCR Prevalence protocol reported Result SARS-CoV-2 SARS-CoV-2 variant Sequencing significant difference specimen spike mutation submitted subsequent supplementary material Support Surveillance T478K T478K spike mutation Travel vaccination against COVID-19 variant Viral [DOI] 10.1186/s12879-022-07121-y PMC 바로가기 [Article Type] Research
Face masks disrupt holistic processing and face perception in school-age childrenOriginal Article Published on 2022-02-072022-10-31 Journal: Cognitive research: principles and implications [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] adjusted Adults age alteration Cambridge children conditions correlation COVID-19 COVID-19 pandemic developmental disrupt Evidence exhibited face Face mask Face perception groups hallmark Holistic processing Human Inclusion Inversion effect mandatory Mask Masked face Masks Quantitative recent reduced Research subject suggested supplementary material Test tested trajectory [DOI] 10.1186/s41235-022-00360-2 PMC 바로가기 [Article Type] Original Article
Sociodemographic and clinical characteristics of paediatric patients admitted to a neuropsychiatric care hospital in the COVID-19 eraObservational Study Published on 2022-02-052022-10-04 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] activity addition adolescents age analysed Care caused change changed Chi square test children Clinical characteristics clinical variables COVID COVID-19 COVID-19 group COVID-19 pandemic decrease developmental disorders Effect Effects epidemiological event Factor greater Health health emergency hospital hospitalisation hospitalised increase in Inpatient Italy mental health Mental health disorder Neuropsychiatric neuropsychiatric disease neuropsychiatry North occurred Paediatric age paediatric patient Patient percentages pharmacological physical Prevalence problem psychiatric disorder recruited Result retrospective cohort Sociodemographic Standard deviation t-test therapy unit [DOI] 10.1186/s13052-022-01213-w PMC 바로가기 [Article Type] Observational Study
Developmental Assets, Self-Control and Internet Gaming Disorder in Adolescence: Testing a Moderated Mediation Model in a Longitudinal StudyPublic Health Published on 2022-02-042022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] Adolescent classification conducted contribute COVID-19 pandemic Critical developmental developmental assets disorder Effect evaluated Gender Internet Internet gaming disorder less longitudinal longitudinal mediation model measure mediation mediation model Model not significant Perspective positive predict Prevent reduce Result self-control Testing turn was determined [DOI] 10.3389/fpubh.2022.808264 PMC 바로가기 [Article Type] Public Health
Integrated Analysis Reveals the Characteristics and Effects of SARS-CoV-2 Maternal–Fetal TransmissionMicrobiology Published on 2022-01-272022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Affect affected Analysis Angiotensin-converting enzyme binding biological processe Care caused cells Characteristics CMV co-expressed conducted coronavirus coronavirus disease COVID-19 developmental Effect embryonic ENhance expressed expression level Factor fetal fetal development Health healthy high risk higher risk Infection Integrated analysis intestine key factor lung maternal–fetal transmission molecular mechanism much higher pandemic pathogen pathway physical barrier Placenta prenatally Prevent Probability provide receptor reported risk SARS-CoV-2 SARS-COV-2 infection sequencing data single-cell Spread stages T-cell activation tissue tissues TMPRSS2 Transcriptome transmembrane serine protease Transmission transmission rate virus infection Zika virus ZIKV [DOI] 10.3389/fmicb.2022.813187 PMC 바로가기 [Article Type] Microbiology