effector – Page 3 – Communicable Diseases Research

The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells

Microbiology

Published on 2021-10-282022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL pro substrate degradome

SARS-CoV-2 3CL pro 기질 분해에 대한 글로벌 분석을 통한 COVID-19에 대한 기계론적 통찰력

Article

Published on 2021-10-262022-09-12
Journal: Cell Reports [Category] MERS, SARS, 진단, 치료제,

[키워드] 3CL pro accelerate active site structure amplify Analysis bind binding Cell cleavage cleavage sites consequence COVID-19 degradomics drug design effector effector proteins global analysis glycoprotein healthy human lung identify inactivation interactome kidney lung Lungs MAP4K5 molecular docking mRNA pathology pathway Post-mortem protease Proteases Protein proteomics SARS-CoV SARS-CoV-2 SARS-CoV-2 3CL(pro) SARS-CoV-2 main protease SARS-CoV-2 replication SARS-CoV-2-infected cells specificity spike subsite specificity substrate substrates substrates. supported target the SARS-CoV-2 Transcription translation
[DOI] 10.1016/j.celrep.2021.109892 PMC 바로가기 [Article Type] Article

The Application of CRISPR/Cas Systems for Antiviral Therapy

Genome Editing

Published on 2021-10-132022-10-31
Journal: Frontiers in Genome Editing [Category] COVID-19,

[키워드] acute infection Antiviral antiviral therapies application Cas13 Cas9 cleave CRISPR DNA and RNA effector effort Hepatitis hepatitis B highlight HIV Human infecting infections Pathogens Perspective problems RNA virus SARS-CoV-2 System variety viral genomes virus viruses
[DOI] 10.3389/fgeed.2021.745559 PMC 바로가기 [Article Type] Genome Editing

Role of Extracellular Vesicles in Cell Death and Inflammation

세포 사멸 및 염증에서 세포외 소포의 역할

Review

Published on 2021-10-052022-09-11
Journal: Cells [Category] MERS, SARS, 바이오마커, 진단,

Monocyte Chemotactic Protein-Induced Protein 1 (MCPIP-1): A Key Player of Host Defense and Immune Regulation

Immunology

Published on 2021-10-012022-11-01
Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS,

[키워드] Acute inflammation biological function blunt cardiovascular diseases cardiovascular system Cell clearance conserved COVID-19 dead cells Diseases effector Evidence expression Factor healthy highlight homeostasis Host immune function immunopathology Infection infections Infectious disease Inflammation Inflammatory Inflammatory diseases Inflammatory mediators Inflammatory response ischemic inflammation knock-out MCPIP-1 mechanism microbial microRNA miRNA monocyte mouse model mRNA neurodegenerative NFκB outlined Pleiotropic effects Protein public health recent Regulation Resolution signaling pathways stability syndrome target Therapeutic treatment tissue damage tissue injury tissue regeneration tissues transgenic viral infection virus
[DOI] 10.3389/fimmu.2021.727861 PMC 바로가기 [Article Type] Immunology

The ROMANOV study found impaired humoral and cellular immune responses to SARS-CoV-2 mRNA vaccine in virus-unexposed patients receiving maintenance hemodialysis

ROMANOV 연구는 유지 혈액투석을 받고 있는 바이러스에 노출되지 않은 환자에서 SARS-CoV-2 mRNA 백신에 대한 손상된 체액 및 세포 면역 반응을 발견했습니다

Article

Published on 2021-10-012022-09-12
Journal: Kidney international [Category] MERS, SARS, 진단,

[키워드] absence Analysis Anti-RBD IgG Anti-spike benefit BNT162b2 CD4 CD8 Cell Cellular immune response circulation Complete correlated COVID-19 COVID-19 in patient death dose effector generate healthy volunteer healthy volunteers Hemodialysis high risk humoral IgG immune immune response immune responses immunosuppressive Infection injection interferon less mRNA vaccine mRNA vaccines naïve of BNT162b2 Patient RBD receiving Receptor binding domain SARS-CoV-2 SARS-CoV-2 virus significantly T cell T cells therapy vaccination Vaccine vaccine injection virus weakened were excluded were measured
[DOI] 10.1016/j.kint.2021.07.005 PMC 바로가기 [Article Type] Article

Sphingolipids: Effectors and Achilles Heals in Viral Infections?

Review

Published on 2021-08-242022-10-31
Journal: Cells [Category] Coronavirus, SARS,

Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model

비강 내 I형 인터페론 치료는 SARS-CoV-2 햄스터 모델에서 임상 징후가 발병하기 전에 투여할 때만 유익합니다.

Research Article

Published on 2021-08-092022-09-10
Journal: PLoS Pathogens [Category] SARS, 치료제,

[키워드] Administered administration Antiviral caused Clinical course Clinical sign clinical trial clinical trials COVID-19 patients days post-infection Deleterious deleterious effects demonstrated disease Effect effector Efficacy and safety Evidence had no Host IFN-α IFNs immunopathology Impaired Infection information interferon interferons Intervention intranasal lung titers MERS MERS-CoV mice modulate observation onset of symptom onset of symptoms patients Post-infection preclinical study produced provide provided SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe COVID-19 shown Signaling Stage the SARS-CoV-2 the timing Therapeutics Treatment Type Type I IFN type I IFNs type I interferon type I interferons Viral viral infections weight loss
[DOI] 10.1371/journal.ppat.1009427 PMC 바로가기 [Article Type] Research Article

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Article

Published on 2021-07-132022-10-04
Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제,

[키워드] antiviral drug antiviral therapeutics approach B.1.1.7 cellular circumvent CRISPR CRISPR-Cas systems D614G degrade demonstrated described dominant variant effector Efficiency genomic highlight host immunity impair Interaction mammalian cell mammalian cells molecular Mutagenesis mutant mutated pathogenic viruses Prevent Region replication-competent SARS-CoV-2 Resilience RNA RNA transcript RNAi RNAi therapy SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 replication SARS-CoV-2 strain SARSCoV-2 single-nucleotide specificity spike subgenomic RNAs suppress suppresse Synthetic biology the Spike Tolerance transcript variant variants of concern viral escape viral replication
[DOI] 10.1038/s41467-021-24577-9 PMC 바로가기 [Article Type] Article

A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients

림프구 적응 면역 레퍼토리 및 전사체의 단일 세포 아틀라스는 회복기 COVID-19 환자의 연령 관련 차이를 보여줍니다

Comparative Study

Published on 2021-07-122022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘,

[키워드] Activation adaptive Adaptive immune response Adaptive immunity age Analysis antibody Atla B cell B cell receptor B cell receptors B cells B lymphocytes BCR CD4 CD8 Cell cell receptor clearance clone convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 COVID-19 disease COVID-19 patient Critical cytotoxicity dependent on difference effector elderly patients elevated GNLY groups GzmA GZMH IgA immune Immunity implicated knowledge lymphocyte Lymphocytes marker outcome Patient patients plasma Plasma cell PRF1 receptor repertoire SARS-CoV-2 Sequencing single-cell T and B cells T and B lymphocytes T cell TCRs Transcriptome transcriptomes transition VDJ repertoire
[DOI] 10.3389/fimmu.2021.701085 PMC 바로가기 [Article Type] Comparative Study