Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedsideReview Published on 2021-05-282023-07-01 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, [키워드] biochemical analysis Coronaviridae drug targets Multi-target pharmacology pathophysiology therapeutic design [DOI] 10.1016/j.meegid.2021.104944 PMC 바로가기 [Article Type] Review
Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approachesCOVID-19에 대한 잠재적 약물 표적 및 후보 약물 식별: 생물학적 네트워크 및 구조 모델링 접근법Research Article Published on 2021-05-172022-08-31 Journal: F1000Research [Category] MERS, 치료기술, 치료제, [키워드] acute respiratory syndrome addition Algorithm Analysis Antigen antigen processing approach BCL3 binding affinity Biological network analysis Biomarker Biomarkers candidate drug candidate drugs CBL CEBPB complex conducted coronavirus CoV CoV infection COVID-19 CRKL cytokine demonstrated docking result drug target drug targets ERBB4 expressed expression expression profile expression profiles facilitate flexibility growth factor growth factor receptor binding HDAC9 host cell host gene host immune system human pathogen identifying immune signaling pathway include indicated inhibit innate immune response interleukin interleukin-1 KLHL12 Limma macropinocytosis MAPK MAPK signaling medicated MHC class I modulation module molecular dynamics Molecular dynamics simulation molecular dynamics simulations mortality rate MYC NCOA3 network analysis pathway Pathways peptide PPI PPI network protein-protein docking protein-protein interaction receptor Receptor binding receptor signaling reduce regulate Replication respiratory Respiratory system retrieved SARS-CoV-2 SARS-CoV-2 pathogenesis selected Severe acute respiratory syndrome Signal transduction signal transduction pathways Signaling signaling pathways Smad3 SMURF1 stability stimulatory T cell T cell receptor tyrosine VEGFA Walktrap algorithm was selected wortmannin [DOI] 10.12688/f1000research.50850.3 PMC 바로가기 [Article Type] Research Article
Predicting COVID-19—Comorbidity Pathway Crosstalk-Based Targets and Drugs: Towards Personalized COVID-19 ManagementArticle Published on 2021-05-172022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] adopted Analysis applied approved drug bioinformatics cancers cardiovascular disease Chronic kidney disease chronic obstructive Combination comorbid condition Comorbidity component COPD COVID-19 COVID-19 case COVID-19 patients data set death diabetes drug drug targets fatality gold standard hypertension implementation Interaction lack literature management molecular obesity pathogenesis of COVID-19 pathway personalized therapy predicted provided pulmonary disease severity shared pathway shared pathways Support target therapeutic Treatment [DOI] 10.3390/biomedicines9050556 PMC 바로가기 [Article Type] Article
Virus-Host Cell Interplay during Hepatitis E Virus InfectionReview Published on 2021-04-012023-06-11 Journal: Trends in microbiology [Category] E형 간염, Fulltext, [키워드] drug targets hepatitis E virus HEV life cycle Host factor host interaction. [DOI] 10.1016/j.tim.2020.07.002 PMC 바로가기 [Article Type] Review
Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious DiseasesReview Published on 2021-03-162024-09-02 Journal: Frontiers in Genetics [Category] 대상포진, [키워드] aquaporins and infectious diseases drug targets functional regulation human aquaporins water homeostasis [DOI] 10.3389/fgene.2021.654865 PMC 바로가기 [Article Type] Review
Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis소외된 열대 질병인 아메바증에 대한 약물 개발 재조명Article Published on 2021-02-242024-07-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] 세균성이질, [키워드] Amebiasis drug repurposing and discovery drug targets metabolic enzymes metabolic kinases Proteases protein kinases protozoan parasite [DOI] 10.3389/fcimb.2020.628257 PMC 바로가기
Potential drug targets of SARS-CoV-2: From genomics to therapeuticsReview Published on 2021-02-092023-07-02 Journal: International journal of biological macromolecules [Category] SARS, [키워드] coronavirus disease 19 drug targets severe acute respiratory syndrome coronavirus-2 [DOI] 10.1016/j.ijbiomac.2021.02.071 PMC 바로가기 [Article Type] Review
Drug repurposing approach to combating coronavirus: Potential drugs and drug targetsReview Published on 2021-01-312023-06-14 Journal: Medicinal research reviews [Category] MERS, SARS, [키워드] anti-CoV coronavirus COVID-19 Drug repurposing drug targets MERS-CoV SARS-CoV SARS-CoV-2 small molecule drugs [DOI] 10.1002/med.21763 PMC 바로가기 [Article Type] Review
A Comparative Review on Current and Future Drug Targets Against Bacteria & Malariaarticle Published on 2020-12-312024-09-01 Journal: Current Drug Targets [Category] 말라리아, [키워드] drug resistance drug targets Infectious diseases malaria MDR Pseudomonas aeruginosa [Article Type] article
System biological investigations of hydroxychloroquine and azithromycin targets and their implications in QT interval prolongationArticle Published on 2020-12-012022-10-04 Journal: Chemico-biological interactions [Category] SARS, 신약개발, [키워드] absence administration Adverse adverse event Adverse reactions affecting AKT1 Algorithm Azithromycin cardiac Cardiac arrhythmia Combination Complete Consensus correlation Coverage COVID-19 COVID-2019 database drug drug combination drug target drug targets effective ERBB2 Final HCQ HSP90AA1 hub protein Hydroxychloroquine implication Interaction involved limitation network network pharmacology node degree pandemic pathway patients performed Protein QT interval reached reduce risk screened subsequent System target therapeutic option Treatment VEGF [DOI] 10.1016/j.cbi.2020.109299 PMC 바로가기 [Article Type] Article