Developing a SARS-CoV-2 main protease binding prediction random forest model for drug repurposing for COVID-19 treatmentarticle Published on 2023-11-242024-09-05 Journal: Experimental Biology and Medicine [Category] update2024, [키워드] binding activity Drug repurposing main protease Predictive model Random forest SARS-CoV-2 [DOI] 10.1177/15353702231209413 PMC 바로가기 [Article Type] article
Antiviral Potential of Azelastine against Major Respiratory VirusesArticle Published on 2023-11-232024-09-05 Journal: Viruses [Category] update2024, [키워드] Antiviral azelastine Drug repurposing respiratory viruses RSV [DOI] 10.3390/v15122300 PMC 바로가기 [Article Type] Article
Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventionsResearch Article Published on 2023-11-192024-09-05 Journal: Virologica Sinica [Category] update2024, [키워드] Drug repurposing Hepatitis E virus (HEV) Pyrazofurin pyrimidine biosynthesis Vidofludimus calcium [DOI] 10.1016/j.virs.2023.11.006 PMC 바로가기 [Article Type] Research Article
The interplay of drug therapeutics and immune responses to SARS-CoV-2Review Article Published on 2023-11-142024-09-05 Journal: Cellular and Molecular Immunology [Category] update2024, [키워드] Adaptive immunity Antimicrobial responses Bisphosphonates Drug repurposing Nirmatrelvir SARS-CoV-2 viral infection [DOI] 10.1038/s41423-023-01098-7 PMC 바로가기 [Article Type] Review Article
RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severityArticle Published on 2023-11-082024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] COVID-19 disease severity Drug repurposing longitudinal profiling Monocytes RAGE SARS-CoV-2 single-cell multi-omics [DOI] 10.1016/j.xcrm.2023.101266 PMC 바로가기 [Article Type] Article
The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label usearticle Published on 2023-10-312024-09-05 Journal: Parasites & Vectors [Category] update2024, [키워드] Acedapsone albendazole amoxicillin Artemether artemisinins Arterolane artesunate Azithromycin azoles Balapiravir celgosivir Chloroquine clarithromycin Clavulanate CURE ID dapsone Diethylcarbamazine disulfiram doxycycline Drug reprofiling Drug repurposing fluconazole Imatinib Isavuconazonium itraconazole Ivermectin ketoconazole Levamisole Lumefantrine Mebendazole mefloquine Moxidectin moxifloxacin Neglected topical diseases nitazoxanide off-label use Oxamniquine Oxantel Piperaquine Posaconazole Praziquantel Pyrantel pamoate ravuconazole ribavirin rifampicin Rifapentine Sparfloxacin streptomycin Tribendimidine UV-4B [DOI] 10.1186/s13071-023-05909-8 PMC 바로가기 [Article Type] article
Repurposing of H 1 -receptor antagonists (levo)cetirizine, (des)loratadine, and fexofenadine as a case study for systematic analysis of trials on clinicaltrials.gov using semi-automated processes with custom-coded softwareResearch Published on 2023-10-232024-09-05 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] update2024, [키워드] Clinical trials as topic Drug repurposing Information storage and retrieval [DOI] 10.1007/s00210-023-02796-9 PMC 바로가기 [Article Type] Research
Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatmentsarticle Published on 2023-10-062024-09-05 Journal: Virology Journal [Category] update2024, [키워드] COVID-19 Drug repurposing Real world data Real world evidence retrospective cohort [DOI] 10.1186/s12985-023-02195-9 PMC 바로가기 [Article Type] article
Community-based management of a five-arm randomised clinical trial in COVID-19 outpatients in South Africa: challenges and opportunitiesarticle Published on 2023-10-042024-09-05 Journal: Trials [Category] update2024, [키워드] Clinical research management Clinical trial design COVID-19 Drug repurposing Outpatient South Africa [DOI] 10.1186/s13063-023-07577-6 PMC 바로가기 [Article Type] article
Developing kinase inhibitors for malaria: an opportunity or liability?article Published on 2023-09-302024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] Drug repurposing kinases malaria Polypharmacology resistance target-based drug discovery [Article Type] article